GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | I | 390 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | TM5 | F | 267 | 5x73 | G.H4 | L | 313 | G.H4.12 |
Van-der-waals | TM5 | F | 267 | 5x73 | G.H4 | L | 313 | G.H4.12 |
Hydrophobic | ICL2 | L | 170 | - | G.H5 | V | 363 | G.H5.15 |
Polar | TM6 | R | 275 | 6x26 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | TM6 | R | 275 | 6x26 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | TM5 | P | 265 | 5x71 | G.S6 | F | 340 | G.S6.02 |
Polar | C-term | D | 388 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | TM6 | R | 275 | 6x26 | G.H5 | L | 374 | G.H5.26 |
Polar | C-term | C | 389 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | C | 389 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | C | 389 | - | G.S2 | C | 196 | G.S2.05 |
Polar | TM2 | N | 95 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM2 | N | 95 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | TM2 | N | 95 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Polar | TM6 | C | 278 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | C | 278 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | C | 278 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Polar | C-term | I | 390 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | I | 390 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | I | 390 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | TM5 | K | 262 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | L | 259 | 5x65 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM5 | P | 265 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | TM5 | P | 265 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | ICL2 | P | 172 | - | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | TM6 | R | 279 | 6x30 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | C-term | L | 392 | - | G.S2 | F | 197 | G.S2.06 |
Van-der-waals | C-term | L | 392 | - | G.S2 | F | 197 | G.S2.06 |
Hydrophobic | TM2 | T | 97 | 2x39 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | C-term | I | 390 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | TM5 | V | 264 | 5x70 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | C-term | V | 387 | - | G.S3 | R | 205 | G.S3.04 |
Hydrophobic | ICL2 | L | 170 | - | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | L | 170 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | L | 259 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Polar | C-term | D | 388 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | D | 388 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | ICL2 | L | 170 | - | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | L | 170 | - | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | ICL2 | L | 170 | - | G.H5 | V | 359 | G.H5.11 |
Hydrophobic | ICL2 | L | 170 | - | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | L | 170 | - | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | C-term | E | 385 | - | G.S2 | I | 192 | G.S2.01 |
Van-der-waals | C-term | E | 385 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | TM6 | R | 279 | 6x30 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM6 | R | 279 | 6x30 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | F | 267 | 5x73 | G.S6 | S | 341 | G.S6.03 |
Polar | TM6 | C | 278 | 6x29 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | C | 278 | 6x29 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | C | 278 | 6x29 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM3 | R | 162 | 3x50 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL4 | K | 346 | - | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | L | 392 | - | G.S2 | S | 198 | G.S2.07 |
Van-der-waals | C-term | L | 392 | - | G.S2 | S | 198 | G.S2.07 |
Hydrophobic | C-term | V | 387 | - | G.S2 | C | 196 | G.S2.05 |
Ionic | TM5 | E | 258 | 5x64 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | P | 265 | 5x71 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | P | 265 | 5x71 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | C-term | L | 392 | - | G.h1ha | G | 67 | G.h1ha.01 |
Van-der-waals | C-term | L | 392 | - | G.h1ha | G | 67 | G.h1ha.01 |
Hydrophobic | TM3 | I | 166 | 3x54 | G.H5 | Y | 367 | G.H5.19 |
Polar | ICL2 | L | 170 | - | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | ICL2 | L | 170 | - | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM6 | T | 282 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | C-term | A | 383 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | ICL4 | K | 346 | - | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM6 | R | 275 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | R | 275 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | ICL2 | R | 173 | - | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | R | 173 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | L | 392 | - | G.H1 | H | 66 | G.H1.12 |
Van-der-waals | C-term | L | 392 | - | G.H1 | H | 66 | G.H1.12 |
Hydrophobic | TM3 | I | 166 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | ICL2 | P | 169 | - | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | P | 169 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM4 | K | 175 | 4x38 | G.HN | K | 37 | G.HN.52 |
Van-der-waals | TM4 | K | 175 | 4x38 | G.HN | K | 37 | G.HN.52 |
Hydrophobic | ICL2 | P | 169 | - | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | P | 169 | - | G.H5 | V | 363 | G.H5.15 |
Polar | ICL4 | K | 346 | - | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | ICL4 | K | 346 | - | G.H5 | E | 370 | G.H5.22 |
Polar | TM6 | R | 275 | 6x26 | G.h4s6 | R | 337 | G.h4s6.19 |
Van-der-waals | TM6 | R | 275 | 6x26 | G.h4s6 | R | 337 | G.h4s6.19 |
Hydrophobic | ICL2 | P | 172 | - | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | P | 172 | - | G.hns1 | R | 40 | G.hns1.02 |
Polar | C-term | I | 390 | - | G.S2 | F | 197 | G.S2.06 |
Hydrophobic | TM6 | V | 285 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Polar | TM3 | D | 161 | 3x49 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | D | 161 | 3x49 | G.H5 | Y | 367 | G.H5.19 |
Polar | TM6 | R | 275 | 6x26 | G.h4s6 | S | 336 | G.h4s6.18 |
Hydrophobic | C-term | V | 387 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | V | 387 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | ICL2 | P | 169 | - | G.H5 | L | 364 | G.H5.16 |
Polar | TM3 | R | 162 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | R | 162 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | R | 162 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Ionic | ICL2 | R | 173 | - | G.H5 | E | 370 | G.H5.22 |
Polar | ICL2 | R | 173 | - | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | ICL2 | R | 173 | - | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | ICL2 | R | 173 | - | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM3 | I | 166 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM3 | A | 165 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | A | 165 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Polar | TM6 | T | 282 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | T | 282 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | T | 282 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Polar | TM2 | T | 97 | 2x39 | G.H5 | Y | 367 | G.H5.19 |
Polar | H8 | D | 348 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | D | 348 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | D | 348 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | L | 392 | - | G.S2 | V | 199 | G.S2.08 |