GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | P | 265 | 5x71 | G.H5 | F | 330 | G.H5.06 |
Ionic | TM6 | R | 279 | 6x30 | G.H5 | D | 337 | G.H5.13 |
Polar | TM6 | R | 279 | 6x30 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | TM6 | R | 279 | 6x30 | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | TM6 | R | 279 | 6x30 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | C-term | L | 392 | - | G.H3 | S | 248 | G.H3.11 |
Van-der-waals | C-term | L | 392 | - | G.H3 | S | 248 | G.H3.11 |
Aromatic | TM5 | F | 267 | 5x73 | G.H4 | K | 300 | G.H4.12 |
Hydrophobic | TM5 | F | 267 | 5x73 | G.H4 | K | 300 | G.H4.12 |
Van-der-waals | TM5 | F | 267 | 5x73 | G.H4 | K | 300 | G.H4.12 |
Polar | TM6 | T | 282 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM6 | T | 282 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM6 | T | 282 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM5 | L | 259 | 5x65 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | C-term | I | 390 | - | G.H3 | H | 252 | G.H3.15 |
Van-der-waals | C-term | I | 390 | - | G.H3 | H | 252 | G.H3.15 |
Polar | TM6 | Q | 271 | 6x22 | G.h4s6 | K | 313 | G.h4s6.11 |
Hydrophobic | TM6 | Q | 271 | 6x22 | G.h4s6 | K | 313 | G.h4s6.11 |
Van-der-waals | TM6 | Q | 271 | 6x22 | G.h4s6 | K | 313 | G.h4s6.11 |
Polar | TM3 | A | 165 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM3 | A | 165 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | TM3 | A | 165 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Ionic | ICL2 | R | 173 | - | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | ICL2 | R | 173 | - | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | ICL2 | R | 173 | - | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | ICL4 | K | 346 | - | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | ICL4 | K | 346 | - | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | TM5 | P | 265 | 5x71 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | TM5 | P | 265 | 5x71 | G.S6 | Y | 316 | G.S6.02 |
Polar | TM5 | F | 267 | 5x73 | G.S6 | S | 317 | G.S6.03 |
Hydrophobic | TM5 | F | 267 | 5x73 | G.S6 | S | 317 | G.S6.03 |
Van-der-waals | TM5 | F | 267 | 5x73 | G.S6 | S | 317 | G.S6.03 |
Hydrophobic | ICL2 | P | 172 | - | G.hns1 | R | 28 | G.hns1.03 |
Polar | TM2 | T | 97 | 2x39 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM2 | T | 97 | 2x39 | G.H5 | C | 347 | G.H5.23 |
Polar | TM6 | R | 275 | 6x26 | G.S6 | Y | 316 | G.S6.02 |
Hydrophobic | TM6 | R | 275 | 6x26 | G.S6 | Y | 316 | G.S6.02 |
Van-der-waals | TM6 | R | 275 | 6x26 | G.S6 | Y | 316 | G.S6.02 |
Hydrophobic | TM3 | A | 165 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | A | 165 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Polar | TM6 | Q | 271 | 6x22 | G.S6 | I | 315 | G.S6.01 |
Polar | TM2 | N | 95 | 2x37 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM6 | L | 286 | 6x37 | G.H5 | L | 349 | G.H5.25 |
Polar | TM3 | D | 161 | 3x49 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | D | 161 | 3x49 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM5 | F | 267 | 5x73 | G.S6 | H | 318 | G.S6.04 |
Hydrophobic | ICL2 | L | 170 | - | G.H5 | F | 332 | G.H5.08 |
Van-der-waals | ICL2 | L | 170 | - | G.H5 | F | 332 | G.H5.08 |
Hydrophobic | ICL2 | L | 170 | - | G.H5 | T | 336 | G.H5.12 |
Ionic | ICL2 | R | 171 | - | G.s2s3 | D | 189 | G.s2s3.02 |
Hydrophobic | ICL2 | P | 169 | - | G.H5 | T | 336 | G.H5.12 |
Hydrophobic | TM6 | Q | 271 | 6x22 | G.h4s6 | E | 314 | G.h4s6.12 |
Van-der-waals | TM6 | Q | 271 | 6x22 | G.h4s6 | E | 314 | G.h4s6.12 |
Polar | TM4 | Q | 177 | 4x40 | G.HN | K | 20 | G.HN.48 |
Hydrophobic | TM4 | Q | 177 | 4x40 | G.HN | K | 20 | G.HN.48 |
Van-der-waals | TM4 | Q | 177 | 4x40 | G.HN | K | 20 | G.HN.48 |
Hydrophobic | TM6 | R | 279 | 6x30 | G.H5 | I | 340 | G.H5.16 |
Van-der-waals | TM6 | R | 279 | 6x30 | G.H5 | I | 340 | G.H5.16 |
Polar | TM3 | R | 162 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | R | 162 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Polar | ICL2 | R | 173 | - | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL2 | R | 173 | - | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | ICL2 | R | 173 | - | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | R | 162 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM3 | R | 162 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | ICL2 | P | 169 | - | G.H5 | I | 339 | G.H5.15 |
Van-der-waals | ICL2 | P | 169 | - | G.H5 | I | 339 | G.H5.15 |
Polar | ICL2 | P | 169 | - | G.H5 | N | 343 | G.H5.19 |
Polar | TM4 | K | 175 | 4x38 | G.HN | K | 20 | G.HN.48 |
Hydrophobic | TM4 | K | 175 | 4x38 | G.HN | K | 20 | G.HN.48 |
Van-der-waals | TM4 | K | 175 | 4x38 | G.HN | K | 20 | G.HN.48 |
Hydrophobic | TM5 | L | 259 | 5x65 | G.H5 | I | 340 | G.H5.16 |
Ionic | TM4 | K | 175 | 4x38 | G.HN | E | 24 | G.HN.52 |
Polar | TM4 | K | 175 | 4x38 | G.HN | E | 24 | G.HN.52 |
Hydrophobic | TM4 | K | 175 | 4x38 | G.HN | E | 24 | G.HN.52 |
Van-der-waals | TM4 | K | 175 | 4x38 | G.HN | E | 24 | G.HN.52 |
Hydrophobic | TM5 | P | 265 | 5x71 | G.H5 | A | 334 | G.H5.10 |
Van-der-waals | TM5 | P | 265 | 5x71 | G.H5 | A | 334 | G.H5.10 |
Hydrophobic | TM5 | P | 265 | 5x71 | G.H5 | D | 333 | G.H5.09 |
Hydrophobic | TM5 | E | 258 | 5x64 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | C-term | L | 392 | - | G.H3 | L | 245 | G.H3.08 |
Hydrophobic | TM3 | I | 166 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM3 | I | 166 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | ICL2 | L | 170 | - | G.S3 | L | 190 | G.S3.01 |
Hydrophobic | TM5 | V | 264 | 5x70 | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | TM5 | V | 264 | 5x70 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | TM3 | I | 166 | 3x54 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM5 | F | 267 | 5x73 | G.S6 | M | 319 | G.S6.05 |
Van-der-waals | TM5 | F | 267 | 5x73 | G.S6 | M | 319 | G.S6.05 |
Ionic | TM6 | R | 275 | 6x26 | G.H5 | D | 337 | G.H5.13 |
Polar | TM6 | R | 275 | 6x26 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | TM6 | R | 275 | 6x26 | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | TM6 | R | 275 | 6x26 | G.H5 | D | 337 | G.H5.13 |
Polar | TM6 | Q | 271 | 6x22 | G.h4s6 | R | 310 | G.h4s6.08 |
Hydrophobic | TM6 | Q | 271 | 6x22 | G.h4s6 | R | 310 | G.h4s6.08 |
Van-der-waals | TM6 | Q | 271 | 6x22 | G.h4s6 | R | 310 | G.h4s6.08 |
Van-der-waals | C-term | K | 393 | - | G.H2 | R | 201 | G.H2.01 |
Hydrophobic | TM6 | R | 275 | 6x26 | G.H5 | K | 341 | G.H5.17 |
Van-der-waals | TM6 | R | 275 | 6x26 | G.H5 | K | 341 | G.H5.17 |
Polar | ICL2 | R | 173 | - | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | ICL2 | R | 173 | - | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | R | 173 | - | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM5 | G | 266 | 5x72 | G.S6 | S | 317 | G.S6.03 |
Van-der-waals | TM5 | G | 266 | 5x72 | G.S6 | S | 317 | G.S6.03 |
Ionic | TM6 | R | 275 | 6x26 | G.h4s6 | E | 314 | G.h4s6.12 |
Polar | TM6 | R | 275 | 6x26 | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | TM6 | R | 275 | 6x26 | G.h4s6 | E | 314 | G.h4s6.12 |
Van-der-waals | TM6 | R | 275 | 6x26 | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | ICL3 | T | 269 | - | G.H4 | L | 304 | G.H4.16 |
Van-der-waals | ICL3 | T | 269 | - | G.H4 | L | 304 | G.H4.16 |
Hydrophobic | C-term | L | 392 | - | G.H2 | R | 204 | G.H2.04 |
Hydrophobic | ICL2 | P | 169 | - | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | TM5 | G | 266 | 5x72 | G.H5 | F | 330 | G.H5.06 |
Van-der-waals | TM5 | G | 266 | 5x72 | G.H5 | F | 330 | G.H5.06 |
Polar | TM2 | T | 97 | 2x39 | G.H5 | D | 346 | G.H5.22 |
Polar | ICL4 | K | 346 | - | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | ICL4 | K | 346 | - | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | ICL4 | K | 346 | - | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM5 | V | 264 | 5x70 | G.S6 | Y | 316 | G.S6.02 |
Hydrophobic | ICL2 | P | 172 | - | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | ICL2 | L | 170 | - | G.H5 | I | 339 | G.H5.15 |
Van-der-waals | ICL2 | L | 170 | - | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | ICL2 | P | 172 | - | G.HN | E | 24 | G.HN.52 |
Hydrophobic | TM6 | T | 282 | 6x33 | G.H5 | L | 344 | G.H5.20 |