G12 - PrRP receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 R 272 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 272 6x29 G.H5 Q 372 G.H5.17
Ionic ICL2 R 170 - G.H5 D 377 G.H5.22
Polar ICL2 R 170 - G.H5 D 377 G.H5.22
Hydrophobic ECL2 E 213 45x52 G.HN S 2 G.HN.02
Van-der-waals ECL2 E 213 45x52 G.HN S 2 G.HN.02
Hydrophobic ICL2 L 167 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM5 P 258 5x71 G.H5 H 364 G.H5.09
Polar H8 D 340 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 D 340 8x48 G.H5 L 380 G.H5.25
Hydrophobic TM6 T 276 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM3 L 163 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 L 163 3x54 G.H5 L 375 G.H5.20
Polar TM2 A 121 2x64 G.HN R 6 G.HN.06
Hydrophobic TM2 A 121 2x64 G.HN R 6 G.HN.06
Van-der-waals TM2 A 121 2x64 G.HN R 6 G.HN.06
Polar TM2 Y 120 2x63 G.HN V 5 G.HN.05
Hydrophobic TM2 Y 120 2x63 G.HN V 5 G.HN.05
Van-der-waals TM2 Y 120 2x63 G.HN V 5 G.HN.05
Hydrophobic TM5 P 258 5x71 G.H5 D 368 G.H5.13
Polar TM6 R 272 6x29 G.H5 L 375 G.H5.20
Hydrophobic TM6 R 272 6x29 G.H5 L 375 G.H5.20
Van-der-waals TM6 R 272 6x29 G.H5 L 375 G.H5.20
Hydrophobic TM7 H 321 7x38 G.HN V 4 G.HN.04
Polar ECL1 V 128 23x51 G.HN S 9 G.HN.09
Hydrophobic ECL1 V 128 23x51 G.HN S 9 G.HN.09
Van-der-waals ECL1 V 128 23x51 G.HN S 9 G.HN.09
Hydrophobic TM3 R 159 3x50 G.H5 M 379 G.H5.24
Polar TM3 R 159 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 159 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 159 3x50 G.H5 I 378 G.H5.23
Hydrophobic C-term I 370 - G.H2 F 239 G.H2.08
Polar ECL1 G 126 23x49 G.HN S 9 G.HN.09
Van-der-waals ECL1 G 126 23x49 G.HN S 9 G.HN.09
Polar ICL1 H 92 12x51 G.HN R 52 G.HN.52
Hydrophobic ICL1 H 92 12x51 G.HN R 52 G.HN.52
Van-der-waals ICL1 H 92 12x51 G.HN R 52 G.HN.52
Hydrophobic ECL1 F 129 23x52 G.HN L 8 G.HN.08
Van-der-waals ECL1 F 129 23x52 G.HN L 8 G.HN.08
Hydrophobic TM5 P 258 5x71 G.H5 F 361 G.H5.06
Van-der-waals TM5 P 258 5x71 G.H5 F 361 G.H5.06
Hydrophobic ECL2 L 210 - G.HN T 7 G.HN.07
Polar ECL1 W 127 23x50 G.HN T 7 G.HN.07
Van-der-waals ECL1 W 127 23x50 G.HN T 7 G.HN.07
Hydrophobic TM3 F 138 3x29 G.HN G 3 G.HN.03
Van-der-waals TM3 F 138 3x29 G.HN G 3 G.HN.03
Hydrophobic TM6 L 280 6x37 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 280 6x37 G.H5 M 379 G.H5.24
Polar TM6 Q 265 6x22 G.h4s6 R 342 G.h4s6.11
Polar TM6 R 301 6x58 G.HN S 2 G.HN.02
Hydrophobic TM6 R 301 6x58 G.HN S 2 G.HN.02
Van-der-waals TM6 R 301 6x58 G.HN S 2 G.HN.02
Polar ECL1 F 129 23x52 G.HN S 9 G.HN.09
Hydrophobic ECL1 F 129 23x52 G.HN S 9 G.HN.09
Van-der-waals ECL1 F 129 23x52 G.HN S 9 G.HN.09
Hydrophobic TM3 V 162 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 162 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 166 34x50 G.H5 L 371 G.H5.16
Polar TM2 E 123 2x66 G.HN S 9 G.HN.09
Polar H8 H 339 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 H 339 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 H 339 8x47 G.H5 M 379 G.H5.24
Hydrophobic ICL1 L 91 12x50 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 167 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 167 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM5 G 259 5x72 G.H5 F 361 G.H5.06
Polar TM2 Y 120 2x63 G.HN T 7 G.HN.07
Hydrophobic TM2 Y 120 2x63 G.HN T 7 G.HN.07
Van-der-waals TM2 Y 120 2x63 G.HN T 7 G.HN.07
Polar ICL1 R 90 12x49 G.HN R 52 G.HN.52
Polar ICL2 P 166 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 166 34x50 G.H5 N 374 G.H5.19
Polar TM3 Y 146 3x37 G.HN M 1 G.HN.01
Hydrophobic TM3 Y 146 3x37 G.HN M 1 G.HN.01
Van-der-waals TM3 Y 146 3x37 G.HN M 1 G.HN.01
Hydrophobic TM3 L 163 3x54 G.H5 N 374 G.H5.19
Polar TM6 Q 265 6x22 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM6 Q 265 6x22 G.h4s6 K 344 G.h4s6.19
Polar TM2 E 123 2x66 G.HN T 7 G.HN.07
Hydrophobic TM2 E 123 2x66 G.HN T 7 G.HN.07
Van-der-waals TM2 E 123 2x66 G.HN T 7 G.HN.07
Polar TM6 D 269 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 D 269 6x26 G.H5 Q 372 G.H5.17
Ionic ICL1 R 89 12x48 G.HN D 42 G.HN.42
Polar ICL1 R 89 12x48 G.HN D 42 G.HN.42
Van-der-waals ICL1 R 89 12x48 G.HN D 42 G.HN.42
Polar H8 H 339 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 H 339 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 H 339 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM2 N 93 2x37 G.HN R 52 G.HN.52
Van-der-waals TM2 N 93 2x37 G.HN R 52 G.HN.52
Hydrophobic TM7 Q 317 7x34 G.HN V 5 G.HN.05
Van-der-waals TM7 Q 317 7x34 G.HN V 5 G.HN.05
Polar H8 S 341 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 S 341 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM2 A 119 2x62 G.HN L 8 G.HN.08
Van-der-waals TM2 A 119 2x62 G.HN L 8 G.HN.08
Polar TM3 V 162 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 V 162 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 V 162 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL1 R 89 12x48 G.HN A 45 G.HN.45
Hydrophobic TM7 L 318 7x35 G.HN V 5 G.HN.05
Hydrophobic TM6 Q 265 6x22 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 Q 265 6x22 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 R 255 5x68 G.H5 L 375 G.H5.20
Van-der-waals TM5 R 255 5x68 G.H5 L 375 G.H5.20
Hydrophobic TM2 Y 120 2x63 G.HN V 4 G.HN.04
Van-der-waals TM2 Y 120 2x63 G.HN V 4 G.HN.04
Hydrophobic ICL2 L 167 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 167 34x51 G.S3 I 221 G.S3.01
Hydrophobic N-term L 53 - G.HN R 6 G.HN.06
Polar TM6 T 276 6x33 G.H5 Q 381 G.H5.26
Van-der-waals TM6 T 276 6x33 G.H5 Q 381 G.H5.26
Hydrophobic TM5 G 259 5x72 G.S6 H 348 G.S6.03
Van-der-waals TM5 G 259 5x72 G.S6 H 348 G.S6.03
Polar TM6 R 272 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 R 272 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 272 6x29 G.H5 Q 381 G.H5.26
Polar ICL2 R 169 34x53 G.HN A 53 G.HN.53
Hydrophobic ICL2 R 169 34x53 G.HN A 53 G.HN.53
Polar ECL1 G 126 23x49 G.HN T 7 G.HN.07
Hydrophobic ECL1 G 126 23x49 G.HN T 7 G.HN.07
Van-der-waals ECL1 G 126 23x49 G.HN T 7 G.HN.07
Polar TM2 Y 120 2x63 G.HN L 8 G.HN.08
Hydrophobic TM2 Y 120 2x63 G.HN L 8 G.HN.08
Van-der-waals TM2 Y 120 2x63 G.HN L 8 G.HN.08
Hydrophobic TM2 F 122 2x65 G.HN L 8 G.HN.08
Polar TM7 Q 317 7x34 G.HN G 3 G.HN.03
Polar TM2 P 124 2x67 G.HN R 6 G.HN.06
Van-der-waals TM2 P 124 2x67 G.HN R 6 G.HN.06
Hydrophobic TM5 V 257 5x70 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 P 258 5x71 G.S6 F 347 G.S6.02
Van-der-waals TM5 P 258 5x71 G.S6 F 347 G.S6.02
Hydrophobic TM2 T 95 2x39 G.H5 I 378 G.H5.23
Van-der-waals ICL2 R 170 - G.hns1 R 55 G.hns1.02
Polar TM5 C 260 5x73 G.S6 H 348 G.S6.03
Hydrophobic TM5 C 260 5x73 G.S6 H 348 G.S6.03
Van-der-waals TM5 C 260 5x73 G.S6 H 348 G.S6.03
Polar ECL1 W 127 23x50 G.HN S 9 G.HN.09
Van-der-waals ECL1 W 127 23x50 G.HN S 9 G.HN.09
Hydrophobic ICL2 R 169 34x53 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 L 252 5x65 G.H5 L 371 G.H5.16
Hydrophobic TM5 V 257 5x70 G.S6 F 347 G.S6.02
Van-der-waals TM5 V 257 5x70 G.S6 F 347 G.S6.02
Hydrophobic TM7 Q 317 7x34 G.HN V 4 G.HN.04
Van-der-waals TM7 Q 317 7x34 G.HN V 4 G.HN.04
Ionic TM5 R 255 5x68 G.H5 D 368 G.H5.13
Polar TM5 R 255 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 R 255 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 255 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 272 6x29 G.H5 K 376 G.H5.21
Van-der-waals TM6 R 272 6x29 G.H5 K 376 G.H5.21
Hydrophobic TM6 H 295 6x52 G.HN M 1 G.HN.01
Polar TM5 R 255 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM5 R 255 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 R 255 5x68 G.H5 Q 372 G.H5.17
Hydrophobic ECL1 F 129 23x52 G.HN C 11 G.HN.11
Hydrophobic TM3 P 142 3x33 G.HN M 1 G.HN.01
Van-der-waals TM3 P 142 3x33 G.HN M 1 G.HN.01
Polar ECL1 V 128 23x51 G.HN C 11 G.HN.11
Hydrophobic ECL1 V 128 23x51 G.HN C 11 G.HN.11
Van-der-waals ECL1 V 128 23x51 G.HN C 11 G.HN.11
Hydrophobic TM2 Y 120 2x63 G.HN R 6 G.HN.06
Van-der-waals TM2 Y 120 2x63 G.HN R 6 G.HN.06
Hydrophobic TM2 A 121 2x64 G.HN V 5 G.HN.05
Van-der-waals TM2 A 121 2x64 G.HN V 5 G.HN.05
Hydrophobic ICL2 L 167 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM6 T 276 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 166 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 166 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM6 W 291 6x48 G.HN M 1 G.HN.01
Hydrophobic TM3 L 163 3x54 G.H5 M 379 G.H5.24
Hydrophobic ECL2 V 208 - G.HN R 6 G.HN.06
Hydrophobic ICL2 R 170 - G.H5 I 378 G.H5.23
Hydrophobic TM3 V 145 3x36 G.HN M 1 G.HN.01
Van-der-waals TM3 V 145 3x36 G.HN M 1 G.HN.01
Hydrophobic TM5 P 258 5x71 G.H5 A 365 G.H5.10
Van-der-waals TM5 P 258 5x71 G.H5 A 365 G.H5.10
Hydrophobic TM5 L 252 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 252 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM3 L 163 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 163 3x54 G.H5 L 371 G.H5.16
Polar ICL1 R 89 12x48 G.HN R 41 G.HN.41
Hydrophobic ICL1 R 89 12x48 G.HN R 41 G.HN.41
Van-der-waals ICL1 R 89 12x48 G.HN R 41 G.HN.41
Hydrophobic TM2 E 123 2x66 G.HN L 8 G.HN.08
Van-der-waals TM2 E 123 2x66 G.HN L 8 G.HN.08
Hydrophobic ICL2 P 166 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 166 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 L 167 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 167 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 L 167 34x51 G.S1 V 58 G.S1.02
Hydrophobic C-term I 370 - G.h2s4 F 242 G.h2s4.01
Hydrophobic TM2 T 117 2x60 G.HN V 4 G.HN.04
Van-der-waals TM2 T 117 2x60 G.HN V 4 G.HN.04
Polar ICL2 R 170 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 R 170 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 170 - G.H5 N 374 G.H5.19
Hydrophobic TM6 L 279 6x36 G.H5 M 379 G.H5.24