Gi1 - PrRP receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM4 R 174 4x40 G.HN E 25 G.HN.49
Polar TM4 R 174 4x40 G.HN E 25 G.HN.49
Van-der-waals TM4 R 174 4x40 G.HN E 25 G.HN.49
Hydrophobic TM5 P 258 5x71 G.H5 D 341 G.H5.13
Polar TM2 T 95 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 95 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM3 L 163 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 L 163 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM5 G 259 5x72 G.S6 T 321 G.S6.03
Van-der-waals TM5 G 259 5x72 G.S6 T 321 G.S6.03
Hydrophobic ICL2 L 167 34x51 G.H5 T 340 G.H5.12
Polar TM6 R 272 6x29 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 272 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 T 262 - G.H4 Q 304 G.H4.12
Polar ICL3 Q 265 - G.S6 I 319 G.S6.01
Hydrophobic TM5 P 258 5x71 G.S6 Y 320 G.S6.02
Hydrophobic TM6 T 276 6x33 G.H5 L 348 G.H5.20
Polar TM2 T 95 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 166 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 166 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM3 V 162 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM4 S 172 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 S 172 4x38 G.HN E 28 G.HN.52
Polar ICL1 H 92 12x51 G.HN R 24 G.HN.48
Hydrophobic ICL1 H 92 12x51 G.HN R 24 G.HN.48
Van-der-waals ICL1 H 92 12x51 G.HN R 24 G.HN.48
Polar TM5 C 260 5x73 G.S6 T 321 G.S6.03
Van-der-waals TM5 C 260 5x73 G.S6 T 321 G.S6.03
Ionic TM6 R 272 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM5 G 259 5x72 G.S6 H 322 G.S6.04
Hydrophobic TM5 G 259 5x72 G.S6 H 322 G.S6.04
Van-der-waals TM5 G 259 5x72 G.S6 H 322 G.S6.04
Polar TM6 R 275 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 275 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 275 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 L 167 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 167 34x51 G.H5 I 343 G.H5.15
Hydrophobic C-term I 370 - G.H2 K 209 G.H2.05
Hydrophobic TM5 P 258 5x71 G.H5 A 338 G.H5.10
Van-der-waals TM5 P 258 5x71 G.H5 A 338 G.H5.10
Polar TM3 R 159 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 159 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 159 3x50 G.H5 C 351 G.H5.23
Polar TM4 L 173 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 L 173 4x39 G.HN E 28 G.HN.52
Hydrophobic C-term I 370 - G.H2 I 212 G.H2.08
Hydrophobic TM6 L 279 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 R 255 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 252 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM5 C 260 5x73 G.S6 F 323 G.S6.05
Van-der-waals TM5 C 260 5x73 G.S6 F 323 G.S6.05
Hydrophobic C-term I 370 - G.H2 R 208 G.H2.04
Van-der-waals C-term I 370 - G.H2 R 208 G.H2.04
Aromatic TM6 R 272 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 272 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 272 6x29 G.H5 F 354 G.H5.26
Polar TM3 V 162 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 162 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 V 162 3x53 G.H5 N 347 G.H5.19
Polar ICL3 Q 265 - G.H4 E 308 G.H4.16
Hydrophobic ICL3 Q 265 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 Q 265 - G.H4 E 308 G.H4.16
Hydrophobic TM5 L 252 5x65 G.H5 L 348 G.H5.20
Polar TM2 N 93 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 N 93 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 93 2x37 G.H5 D 350 G.H5.22
Polar H8 H 339 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 H 339 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 H 339 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM3 L 163 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM6 W 268 6x25 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 W 268 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 L 280 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 280 6x37 G.H5 L 353 G.H5.25
Ionic TM5 R 255 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 255 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 255 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 255 5x68 G.H5 D 341 G.H5.13
Ionic ICL2 R 169 34x53 G.HN E 28 G.HN.52
Polar ICL2 R 169 34x53 G.HN E 28 G.HN.52
Hydrophobic ICL2 R 169 34x53 G.HN E 28 G.HN.52
Van-der-waals ICL2 R 169 34x53 G.HN E 28 G.HN.52
Polar TM6 T 276 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 276 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 276 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 P 258 5x71 G.S6 H 322 G.S6.04
Hydrophobic ICL2 P 166 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 166 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM5 P 258 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 P 258 5x71 G.H5 D 337 G.H5.09
Hydrophobic ICL2 L 167 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 167 34x51 G.H5 F 336 G.H5.08
Polar C-term V 369 - G.H3 S 252 G.H3.11
Hydrophobic ICL2 P 166 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM4 L 173 4x39 G.HN R 24 G.HN.48
Van-der-waals TM4 L 173 4x39 G.HN R 24 G.HN.48
Hydrophobic TM3 L 163 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 163 3x54 G.H5 L 348 G.H5.20
Ionic ICL2 R 170 - G.H5 D 350 G.H5.22
Polar ICL2 R 170 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 170 - G.H5 D 350 G.H5.22
Polar ICL2 L 167 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 R 255 5x68 G.H5 K 345 G.H5.17
Van-der-waals TM5 R 255 5x68 G.H5 K 345 G.H5.17
Polar TM5 C 260 5x73 G.H4 Q 304 G.H4.12
Hydrophobic TM5 C 260 5x73 G.H4 Q 304 G.H4.12
Van-der-waals TM5 C 260 5x73 G.H4 Q 304 G.H4.12
Hydrophobic ICL2 R 169 34x53 G.hns1 A 31 G.hns1.02
Ionic ICL1 R 89 12x48 G.HN D 20 G.HN.44
Polar ICL1 R 89 12x48 G.HN D 20 G.HN.44
Van-der-waals ICL1 R 89 12x48 G.HN D 20 G.HN.44
Polar ICL3 T 262 - G.H4 E 308 G.H4.16
Hydrophobic ICL3 T 262 - G.H4 E 308 G.H4.16
Van-der-waals ICL3 T 262 - G.H4 E 308 G.H4.16
Hydrophobic TM3 R 159 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 167 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM5 V 257 5x70 G.S6 Y 320 G.S6.02
Hydrophobic C-term V 368 - G.H2 I 212 G.H2.08
Polar TM3 R 159 3x50 G.H5 G 352 G.H5.24
Van-der-waals TM3 R 159 3x50 G.H5 G 352 G.H5.24