Gq - PAF receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 P 122 34x50 G.H5 N 352 G.H5.19
Van-der-waals ICL2 P 122 34x50 G.H5 N 352 G.H5.19
Hydrophobic TM5 Q 216 5x68 G.H5 L 349 G.H5.16
Van-der-waals TM5 Q 216 5x68 G.H5 L 349 G.H5.16
Polar ICL2 Q 127 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 Q 127 34x55 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 Q 127 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic TM6 R 229 6x33 G.H5 V 359 G.H5.26
Hydrophobic TM6 M 233 6x37 G.H5 L 358 G.H5.25
Van-der-waals TM6 M 233 6x37 G.H5 L 358 G.H5.25
Polar TM6 N 223 6x27 G.H5 Q 350 G.H5.17
Polar TM3 N 114 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 N 114 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 N 114 3x49 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 Q 127 34x55 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 Q 127 34x55 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 P 122 34x50 G.H5 L 349 G.H5.16
Hydrophobic TM6 A 230 6x34 G.H5 V 359 G.H5.26
Hydrophobic ICL3 Q 219 - G.S6 Y 325 G.S6.02
Van-der-waals ICL3 Q 219 - G.S6 Y 325 G.S6.02
Hydrophobic ICL3 Q 219 - G.H5 F 339 G.H5.06
Hydrophobic TM3 V 119 3x54 G.H5 L 353 G.H5.20
Polar TM6 N 223 6x27 G.H5 D 346 G.H5.13
Van-der-waals TM6 N 223 6x27 G.H5 D 346 G.H5.13
Polar TM7 Y 293 7x53 G.H5 N 357 G.H5.24
Van-der-waals TM7 Y 293 7x53 G.H5 N 357 G.H5.24
Hydrophobic ICL3 Q 220 - G.h4s6 I 323 G.h4s6.20
Van-der-waals ICL3 Q 220 - G.h4s6 I 323 G.h4s6.20
Polar TM2 N 50 2x37 G.H5 E 355 G.H5.22
Hydrophobic TM2 N 50 2x37 G.H5 E 355 G.H5.22
Van-der-waals TM2 N 50 2x37 G.H5 E 355 G.H5.22
Hydrophobic ICL2 I 123 34x51 G.H5 F 341 G.H5.08
Hydrophobic TM3 R 115 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM5 L 213 5x65 G.H5 L 353 G.H5.20
Hydrophobic ICL2 I 123 34x51 G.H5 I 348 G.H5.15
Hydrophobic TM3 A 118 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 A 118 3x53 G.H5 Y 356 G.H5.23
Polar TM6 R 222 6x26 G.h4s6 K 322 G.h4s6.13
Polar TM3 A 118 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 A 118 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 A 118 3x53 G.H5 N 352 G.H5.19
Polar ICL2 N 129 34x57 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 N 129 34x57 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 N 129 34x57 G.hns1 R 37 G.hns1.02
Hydrophobic TM6 A 230 6x34 G.H5 L 353 G.H5.20
Hydrophobic TM7 T 297 7x57 G.H5 V 359 G.H5.26
Hydrophobic TM2 M 56 2x43 G.H5 N 357 G.H5.24
Van-der-waals TM2 M 56 2x43 G.H5 N 357 G.H5.24
Polar TM7 K 298 7x58 G.H5 V 359 G.H5.26
Hydrophobic TM7 K 298 7x58 G.H5 V 359 G.H5.26
Van-der-waals TM7 K 298 7x58 G.H5 V 359 G.H5.26
Hydrophobic ICL2 P 122 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 122 34x50 G.H5 I 348 G.H5.15
Polar TM6 R 222 6x26 G.h4s6 S 320 G.h4s6.11
Hydrophobic TM6 R 222 6x26 G.h4s6 S 320 G.h4s6.11
Van-der-waals TM6 R 222 6x26 G.h4s6 S 320 G.h4s6.11
Hydrophobic TM2 I 52 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 I 52 2x39 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 A 126 34x54 G.H5 I 348 G.H5.15
Van-der-waals ICL2 A 126 34x54 G.H5 I 348 G.H5.15
Ionic TM7 K 298 7x58 G.h4s6 D 321 G.h4s6.12
Polar TM7 K 298 7x58 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM3 V 119 3x54 G.H5 L 358 G.H5.25
Hydrophobic TM7 T 297 7x57 G.H5 N 357 G.H5.24
Van-der-waals TM7 T 297 7x57 G.H5 N 357 G.H5.24
Polar TM3 R 115 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 115 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 115 3x50 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 I 123 34x51 G.S3 V 199 G.S3.01
Van-der-waals ICL2 I 123 34x51 G.S3 V 199 G.S3.01
Hydrophobic TM6 V 226 6x30 G.H5 V 359 G.H5.26
Van-der-waals TM6 V 226 6x30 G.H5 V 359 G.H5.26
Hydrophobic ICL2 I 123 34x51 G.H5 K 345 G.H5.12
Ionic TM6 R 222 6x26 G.h4s6 D 321 G.h4s6.12
Polar TM6 R 222 6x26 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM6 R 222 6x26 G.h4s6 D 321 G.h4s6.12
Van-der-waals TM6 R 222 6x26 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM6 V 234 6x38 G.H5 L 358 G.H5.25
Van-der-waals TM6 V 234 6x38 G.H5 L 358 G.H5.25
Polar TM3 R 115 3x50 G.H5 N 357 G.H5.24
Van-der-waals TM3 R 115 3x50 G.H5 N 357 G.H5.24
Polar TM6 A 230 6x34 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 230 6x34 G.H5 L 358 G.H5.25
Van-der-waals TM6 A 230 6x34 G.H5 L 358 G.H5.25
Hydrophobic ICL2 I 123 34x51 G.S1 L 40 G.S1.02
Hydrophobic TM6 V 226 6x30 G.H5 Q 350 G.H5.17
Van-der-waals TM6 V 226 6x30 G.H5 Q 350 G.H5.17
Hydrophobic ICL2 P 122 34x50 G.H5 K 345 G.H5.12
Hydrophobic TM6 N 223 6x27 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM6 N 223 6x27 G.h4s6 I 323 G.h4s6.20
Hydrophobic TM6 V 226 6x30 G.H5 L 353 G.H5.20
Hydrophobic TM3 V 119 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 V 119 3x54 G.H5 L 349 G.H5.16
Polar ICL3 Q 220 - G.S6 I 324 G.S6.01
Hydrophobic ICL3 Q 220 - G.S6 I 324 G.S6.01
Van-der-waals ICL3 Q 220 - G.S6 I 324 G.S6.01
Hydrophobic ICL2 T 125 34x53 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 T 125 34x53 G.H5 Y 356 G.H5.23