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QRFP receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | V | 398 | - | G.S2 | I | 185 | G.S2.01 |
Polar | ICL2 | K | 154 | 34x54 | G.h2s4 | T | 220 | G.h2s4.05 |
Van-der-waals | ICL2 | K | 154 | 34x54 | G.h2s4 | T | 220 | G.h2s4.05 |
Hydrophobic | TM5 | V | 247 | 5x71 | G.H5 | F | 336 | G.H5.08 |
Polar | TM6 | K | 268 | 6x30 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 268 | 6x30 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 268 | 6x30 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | C-term | V | 398 | - | G.H2 | C | 215 | G.H2.10 |
Van-der-waals | C-term | V | 398 | - | G.H2 | C | 215 | G.H2.10 |
Ionic | C-term | E | 420 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Polar | C-term | E | 420 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Van-der-waals | C-term | E | 420 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Hydrophobic | C-term | I | 396 | - | G.H2 | W | 212 | G.H2.07 |
Van-der-waals | C-term | I | 396 | - | G.H2 | W | 212 | G.H2.07 |
Polar | ICL3 | E | 260 | - | G.S6 | I | 319 | G.S6.01 |
Hydrophobic | C-term | L | 414 | - | H.hbhc | T | 117 | H.hbhc.05 |
Van-der-waals | C-term | L | 414 | - | H.hbhc | T | 117 | H.hbhc.05 |
Hydrophobic | TM6 | K | 267 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 267 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | A | 271 | 6x33 | G.H5 | Y | 354 | G.H5.26 |
Polar | TM3 | R | 143 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 143 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 143 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Aromatic | ICL2 | W | 155 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | W | 155 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | W | 155 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | C-term | R | 418 | - | H.hbhc | M | 114 | H.hbhc.02 |
Van-der-waals | C-term | R | 418 | - | H.hbhc | M | 114 | H.hbhc.02 |
Hydrophobic | ICL2 | F | 151 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | F | 151 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM5 | V | 252 | 5x76 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | H8 | N | 338 | 8x49 | G.H5 | R | 349 | G.H5.21 |
Van-der-waals | H8 | N | 338 | 8x49 | G.H5 | R | 349 | G.H5.21 |
Hydrophobic | C-term | I | 396 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | C-term | I | 396 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | TM3 | R | 143 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 143 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | F | 391 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | TM3 | E | 142 | 3x49 | G.H5 | C | 351 | G.H5.23 |
Polar | ICL2 | P | 150 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | P | 150 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | F | 151 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | F | 151 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Polar | TM6 | K | 263 | 6x25 | G.h4s6 | S | 314 | G.h4s6.08 |
Van-der-waals | TM6 | K | 263 | 6x25 | G.h4s6 | S | 314 | G.h4s6.08 |
Hydrophobic | ICL2 | W | 155 | 34x55 | G.HN | I | 28 | G.HN.52 |
Polar | TM5 | G | 248 | 5x72 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | TM5 | G | 248 | 5x72 | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | TM5 | G | 248 | 5x72 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | C-term | F | 391 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | C-term | F | 391 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | ICL2 | F | 151 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | C-term | I | 396 | - | G.H2 | K | 211 | G.H2.06 |
Van-der-waals | C-term | I | 396 | - | G.H2 | K | 211 | G.H2.06 |
Hydrophobic | TM6 | M | 275 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 275 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Ionic | TM6 | K | 267 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | K | 267 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | K | 267 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | H | 257 | - | G.H4 | A | 306 | G.H4.13 |
Hydrophobic | TM6 | M | 274 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | M | 274 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Polar | H8 | K | 341 | 8x52 | G.h4s6 | N | 316 | G.h4s6.10 |
Polar | TM6 | K | 267 | 6x29 | G.h4s6 | N | 316 | G.h4s6.10 |
Van-der-waals | TM6 | K | 267 | 6x29 | G.h4s6 | N | 316 | G.h4s6.10 |
Van-der-waals | TM6 | K | 263 | 6x25 | G.h4s6 | N | 312 | G.h4s6.02 |
Hydrophobic | C-term | I | 396 | - | G.H2 | K | 210 | G.H2.05 |
Van-der-waals | C-term | I | 396 | - | G.H2 | K | 210 | G.H2.05 |
Polar | TM6 | K | 267 | 6x29 | G.h4s6 | P | 315 | G.h4s6.09 |
Hydrophobic | TM6 | K | 267 | 6x29 | G.h4s6 | P | 315 | G.h4s6.09 |
Van-der-waals | TM6 | K | 267 | 6x29 | G.h4s6 | P | 315 | G.h4s6.09 |
Polar | TM2 | T | 80 | 2x39 | G.H5 | G | 350 | G.H5.22 |
Van-der-waals | TM2 | T | 80 | 2x39 | G.H5 | G | 350 | G.H5.22 |
Hydrophobic | TM3 | L | 147 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Polar | TM6 | K | 263 | 6x25 | G.h4s6 | P | 315 | G.h4s6.09 |
Hydrophobic | TM6 | K | 263 | 6x25 | G.h4s6 | P | 315 | G.h4s6.09 |
Van-der-waals | TM6 | K | 263 | 6x25 | G.h4s6 | P | 315 | G.h4s6.09 |
Polar | ICL3 | H | 257 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | ICL3 | H | 257 | - | G.H4 | E | 309 | G.H4.16 |
Van-der-waals | ICL3 | H | 257 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | TM5 | V | 247 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | TM5 | V | 247 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | ICL2 | W | 155 | 34x55 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM6 | I | 264 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | I | 264 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | L | 241 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | L | 241 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | R | 246 | 5x70 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | R | 246 | 5x70 | G.H5 | I | 344 | G.H5.16 |
Polar | TM5 | T | 255 | 5x79 | G.H4 | Q | 305 | G.H4.12 |
Van-der-waals | TM5 | T | 255 | 5x79 | G.H4 | Q | 305 | G.H4.12 |
Polar | TM3 | G | 146 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | G | 146 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | G | 146 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Polar | TM6 | K | 263 | 6x25 | G.h4s6 | K | 317 | G.h4s6.11 |
Van-der-waals | TM6 | K | 263 | 6x25 | G.h4s6 | K | 317 | G.h4s6.11 |
Hydrophobic | ICL2 | F | 151 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | F | 151 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Polar | TM2 | T | 80 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | T | 80 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | T | 80 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Ionic | C-term | E | 397 | - | G.H2 | K | 211 | G.H2.06 |
Polar | ICL3 | E | 260 | - | G.h4s6 | N | 312 | G.h4s6.02 |
Hydrophobic | C-term | F | 391 | - | G.H2 | I | 213 | G.H2.08 |
Polar | TM5 | T | 255 | 5x79 | G.S6 | C | 321 | G.S6.03 |
Hydrophobic | TM5 | T | 255 | 5x79 | G.S6 | C | 321 | G.S6.03 |
Van-der-waals | TM5 | T | 255 | 5x79 | G.S6 | C | 321 | G.S6.03 |
Hydrophobic | C-term | I | 396 | - | G.H2 | C | 215 | G.H2.10 |
Hydrophobic | TM3 | L | 147 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | I | 256 | 5x80 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM5 | I | 256 | 5x80 | G.S6 | Y | 320 | G.S6.02 |
Polar | TM6 | I | 264 | 6x26 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL2 | M | 153 | 34x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | ICL2 | M | 153 | 34x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | F | 391 | - | G.H3 | L | 250 | G.H3.08 |
Hydrophobic | TM6 | M | 274 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 274 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | K | 154 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Polar | H8 | N | 336 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | N | 336 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | N | 336 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Polar | C-term | H | 413 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Van-der-waals | C-term | H | 413 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Hydrophobic | ICL2 | P | 150 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | P | 150 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM5 | V | 252 | 5x76 | G.H5 | V | 334 | G.H5.06 |
Van-der-waals | TM5 | V | 252 | 5x76 | G.H5 | V | 334 | G.H5.06 |
Hydrophobic | TM5 | V | 247 | 5x71 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | TM5 | V | 247 | 5x71 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | ICL3 | E | 260 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | E | 260 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | A | 271 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | A | 271 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | A | 271 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | M | 153 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | M | 153 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM5 | V | 247 | 5x71 | G.H5 | Q | 333 | G.H5.05 |
Hydrophobic | C-term | L | 410 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | L | 410 | - | H.HA | Q | 68 | H.HA.06 |