G14 - RXFP3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 74.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 15.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 A 307 5x78 G.H5 F 335 G.H5.06
Hydrophobic TM3 V 184 3x54 G.H5 F 352 G.H5.23
Hydrophobic TM6 K 323 6x32 G.H5 V 355 G.H5.26
Polar C-term Y 460 - G.H4 Q 310 G.H4.16
Hydrophobic C-term Y 460 - G.H4 Q 310 G.H4.16
Van-der-waals C-term Y 460 - G.H4 Q 310 G.H4.16
Ionic H8 R 394 8x48 G.h4s6 E 317 G.h4s6.12
Polar H8 R 394 8x48 G.h4s6 E 317 G.h4s6.12
Hydrophobic H8 R 394 8x48 G.h4s6 E 317 G.h4s6.12
Van-der-waals H8 R 394 8x48 G.h4s6 E 317 G.h4s6.12
Hydrophobic C-term V 453 - G.H3 K 252 G.H3.10
Van-der-waals C-term V 453 - G.H3 K 252 G.H3.10
Hydrophobic ICL2 C 201 - G.HN D 28 G.HN.50
Van-der-waals ICL2 C 201 - G.HN D 28 G.HN.50
Hydrophobic ICL2 D 200 - G.HN L 25 G.HN.47
Van-der-waals ICL2 D 200 - G.HN L 25 G.HN.47
Polar ICL2 C 201 - G.HN L 25 G.HN.47
Hydrophobic ICL2 C 201 - G.HN L 25 G.HN.47
Van-der-waals ICL2 C 201 - G.HN L 25 G.HN.47
Hydrophobic ICL2 G 199 - G.HN L 25 G.HN.47
Van-der-waals ICL2 G 199 - G.HN L 25 G.HN.47
Polar ICL2 C 201 - G.HN E 22 G.HN.44
Van-der-waals ICL2 A 187 - G.H5 N 348 G.H5.19
Hydrophobic ICL2 C 201 - G.HN Q 24 G.HN.46
Hydrophobic ICL2 C 202 - G.HN D 28 G.HN.50
Van-der-waals ICL2 C 202 - G.HN D 28 G.HN.50
Polar TM6 V 324 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 V 324 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 V 324 6x33 G.H5 L 354 G.H5.25
Hydrophobic ICL2 R 198 - G.HN L 25 G.HN.47
Van-der-waals ICL2 R 198 - G.HN L 25 G.HN.47
Hydrophobic ICL2 L 206 - G.hns1 A 32 G.hns1.01
Van-der-waals ICL2 L 206 - G.hns1 A 32 G.hns1.01
Polar TM5 A 309 5x80 G.S6 S 322 G.S6.03
Polar TM6 S 327 6x36 G.H5 N 353 G.H5.24
Van-der-waals TM6 S 327 6x36 G.H5 N 353 G.H5.24
Hydrophobic TM5 Y 287 5x58 G.H5 L 354 G.H5.25
Hydrophobic TM5 V 308 5x79 G.S6 Y 321 G.S6.02
Polar TM3 R 180 3x50 G.H5 F 352 G.H5.23
Hydrophobic TM3 R 180 3x50 G.H5 F 352 G.H5.23
Van-der-waals TM3 R 180 3x50 G.H5 F 352 G.H5.23
Polar TM7 L 388 7x52 G.H5 N 353 G.H5.24
Van-der-waals TM7 L 388 7x52 G.H5 N 353 G.H5.24
Polar TM3 S 183 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 S 183 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM6 K 323 6x32 G.H5 L 354 G.H5.25
Hydrophobic TM5 A 306 5x77 G.H5 F 335 G.H5.06
Hydrophobic C-term Y 460 - G.H4 L 306 G.H4.12
Van-der-waals C-term Y 460 - G.H4 L 306 G.H4.12
Hydrophobic C-term V 454 - G.h4s6 P 314 G.h4s6.09
Van-der-waals C-term V 454 - G.h4s6 P 314 G.h4s6.09
Polar C-term S 456 - G.h4s6 K 316 G.h4s6.11
Hydrophobic C-term S 456 - G.h4s6 K 316 G.h4s6.11
Van-der-waals C-term S 456 - G.h4s6 K 316 G.h4s6.11
Hydrophobic C-term V 454 - G.h4s6 N 313 G.h4s6.08
Van-der-waals C-term V 454 - G.h4s6 N 313 G.h4s6.08
Hydrophobic C-term V 454 - G.h4s6 K 316 G.h4s6.11
Hydrophobic ICL2 L 188 - G.H5 K 341 G.H5.12
Van-der-waals ICL2 L 188 - G.H5 K 341 G.H5.12
Hydrophobic TM3 V 184 3x54 G.H5 N 348 G.H5.19
Polar TM5 V 308 5x79 G.S6 S 322 G.S6.03
Van-der-waals TM5 V 308 5x79 G.S6 S 322 G.S6.03
Polar H8 R 393 8x47 G.H5 N 353 G.H5.24
Hydrophobic H8 R 393 8x47 G.H5 N 353 G.H5.24
Van-der-waals H8 R 393 8x47 G.H5 N 353 G.H5.24
Hydrophobic C-term Y 455 - G.H4 D 311 G.H4.17
Van-der-waals C-term Y 455 - G.H4 D 311 G.H4.17
Hydrophobic C-term V 452 - G.h4s6 P 314 G.h4s6.09
Van-der-waals C-term V 452 - G.h4s6 P 314 G.h4s6.09
Hydrophobic TM2 I 117 2x39 G.H5 F 352 G.H5.23
Van-der-waals TM2 I 117 2x39 G.H5 F 352 G.H5.23
Hydrophobic TM5 A 309 5x80 G.H4 L 306 G.H4.12
Van-der-waals TM5 A 309 5x80 G.H4 L 306 G.H4.12
Polar ICL2 R 204 - G.HN D 28 G.HN.50
Hydrophobic ICL2 R 204 - G.HN D 28 G.HN.50
Van-der-waals ICL2 R 204 - G.HN D 28 G.HN.50
Hydrophobic TM5 I 294 5x65 G.H5 L 349 G.H5.20
Polar TM5 A 307 5x78 G.S6 H 323 G.S6.04
Hydrophobic ICL2 S 190 - G.s2s3 E 193 G.s2s3.01
Van-der-waals ICL2 S 190 - G.s2s3 E 193 G.s2s3.01
Ionic TM6 R 320 6x29 G.H5 D 342 G.H5.13
Polar TM6 R 320 6x29 G.H5 D 342 G.H5.13
Van-der-waals TM6 R 320 6x29 G.H5 D 342 G.H5.13
Hydrophobic ICL2 S 205 - G.HN D 31 G.HN.53
Hydrophobic ICL2 A 187 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 A 187 - G.H5 I 344 G.H5.15
Polar ICL2 H 191 - G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL2 H 191 - G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 H 191 - G.s2s3 N 194 G.s2s3.02
Polar ICL2 G 203 - G.hns1 A 32 G.hns1.01
Hydrophobic ICL2 G 203 - G.hns1 A 32 G.hns1.01
Van-der-waals ICL2 G 203 - G.hns1 A 32 G.hns1.01
Polar TM5 A 309 5x80 G.H4 Q 310 G.H4.16
Polar C-term Y 455 - G.h4s6 N 313 G.h4s6.08
Hydrophobic C-term V 453 - G.H4 D 311 G.H4.17
Van-der-waals C-term V 453 - G.H4 D 311 G.H4.17
Hydrophobic C-term L 463 - G.H5 F 335 G.H5.06
Ionic H8 R 394 8x48 G.h4s6 D 315 G.h4s6.10
Hydrophobic TM3 S 183 3x53 G.H5 F 352 G.H5.23
Van-der-waals TM3 S 183 3x53 G.H5 F 352 G.H5.23
Hydrophobic TM6 R 320 6x29 G.H5 V 355 G.H5.26
Hydrophobic TM5 A 309 5x80 G.S6 F 324 G.S6.05
Hydrophobic TM6 S 327 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM5 L 290 5x61 G.H5 L 354 G.H5.25
Van-der-waals TM5 L 290 5x61 G.H5 L 354 G.H5.25
Hydrophobic TM6 V 328 6x37 G.H5 L 354 G.H5.25
Van-der-waals TM6 V 328 6x37 G.H5 L 354 G.H5.25
Polar ICL2 L 206 - G.HN D 31 G.HN.53
Hydrophobic TM6 R 320 6x29 G.H5 Q 346 G.H5.17
Van-der-waals TM6 R 320 6x29 G.H5 Q 346 G.H5.17
Hydrophobic TM3 V 184 3x54 G.H5 L 345 G.H5.16
Van-der-waals TM3 V 184 3x54 G.H5 L 345 G.H5.16
Hydrophobic TM5 V 308 5x79 G.H5 F 335 G.H5.06
Hydrophobic TM6 V 324 6x33 G.H5 V 355 G.H5.26
Van-der-waals TM6 V 324 6x33 G.H5 V 355 G.H5.26
Hydrophobic ICL1 W 112 12x50 G.H5 E 351 G.H5.22
Hydrophobic TM6 R 320 6x29 G.H5 L 349 G.H5.20
Van-der-waals TM6 R 320 6x29 G.H5 L 349 G.H5.20
Polar ICL2 C 201 - G.HN I 21 G.HN.43
Hydrophobic ICL2 C 201 - G.HN I 21 G.HN.43
Van-der-waals ICL2 C 201 - G.HN I 21 G.HN.43
Hydrophobic C-term V 453 - G.h4s6 Q 312 G.h4s6.01
Van-der-waals C-term V 453 - G.h4s6 Q 312 G.h4s6.01
Hydrophobic TM3 T 179 3x49 G.H5 F 352 G.H5.23
Hydrophobic TM7 V 392 7x56 G.H5 N 353 G.H5.24
Van-der-waals TM7 V 392 7x56 G.H5 N 353 G.H5.24
Hydrophobic TM6 V 324 6x33 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 188 - G.H5 L 345 G.H5.16
Van-der-waals ICL2 L 188 - G.H5 L 345 G.H5.16
Hydrophobic C-term V 453 - G.h4s6 P 314 G.h4s6.09
Polar C-term Y 460 - G.H4 K 307 G.H4.13
Hydrophobic C-term Y 460 - G.H4 K 307 G.H4.13
Van-der-waals C-term Y 460 - G.H4 K 307 G.H4.13
Hydrophobic TM3 V 184 3x54 G.H5 L 349 G.H5.20
Polar H8 R 393 8x47 G.H5 E 351 G.H5.22
Van-der-waals H8 R 393 8x47 G.H5 E 351 G.H5.22
Van-der-waals ICL2 S 190 - G.H5 K 341 G.H5.12
Polar TM2 S 115 2x37 G.H5 E 351 G.H5.22
Hydrophobic TM2 S 115 2x37 G.H5 E 351 G.H5.22
Van-der-waals TM2 S 115 2x37 G.H5 E 351 G.H5.22
Polar TM6 R 320 6x29 G.H5 L 345 G.H5.16
Hydrophobic TM6 R 320 6x29 G.H5 L 345 G.H5.16
Van-der-waals TM6 R 320 6x29 G.H5 L 345 G.H5.16
Hydrophobic TM2 I 117 2x39 G.H5 E 351 G.H5.22
Van-der-waals TM2 I 117 2x39 G.H5 E 351 G.H5.22
Polar ICL2 G 203 - G.HN D 28 G.HN.50
Hydrophobic ICL2 G 203 - G.HN D 28 G.HN.50
Van-der-waals ICL2 G 203 - G.HN D 28 G.HN.50