Gs - RXFP4 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 V 243 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM5 L 227 5x61 G.H5 L 388 G.H5.20
Ionic ICL3 R 236 - G.H5 D 381 G.H5.13
Polar ICL3 R 236 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 R 236 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 R 236 - G.H5 D 381 G.H5.13
Hydrophobic ICL1 P 72 12x51 G.HN K 34 G.HN.51
Polar TM7 C 310 7x54 G.H5 E 392 G.H5.24
Hydrophobic TM7 C 310 7x54 G.H5 E 392 G.H5.24
Van-der-waals TM7 C 310 7x54 G.H5 E 392 G.H5.24
Hydrophobic TM3 V 142 3x53 G.H5 Y 391 G.H5.23
Polar TM2 S 76 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 S 76 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 S 76 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 227 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 227 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM6 R 237 6x26 G.H5 R 385 G.H5.17
Van-der-waals TM6 R 237 6x26 G.H5 R 385 G.H5.17
Hydrophobic ICL2 A 146 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 A 146 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM3 R 139 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM6 D 240 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 D 240 6x29 G.H5 R 385 G.H5.17
Ionic TM6 D 240 6x29 G.H5 R 385 G.H5.17
Polar TM6 D 240 6x29 G.H5 R 385 G.H5.17
Hydrophobic TM6 D 240 6x29 G.H5 R 385 G.H5.17
Hydrophobic TM6 V 244 6x33 G.H5 L 388 G.H5.20
Polar H8 R 313 8x47 G.H5 R 389 G.H5.21
Hydrophobic ICL2 A 146 34x50 G.H5 H 387 G.H5.19
Polar TM7 L 312 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM7 L 312 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 L 312 7x56 G.H5 E 392 G.H5.24
Polar H8 Q 318 8x52 G.h4s6 R 356 G.h4s6.12
Van-der-waals H8 Q 318 8x52 G.h4s6 R 356 G.h4s6.12
Hydrophobic ICL2 G 148 34x52 G.S3 V 217 G.S3.01
Hydrophobic TM5 R 234 5x68 G.H5 R 380 G.H5.12
Van-der-waals TM5 R 234 5x68 G.H5 R 380 G.H5.12
Ionic H8 R 313 8x47 G.H5 E 392 G.H5.24
Polar H8 R 313 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 R 313 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 R 313 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 A 146 34x50 G.H5 I 383 G.H5.15
Hydrophobic TM3 V 143 3x54 G.H5 L 388 G.H5.20
Polar TM3 V 143 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 143 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 143 3x54 G.H5 Q 384 G.H5.16
Polar TM6 R 237 6x26 G.S6 C 359 G.S6.01
Van-der-waals TM6 R 237 6x26 G.S6 C 359 G.S6.01
Polar TM3 R 139 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 Y 391 G.H5.23
Hydrophobic H8 R 313 8x47 G.H5 Y 391 G.H5.23
Polar TM7 Y 309 7x53 G.H5 E 392 G.H5.24
Hydrophobic TM7 Y 309 7x53 G.H5 E 392 G.H5.24
Van-der-waals TM7 Y 309 7x53 G.H5 E 392 G.H5.24
Hydrophobic TM3 L 135 3x46 G.H5 Y 391 G.H5.23
Hydrophobic TM5 F 230 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 F 230 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM6 V 244 6x33 G.H5 L 394 G.H5.26
Van-der-waals TM6 V 244 6x33 G.H5 L 394 G.H5.26
Polar TM6 S 247 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 247 6x36 G.H5 L 393 G.H5.25
Polar ICL3 R 236 - G.H5 Q 384 G.H5.16
Hydrophobic ICL3 R 236 - G.H5 Q 384 G.H5.16
Van-der-waals ICL3 R 236 - G.H5 Q 384 G.H5.16
Polar TM5 R 234 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 R 234 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 149 34x53 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 P 149 34x53 G.s2s3 K 216 G.s2s3.02
Polar H8 R 314 8x48 G.h4s6 D 354 G.h4s6.10
Van-der-waals H8 R 314 8x48 G.h4s6 D 354 G.h4s6.10
Hydrophobic ICL3 R 236 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 R 236 - G.H5 R 385 G.H5.17
Hydrophobic TM2 P 74 2x37 G.H5 Q 390 G.H5.22
Polar TM6 V 244 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 V 244 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 244 6x33 G.H5 L 393 G.H5.25
Polar ICL2 H 152 34x56 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 H 152 34x56 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 H 152 34x56 G.hns1 R 38 G.hns1.02
Polar H8 R 313 8x47 G.H5 Q 390 G.H5.22
Hydrophobic H8 R 313 8x47 G.H5 Q 390 G.H5.22
Van-der-waals H8 R 313 8x47 G.H5 Q 390 G.H5.22
Polar TM2 S 76 2x39 G.H5 Q 390 G.H5.22
Hydrophobic TM3 V 143 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 L 231 5x65 G.H5 L 388 G.H5.20
Hydrophobic ICL2 A 147 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 A 147 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL3 R 236 - G.H5 L 388 G.H5.20
Van-der-waals ICL3 R 236 - G.H5 L 388 G.H5.20
Hydrophobic TM6 L 251 6x40 G.H5 L 393 G.H5.25
Polar ICL1 P 72 12x51 G.hns1 R 38 G.hns1.02
Polar TM7 L 311 7x55 G.H5 E 392 G.H5.24
Hydrophobic TM3 V 142 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 V 142 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 A 147 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 A 147 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 H 152 34x56 G.hns1 A 39 G.hns1.03