G12 - RXFP1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.6
PAE mean: 18.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 Y 440 2x39 G.H5 Q 381 G.H5.26
Van-der-waals TM2 Y 440 2x39 G.H5 Q 381 G.H5.26
Aromatic ICL2 F 518 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 518 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 518 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM5 V 606 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 V 606 5x65 G.H5 L 375 G.H5.20
Polar TM6 Q 619 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 Q 619 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 Q 619 6x26 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 V 521 34x54 G.HN R 52 G.HN.52
Van-der-waals ICL2 V 521 34x54 G.HN R 52 G.HN.52
Hydrophobic TM6 I 616 6x23 G.h4s6 R 342 G.h4s6.11
Van-der-waals TM6 I 616 6x23 G.h4s6 R 342 G.h4s6.11
Hydrophobic TM3 I 514 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 514 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 F 518 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 518 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM6 I 616 6x23 G.h4s6 K 344 G.h4s6.19
Van-der-waals TM6 I 616 6x23 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM6 I 625 6x32 G.H5 M 379 G.H5.24
Ionic ICL2 R 522 34x55 G.H5 D 377 G.H5.22
Polar ICL2 R 522 34x55 G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 522 34x55 G.H5 D 377 G.H5.22
Van-der-waals TM7 Y 681 7x53 G.H5 Q 381 G.H5.26
Hydrophobic TM6 F 630 6x37 G.H5 I 378 G.H5.23
Hydrophobic ICL2 V 521 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 V 521 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 F 518 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 518 34x51 G.H5 K 367 G.H5.12
Hydrophobic H8 R 686 8x48 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 517 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM5 T 612 5x71 G.S6 F 347 G.S6.02
Polar TM5 S 605 5x64 G.H5 K 367 G.H5.12
Polar TM5 S 609 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 S 609 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 S 609 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 S 609 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 S 609 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM6 I 616 6x23 G.h4s6 R 339 G.h4s6.08
Polar TM6 R 629 6x36 G.H5 Q 381 G.H5.26
Hydrophobic TM6 R 629 6x36 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 629 6x36 G.H5 Q 381 G.H5.26
Hydrophobic TM3 K 510 3x50 G.H5 I 378 G.H5.23
Hydrophobic H8 T 685 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 T 685 8x47 G.H5 Q 381 G.H5.26
Hydrophobic TM6 I 616 6x23 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 I 616 6x23 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 I 616 6x23 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 P 517 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 517 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM6 K 622 6x29 G.H5 M 379 G.H5.24
Polar TM6 R 629 6x36 G.H5 I 378 G.H5.23
Van-der-waals TM6 R 629 6x36 G.H5 I 378 G.H5.23
Hydrophobic TM5 A 613 5x72 G.S6 F 347 G.S6.02
Van-der-waals TM1 R 430 1x57 G.H5 Q 381 G.H5.26
Polar TM6 E 623 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 E 623 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM3 I 514 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 514 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 F 518 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 518 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 R 522 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 A 613 5x72 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 A 613 5x72 G.h4s6 P 345 G.h4s6.20
Polar TM6 Q 619 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 Q 619 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 Q 619 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 L 626 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 626 6x33 G.H5 M 379 G.H5.24
Polar TM6 R 629 6x36 G.H5 M 379 G.H5.24
Polar TM3 C 513 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 C 513 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 C 513 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM5 V 606 5x65 G.H5 L 371 G.H5.16
Hydrophobic ICL2 F 518 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 F 518 34x51 G.S1 V 58 G.S1.02
Hydrophobic H8 P 687 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 P 687 8x49 G.H5 L 380 G.H5.25
Van-der-waals ICL1 N 437 12x51 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 P 517 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 517 34x50 G.H5 I 370 G.H5.15
Aromatic ICL2 F 518 34x51 G.S3 F 223 G.S3.03
Hydrophobic ICL2 F 518 34x51 G.S3 F 223 G.S3.03
Hydrophobic TM5 S 605 5x64 G.H5 L 371 G.H5.16
Van-der-waals TM5 S 605 5x64 G.H5 L 371 G.H5.16
Hydrophobic ICL2 F 518 34x51 G.H5 V 366 G.H5.11
Polar TM5 T 612 5x71 G.H5 D 368 G.H5.13
Van-der-waals TM5 T 612 5x71 G.H5 D 368 G.H5.13
Hydrophobic TM6 L 626 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 L 626 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM3 I 514 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 514 3x54 G.H5 L 371 G.H5.16