G12 - RXFP2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.6
PAE mean: 17.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 T 623 5x72 G.H5 A 365 G.H5.10
Hydrophobic TM3 I 524 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 524 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL1 A 445 12x49 G.H5 Q 381 G.H5.26
Polar TM1 R 440 1x57 G.H5 Q 381 G.H5.26
Hydrophobic TM1 R 440 1x57 G.H5 Q 381 G.H5.26
Van-der-waals TM1 R 440 1x57 G.H5 Q 381 G.H5.26
Polar TM5 Q 622 5x71 G.H5 H 364 G.H5.09
Hydrophobic TM5 Q 622 5x71 G.H5 H 364 G.H5.09
Van-der-waals TM5 Q 622 5x71 G.H5 H 364 G.H5.09
Ionic ICL2 R 532 34x55 G.H5 D 377 G.H5.22
Polar ICL2 R 532 34x55 G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 532 34x55 G.H5 D 377 G.H5.22
Hydrophobic TM5 I 616 5x65 G.H5 L 371 G.H5.16
Hydrophobic TM5 T 623 5x72 G.H5 H 364 G.H5.09
Hydrophobic ICL2 F 528 34x51 G.S3 F 223 G.S3.03
Hydrophobic TM6 C 629 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 C 629 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 V 626 6x23 G.S6 L 346 G.S6.01
Van-der-waals TM6 V 626 6x23 G.S6 L 346 G.S6.01
Hydrophobic TM2 I 454 2x43 G.H5 Q 381 G.H5.26
Van-der-waals TM2 I 454 2x43 G.H5 Q 381 G.H5.26
Van-der-waals TM7 T 694 7x56 G.H5 M 379 G.H5.24
Hydrophobic H8 T 695 8x47 G.H5 Q 381 G.H5.26
Polar TM6 R 639 6x36 G.H5 Q 381 G.H5.26
Hydrophobic TM6 F 640 6x37 G.H5 L 375 G.H5.20
Van-der-waals TM6 F 640 6x37 G.H5 L 375 G.H5.20
Ionic ICL3 E 625 - G.S6 H 349 G.S6.04
Polar ICL3 E 625 - G.S6 H 349 G.S6.04
Polar TM3 V 523 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 V 523 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 V 523 3x53 G.H5 N 374 G.H5.19
Aromatic ICL2 F 528 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 528 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 528 34x51 G.H5 F 363 G.H5.08
Polar TM4 Q 537 4x41 G.HN R 52 G.HN.52
Van-der-waals TM4 Q 537 4x41 G.HN R 52 G.HN.52
Polar TM6 R 632 6x29 G.h4s6 S 343 G.h4s6.12
Polar ICL2 R 532 34x55 G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 532 34x55 G.H5 N 374 G.H5.19
Hydrophobic TM5 T 623 5x72 G.S6 F 347 G.S6.02
Hydrophobic H8 N 696 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 N 696 8x48 G.H5 L 380 G.H5.25
Hydrophobic TM5 T 619 5x68 G.H5 L 371 G.H5.16
Polar TM5 T 623 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM5 T 623 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 T 623 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM6 V 636 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 V 636 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM5 I 616 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM6 R 632 6x29 G.H5 K 376 G.H5.21
Polar TM5 T 619 5x68 G.H5 K 367 G.H5.12
Hydrophobic TM5 T 619 5x68 G.H5 K 367 G.H5.12
Van-der-waals TM5 T 619 5x68 G.H5 K 367 G.H5.12
Hydrophobic ICL2 F 528 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 528 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 N 530 34x53 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 I 524 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 524 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 F 528 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 528 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM6 V 626 6x23 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 V 626 6x23 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 F 528 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 F 528 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM5 T 619 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 T 619 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM6 V 636 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 636 6x33 G.H5 M 379 G.H5.24
Polar TM5 S 615 5x64 G.H5 K 367 G.H5.12
Hydrophobic TM3 V 523 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 523 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 527 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 527 34x50 G.H5 I 370 G.H5.15
Polar TM6 R 639 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM6 R 639 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 R 639 6x36 G.H5 M 379 G.H5.24
Polar ICL1 N 447 12x51 G.H5 Q 381 G.H5.26
Hydrophobic ICL1 N 447 12x51 G.H5 Q 381 G.H5.26
Van-der-waals ICL1 N 447 12x51 G.H5 Q 381 G.H5.26
Hydrophobic TM2 H 450 2x39 G.H5 Q 381 G.H5.26
Hydrophobic TM3 I 524 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 F 528 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 528 34x51 G.H5 I 370 G.H5.15
Hydrophobic H8 T 695 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 T 695 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 528 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM6 V 626 6x23 G.S6 F 347 G.S6.02
Van-der-waals TM6 V 626 6x23 G.S6 F 347 G.S6.02
Hydrophobic TM3 K 520 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 K 520 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 527 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL3 E 625 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 E 625 - G.S6 H 348 G.S6.03
Hydrophobic ICL2 P 527 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 527 34x50 G.H5 K 367 G.H5.12
Polar ICL2 N 530 34x53 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 N 530 34x53 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 N 530 34x53 G.hns1 R 55 G.hns1.02