G14 -
S1P4 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | C-term | S | 377 | - | G.s4h3 | L | 235 | G.s4h3.08 |
Van-der-waals | C-term | S | 377 | - | G.s4h3 | L | 235 | G.s4h3.08 |
Van-der-waals | C-term | L | 375 | - | G.s4h3 | D | 239 | G.s4h3.12 |
Polar | C-term | S | 377 | - | G.s4h3 | C | 238 | G.s4h3.11 |
Polar | C-term | S | 379 | - | G.s4h3 | A | 236 | G.s4h3.09 |
Hydrophobic | C-term | S | 379 | - | G.s4h3 | A | 236 | G.s4h3.09 |
Van-der-waals | C-term | S | 379 | - | G.s4h3 | A | 236 | G.s4h3.09 |
Hydrophobic | C-term | I | 378 | - | H.HA | T | 92 | H.HA.28 |
Hydrophobic | C-term | I | 378 | - | G.s4h3 | D | 239 | G.s4h3.12 |
Van-der-waals | C-term | I | 378 | - | G.s4h3 | D | 239 | G.s4h3.12 |
Polar | TM3 | R | 143 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 143 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 143 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | M | 147 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | M | 147 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | V | 151 | 34x51 | G.S3 | I | 195 | G.S3.01 |
Van-der-waals | ICL2 | V | 151 | 34x51 | G.S3 | I | 195 | G.S3.01 |
Hydrophobic | TM5 | L | 229 | 5x64 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | TM6 | R | 248 | 6x32 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM6 | R | 248 | 6x32 | G.H5 | V | 355 | G.H5.26 |
Polar | C-term | S | 379 | - | G.s4h3 | D | 239 | G.s4h3.12 |
Hydrophobic | C-term | S | 379 | - | G.s4h3 | D | 239 | G.s4h3.12 |
Van-der-waals | C-term | S | 379 | - | G.s4h3 | D | 239 | G.s4h3.12 |
Polar | TM6 | K | 245 | 6x29 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | TM6 | K | 245 | 6x29 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM6 | K | 245 | 6x29 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | TM5 | S | 233 | 5x68 | G.H5 | L | 345 | G.H5.16 |
Polar | H8 | S | 311 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | H8 | S | 311 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | H8 | S | 311 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Polar | TM5 | S | 233 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | S | 233 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | S | 233 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Polar | TM6 | L | 249 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | L | 249 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | L | 249 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Polar | C-term | S | 377 | - | G.s4h3 | D | 239 | G.s4h3.12 |
Hydrophobic | C-term | S | 377 | - | G.s4h3 | D | 239 | G.s4h3.12 |
Van-der-waals | C-term | S | 377 | - | G.s4h3 | D | 239 | G.s4h3.12 |
Aromatic | TM2 | W | 80 | 2x38 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM2 | W | 80 | 2x38 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM2 | W | 80 | 2x38 | G.H5 | F | 352 | G.H5.23 |
Polar | TM6 | T | 252 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | T | 252 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | T | 252 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | L | 375 | - | G.s4h3 | V | 234 | G.s4h3.07 |
Polar | ICL2 | A | 156 | 34x56 | G.HN | K | 30 | G.HN.52 |
Hydrophobic | ICL2 | A | 156 | 34x56 | G.HN | K | 30 | G.HN.52 |
Van-der-waals | ICL2 | A | 156 | 34x56 | G.HN | K | 30 | G.HN.52 |
Hydrophobic | TM3 | M | 147 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | M | 147 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM7 | R | 310 | 7x56 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM7 | R | 310 | 7x56 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | C-term | L | 375 | - | G.hgh4 | Y | 287 | G.hgh4.01 |
Polar | C-term | S | 377 | - | H.hdhe | Q | 148 | H.hdhe.02 |
Van-der-waals | C-term | S | 377 | - | H.hdhe | Q | 148 | H.hdhe.02 |
Polar | TM3 | T | 146 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | T | 146 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | T | 146 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | C-term | V | 381 | - | H.HA | T | 81 | H.HA.17 |
Polar | ICL2 | P | 150 | 34x50 | G.hns1 | R | 34 | G.hns1.03 |
Van-der-waals | ICL2 | P | 150 | 34x50 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | ICL2 | V | 151 | 34x51 | G.S1 | L | 36 | G.S1.02 |
Van-der-waals | ICL2 | V | 151 | 34x51 | G.S1 | L | 36 | G.S1.02 |
Polar | C-term | S | 379 | - | H.hdhe | Q | 148 | H.hdhe.02 |
Hydrophobic | C-term | S | 379 | - | H.hdhe | Q | 148 | H.hdhe.02 |
Van-der-waals | C-term | S | 379 | - | H.hdhe | Q | 148 | H.hdhe.02 |
Hydrophobic | TM6 | L | 249 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM2 | V | 81 | 2x39 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM2 | V | 81 | 2x39 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM5 | V | 230 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM5 | V | 230 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM6 | K | 245 | 6x29 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | TM3 | T | 146 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | T | 146 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Polar | C-term | S | 376 | - | H.HD | E | 146 | H.HD.12 |
Hydrophobic | C-term | S | 376 | - | H.HD | E | 146 | H.HD.12 |
Van-der-waals | C-term | S | 376 | - | H.HD | E | 146 | H.HD.12 |
Hydrophobic | ICL2 | V | 151 | 34x51 | G.hns1 | R | 34 | G.hns1.03 |
Van-der-waals | ICL2 | V | 151 | 34x51 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | ICL2 | P | 150 | 34x50 | G.H5 | K | 341 | G.H5.12 |
Van-der-waals | ICL2 | P | 150 | 34x50 | G.H5 | K | 341 | G.H5.12 |
Aromatic | TM6 | R | 239 | 6x23 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | TM6 | R | 239 | 6x23 | G.h4s6 | V | 319 | G.h4s6.20 |
Van-der-waals | TM6 | R | 239 | 6x23 | G.h4s6 | V | 319 | G.h4s6.20 |
Ionic | TM2 | R | 79 | 2x37 | G.H5 | E | 351 | G.H5.22 |
Polar | TM2 | R | 79 | 2x37 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | TM2 | R | 79 | 2x37 | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | TM2 | R | 79 | 2x37 | G.H5 | E | 351 | G.H5.22 |
Polar | C-term | I | 378 | - | H.hdhe | Q | 148 | H.hdhe.02 |
Hydrophobic | C-term | I | 378 | - | H.hdhe | Q | 148 | H.hdhe.02 |
Van-der-waals | C-term | I | 378 | - | H.hdhe | Q | 148 | H.hdhe.02 |
Hydrophobic | ICL2 | V | 151 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | V | 151 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | ICL2 | S | 154 | 34x54 | G.hns1 | A | 32 | G.hns1.01 |
Polar | ICL2 | S | 154 | 34x54 | G.HN | K | 30 | G.HN.52 |
Hydrophobic | ICL2 | S | 154 | 34x54 | G.HN | K | 30 | G.HN.52 |
Van-der-waals | ICL2 | S | 154 | 34x54 | G.HN | K | 30 | G.HN.52 |
Hydrophobic | TM3 | M | 147 | 3x54 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM5 | Y | 223 | 5x58 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | M | 147 | 3x54 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM3 | M | 147 | 3x54 | G.H5 | L | 345 | G.H5.16 |
Polar | TM6 | R | 239 | 6x23 | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | TM6 | R | 239 | 6x23 | G.S6 | I | 320 | G.S6.01 |
Van-der-waals | TM6 | R | 239 | 6x23 | G.S6 | I | 320 | G.S6.01 |
Polar | C-term | S | 377 | - | G.s4h3 | V | 234 | G.s4h3.07 |
Hydrophobic | C-term | S | 377 | - | G.s4h3 | V | 234 | G.s4h3.07 |
Van-der-waals | C-term | S | 377 | - | G.s4h3 | V | 234 | G.s4h3.07 |
Hydrophobic | C-term | S | 380 | - | H.hdhe | Q | 148 | H.hdhe.02 |
Van-der-waals | C-term | S | 380 | - | H.hdhe | Q | 148 | H.hdhe.02 |
Hydrophobic | TM3 | R | 143 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | M | 147 | 3x54 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | ICL2 | S | 154 | 34x54 | G.HN | D | 31 | G.HN.53 |
Hydrophobic | ICL2 | P | 150 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | P | 150 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Polar | C-term | S | 379 | - | G.s4h3 | L | 235 | G.s4h3.08 |
Hydrophobic | C-term | S | 379 | - | G.s4h3 | L | 235 | G.s4h3.08 |
Van-der-waals | C-term | S | 379 | - | G.s4h3 | L | 235 | G.s4h3.08 |
Hydrophobic | TM5 | V | 230 | 5x65 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | C-term | S | 376 | - | G.s4h3 | V | 234 | G.s4h3.07 |
Ionic | TM6 | R | 248 | 6x32 | G.h4s6 | E | 317 | G.h4s6.12 |