Go -
secretin receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 71.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM5 | T | 326 | 5x67 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM5 | T | 326 | 5x67 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | TM5 | T | 326 | 5x67 | G.hns1 | K | 32 | G.hns1.03 |
Polar | ICL2 | F | 249 | - | G.HN | K | 21 | G.HN.45 |
Aromatic | ICL2 | F | 249 | - | G.HN | K | 21 | G.HN.45 |
Hydrophobic | ICL2 | F | 249 | - | G.HN | K | 21 | G.HN.45 |
Van-der-waals | ICL2 | F | 249 | - | G.HN | K | 21 | G.HN.45 |
Polar | C-term | S | 422 | - | G.h3s5 | I | 261 | G.h3s5.01 |
Hydrophobic | C-term | S | 422 | - | G.h3s5 | I | 261 | G.h3s5.01 |
Van-der-waals | C-term | S | 422 | - | G.h3s5 | I | 261 | G.h3s5.01 |
Hydrophobic | TM3 | L | 244 | 3x58 | G.HN | I | 28 | G.HN.52 |
Polar | TM4 | E | 251 | 4x39 | G.HN | K | 17 | G.HN.41 |
Van-der-waals | TM4 | E | 251 | 4x39 | G.HN | K | 17 | G.HN.41 |
Polar | C-term | N | 421 | - | G.h4s6 | N | 312 | G.h4s6.02 |
Van-der-waals | C-term | N | 421 | - | G.h4s6 | N | 312 | G.h4s6.02 |
Hydrophobic | TM5 | K | 323 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | K | 323 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL3 | Q | 327 | - | G.H5 | I | 343 | G.H5.15 |
Polar | C-term | F | 419 | - | G.h4s6 | P | 315 | G.h4s6.09 |
Hydrophobic | C-term | F | 419 | - | G.h4s6 | P | 315 | G.h4s6.09 |
Van-der-waals | C-term | F | 419 | - | G.h4s6 | P | 315 | G.h4s6.09 |
Polar | ICL3 | E | 328 | - | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | ICL3 | E | 328 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL3 | E | 328 | - | G.S3 | L | 195 | G.S3.01 |
Polar | TM5 | T | 326 | 5x67 | G.S1 | D | 33 | G.S1.01 |
Hydrophobic | TM5 | T | 326 | 5x67 | G.S1 | D | 33 | G.S1.01 |
Van-der-waals | TM5 | T | 326 | 5x67 | G.S1 | D | 33 | G.S1.01 |
Polar | TM5 | K | 323 | 5x64 | G.HN | I | 28 | G.HN.52 |
Van-der-waals | TM5 | K | 323 | 5x64 | G.HN | I | 28 | G.HN.52 |
Polar | ICL2 | F | 248 | - | G.HN | K | 24 | G.HN.48 |
Hydrophobic | ICL2 | F | 248 | - | G.HN | K | 24 | G.HN.48 |
Van-der-waals | ICL2 | F | 248 | - | G.HN | K | 24 | G.HN.48 |
Polar | ICL3 | R | 330 | - | G.H1 | H | 57 | G.H1.12 |
Hydrophobic | ICL3 | R | 330 | - | G.H1 | H | 57 | G.H1.12 |
Van-der-waals | ICL3 | R | 330 | - | G.H1 | H | 57 | G.H1.12 |
Polar | C-term | T | 423 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | C-term | T | 423 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | T | 423 | - | G.H3 | K | 258 | G.H3.16 |
Polar | ICL3 | T | 329 | - | G.S3 | H | 196 | G.S3.02 |
Van-der-waals | ICL3 | T | 329 | - | G.S3 | H | 196 | G.S3.02 |
Hydrophobic | TM3 | L | 243 | 3x57 | G.HN | I | 28 | G.HN.52 |
Ionic | C-term | K | 424 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Polar | C-term | K | 424 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Van-der-waals | C-term | K | 424 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Hydrophobic | TM3 | L | 243 | 3x57 | G.HN | K | 21 | G.HN.45 |
Aromatic | ICL3 | R | 330 | - | G.S2 | F | 192 | G.S2.08 |
Hydrophobic | ICL3 | R | 330 | - | G.S2 | F | 192 | G.S2.08 |
Van-der-waals | ICL3 | R | 330 | - | G.S2 | F | 192 | G.S2.08 |
Polar | ICL3 | E | 328 | - | G.S3 | H | 196 | G.S3.02 |
Van-der-waals | ICL3 | E | 328 | - | G.S3 | H | 196 | G.S3.02 |
Polar | ICL1 | H | 171 | 12x51 | G.HN | K | 17 | G.HN.41 |
Hydrophobic | TM6 | S | 343 | 6x41 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | L | 243 | 3x57 | G.HN | K | 24 | G.HN.48 |
Polar | C-term | S | 420 | - | G.h4s6 | S | 314 | G.h4s6.08 |
Hydrophobic | C-term | S | 420 | - | G.h4s6 | S | 314 | G.h4s6.08 |
Van-der-waals | C-term | S | 420 | - | G.h4s6 | S | 314 | G.h4s6.08 |
Polar | ICL3 | R | 330 | - | G.S2 | T | 191 | G.S2.07 |
Hydrophobic | ICL3 | R | 330 | - | G.S2 | T | 191 | G.S2.07 |
Van-der-waals | ICL3 | R | 330 | - | G.S2 | T | 191 | G.S2.07 |
Polar | ICL3 | Q | 327 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL3 | Q | 327 | - | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL3 | Q | 327 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | F | 248 | - | G.HN | G | 27 | G.HN.51 |
Polar | TM4 | R | 252 | 4x40 | G.HN | K | 17 | G.HN.41 |
Hydrophobic | TM4 | R | 252 | 4x40 | G.HN | K | 17 | G.HN.41 |
Van-der-waals | TM4 | R | 252 | 4x40 | G.HN | K | 17 | G.HN.41 |
Polar | C-term | S | 420 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | S | 420 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | C-term | S | 420 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | N | 421 | - | G.h4s6 | S | 314 | G.h4s6.08 |
Van-der-waals | C-term | N | 421 | - | G.h4s6 | S | 314 | G.h4s6.08 |
Hydrophobic | TM5 | R | 325 | 5x66 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM3 | L | 240 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | L | 240 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL3 | E | 328 | - | G.S2 | F | 192 | G.S2.08 |
Hydrophobic | ICL3 | Q | 327 | - | G.s2s3 | N | 194 | G.s2s3.02 |
Van-der-waals | ICL3 | Q | 327 | - | G.s2s3 | N | 194 | G.s2s3.02 |
Polar | TM5 | L | 324 | 5x65 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM5 | L | 324 | 5x65 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | TM5 | L | 324 | 5x65 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | C-term | K | 424 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | K | 424 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | ICL2 | F | 248 | - | G.HN | K | 21 | G.HN.45 |
Hydrophobic | TM5 | I | 316 | 5x57 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM5 | I | 316 | 5x57 | G.H5 | L | 353 | G.H5.25 |
Polar | TM4 | S | 250 | 4x38 | G.HN | K | 21 | G.HN.45 |
Hydrophobic | TM4 | S | 250 | 4x38 | G.HN | K | 21 | G.HN.45 |
Van-der-waals | TM4 | S | 250 | 4x38 | G.HN | K | 21 | G.HN.45 |
Polar | TM4 | S | 250 | 4x38 | G.HN | N | 22 | G.HN.46 |
Hydrophobic | TM4 | S | 250 | 4x38 | G.HN | N | 22 | G.HN.46 |
Van-der-waals | TM4 | S | 250 | 4x38 | G.HN | N | 22 | G.HN.46 |
Hydrophobic | ICL3 | T | 329 | - | G.S2 | T | 191 | G.S2.07 |
Van-der-waals | ICL3 | T | 329 | - | G.S2 | T | 191 | G.S2.07 |
Hydrophobic | ICL2 | F | 248 | - | G.HN | S | 29 | G.HN.53 |
Van-der-waals | ICL2 | F | 248 | - | G.HN | S | 29 | G.HN.53 |
Polar | TM2 | T | 173 | 2x45 | G.HN | K | 17 | G.HN.41 |
Van-der-waals | TM2 | T | 173 | 2x45 | G.HN | K | 17 | G.HN.41 |
Polar | TM4 | S | 250 | 4x38 | G.HN | A | 18 | G.HN.42 |
Van-der-waals | TM4 | S | 250 | 4x38 | G.HN | A | 18 | G.HN.42 |
Hydrophobic | TM4 | E | 251 | 4x39 | G.HN | K | 21 | G.HN.45 |
Van-der-waals | TM4 | E | 251 | 4x39 | G.HN | K | 21 | G.HN.45 |
Polar | TM5 | K | 323 | 5x64 | G.HN | S | 29 | G.HN.53 |
Van-der-waals | TM5 | K | 323 | 5x64 | G.HN | S | 29 | G.HN.53 |
Polar | C-term | N | 421 | - | G.h4s6 | K | 317 | G.h4s6.11 |
Hydrophobic | C-term | N | 421 | - | G.h4s6 | K | 317 | G.h4s6.11 |
Van-der-waals | C-term | N | 421 | - | G.h4s6 | K | 317 | G.h4s6.11 |
Hydrophobic | TM5 | L | 324 | 5x65 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM5 | L | 324 | 5x65 | G.H5 | Y | 354 | G.H5.26 |
Polar | C-term | F | 419 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | F | 419 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | C-term | F | 419 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | S | 422 | - | G.h4s6 | K | 317 | G.h4s6.11 |
Hydrophobic | C-term | F | 419 | - | G.h4s6 | S | 314 | G.h4s6.08 |
Hydrophobic | ICL2 | F | 248 | - | G.HN | E | 25 | G.HN.49 |
Van-der-waals | ICL2 | F | 248 | - | G.HN | E | 25 | G.HN.49 |
Hydrophobic | TM5 | L | 320 | 5x61 | G.H5 | Y | 354 | G.H5.26 |
Polar | ICL2 | S | 247 | - | G.HN | I | 28 | G.HN.52 |
Hydrophobic | ICL2 | S | 247 | - | G.HN | I | 28 | G.HN.52 |
Van-der-waals | ICL2 | S | 247 | - | G.HN | I | 28 | G.HN.52 |
Polar | TM6 | R | 339 | 6x37 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | R | 339 | 6x37 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 339 | 6x37 | G.H5 | Y | 354 | G.H5.26 |
Polar | TM4 | R | 252 | 4x40 | G.HN | L | 13 | G.HN.37 |
Hydrophobic | TM4 | R | 252 | 4x40 | G.HN | L | 13 | G.HN.37 |
Van-der-waals | TM4 | R | 252 | 4x40 | G.HN | L | 13 | G.HN.37 |
Hydrophobic | C-term | A | 425 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | A | 425 | - | G.H3 | K | 258 | G.H3.16 |
Polar | ICL2 | F | 249 | - | G.HN | E | 25 | G.HN.49 |
Hydrophobic | ICL2 | F | 249 | - | G.HN | E | 25 | G.HN.49 |
Van-der-waals | ICL2 | F | 249 | - | G.HN | E | 25 | G.HN.49 |
Polar | ICL3 | E | 328 | - | G.s2s3 | N | 194 | G.s2s3.02 |
Hydrophobic | ICL3 | E | 328 | - | G.s2s3 | N | 194 | G.s2s3.02 |
Van-der-waals | ICL3 | E | 328 | - | G.s2s3 | N | 194 | G.s2s3.02 |
Polar | TM4 | S | 250 | 4x38 | G.HN | E | 25 | G.HN.49 |
Van-der-waals | TM4 | S | 250 | 4x38 | G.HN | E | 25 | G.HN.49 |
Polar | ICL3 | Q | 327 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | ICL3 | Q | 327 | - | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL3 | Q | 327 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM3 | L | 240 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Polar | C-term | S | 420 | - | G.h4s6 | K | 317 | G.h4s6.11 |
Hydrophobic | C-term | S | 420 | - | G.h4s6 | K | 317 | G.h4s6.11 |
Van-der-waals | C-term | S | 420 | - | G.h4s6 | K | 317 | G.h4s6.11 |
Ionic | TM4 | E | 251 | 4x39 | G.HN | K | 24 | G.HN.48 |
Polar | TM4 | E | 251 | 4x39 | G.HN | K | 24 | G.HN.48 |
Van-der-waals | TM4 | E | 251 | 4x39 | G.HN | K | 24 | G.HN.48 |
Hydrophobic | TM5 | K | 323 | 5x64 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | TM5 | K | 323 | 5x64 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM3 | L | 243 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | L | 243 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | A | 425 | - | G.H3 | F | 259 | G.H3.17 |
Van-der-waals | C-term | A | 425 | - | G.H3 | F | 259 | G.H3.17 |
Hydrophobic | TM3 | L | 244 | 3x58 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | C-term | N | 421 | - | G.h4s6 | R | 313 | G.h4s6.03 |
Van-der-waals | C-term | N | 421 | - | G.h4s6 | R | 313 | G.h4s6.03 |
Polar | TM2 | R | 174 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | R | 174 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Polar | C-term | S | 420 | - | G.h4s6 | P | 315 | G.h4s6.09 |
Hydrophobic | C-term | S | 420 | - | G.h4s6 | P | 315 | G.h4s6.09 |
Van-der-waals | C-term | S | 420 | - | G.h4s6 | P | 315 | G.h4s6.09 |
Polar | C-term | S | 420 | - | G.h4s6 | N | 312 | G.h4s6.02 |
Hydrophobic | C-term | S | 420 | - | G.h4s6 | N | 312 | G.h4s6.02 |
Van-der-waals | C-term | S | 420 | - | G.h4s6 | N | 312 | G.h4s6.02 |
Hydrophobic | TM5 | K | 323 | 5x64 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM5 | K | 323 | 5x64 | G.H5 | N | 347 | G.H5.19 |
Polar | TM5 | K | 323 | 5x64 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM5 | K | 323 | 5x64 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | TM5 | K | 323 | 5x64 | G.hns1 | A | 31 | G.hns1.02 |
Ionic | TM4 | R | 252 | 4x40 | G.HN | E | 14 | G.HN.38 |
Hydrophobic | TM4 | R | 252 | 4x40 | G.HN | E | 14 | G.HN.38 |
Van-der-waals | TM4 | R | 252 | 4x40 | G.HN | E | 14 | G.HN.38 |
Polar | C-term | S | 418 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | S | 418 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | C-term | S | 418 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | C-term | S | 420 | - | G.h4s6 | R | 313 | G.h4s6.03 |
Hydrophobic | C-term | S | 420 | - | G.h4s6 | R | 313 | G.h4s6.03 |
Van-der-waals | C-term | S | 420 | - | G.h4s6 | R | 313 | G.h4s6.03 |
Hydrophobic | TM3 | L | 244 | 3x58 | G.H5 | C | 351 | G.H5.23 |
Polar | ICL3 | Q | 327 | - | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | ICL3 | Q | 327 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL3 | Q | 327 | - | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | C-term | K | 424 | - | G.h3s5 | I | 261 | G.h3s5.01 |
Van-der-waals | C-term | K | 424 | - | G.h3s5 | I | 261 | G.h3s5.01 |
Polar | ICL3 | Q | 327 | - | G.S1 | D | 33 | G.S1.01 |
Hydrophobic | ICL3 | Q | 327 | - | G.S1 | D | 33 | G.S1.01 |
Van-der-waals | ICL3 | Q | 327 | - | G.S1 | D | 33 | G.S1.01 |
Polar | ICL2 | S | 247 | - | G.HN | S | 29 | G.HN.53 |
Hydrophobic | ICL2 | S | 247 | - | G.HN | S | 29 | G.HN.53 |
Van-der-waals | ICL2 | S | 247 | - | G.HN | S | 29 | G.HN.53 |
Polar | ICL3 | E | 328 | - | G.S1 | D | 33 | G.S1.01 |
Hydrophobic | C-term | N | 421 | - | G.h4s6 | P | 315 | G.h4s6.09 |
Van-der-waals | C-term | N | 421 | - | G.h4s6 | P | 315 | G.h4s6.09 |
Hydrophobic | ICL3 | E | 328 | - | G.S2 | T | 191 | G.S2.07 |
Van-der-waals | ICL3 | E | 328 | - | G.S2 | T | 191 | G.S2.07 |
Hydrophobic | C-term | T | 423 | - | G.h3s5 | I | 261 | G.h3s5.01 |
Van-der-waals | C-term | T | 423 | - | G.h3s5 | I | 261 | G.h3s5.01 |
Hydrophobic | TM5 | L | 320 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM5 | L | 320 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | L | 244 | 3x58 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | L | 244 | 3x58 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | Q | 327 | - | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL3 | Q | 327 | - | G.H5 | I | 344 | G.H5.16 |