G12 - SMO complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 69.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 20.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 L 267 2x44 G.H5 L 380 G.H5.25
Van-der-waals TM2 L 267 2x44 G.H5 L 380 G.H5.25
Hydrophobic TM3 F 343 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 F 343 3x54 G.H5 I 378 G.H5.23
Polar TM3 A 345 3x56 G.H5 N 374 G.H5.19
Hydrophobic ICL3 L 436 - G.H5 K 367 G.H5.12
Polar C-term D 784 - G.H2 Q 234 G.H2.03
Van-der-waals C-term D 784 - G.H2 Q 234 G.H2.03
Polar ICL2 L 346 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 346 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 L 346 - G.H5 N 374 G.H5.19
Hydrophobic C-term P 645 - G.h1ha G 82 G.h1ha.01
Van-der-waals C-term P 645 - G.h1ha G 82 G.h1ha.01
Polar C-term M 776 - H.HA D 110 H.HA.24
Hydrophobic C-term M 776 - H.HA D 110 H.HA.24
Van-der-waals C-term M 776 - H.HA D 110 H.HA.24
Polar ICL2 T 349 - G.hns1 R 56 G.hns1.03
Hydrophobic C-term L 775 - H.HA A 111 H.HA.25
Van-der-waals C-term L 775 - H.HA A 111 H.HA.25
Polar ICL2 Y 350 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 Y 350 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 Y 350 - G.hns1 R 55 G.hns1.02
Polar C-term A 643 - G.h1ha R 83 G.h1ha.02
Hydrophobic C-term A 643 - G.h1ha R 83 G.h1ha.02
Van-der-waals C-term A 643 - G.h1ha R 83 G.h1ha.02
Polar C-term T 773 - H.HA K 114 H.HA.28
Hydrophobic C-term T 773 - H.HA K 114 H.HA.28
Van-der-waals C-term T 773 - H.HA K 114 H.HA.28
Hydrophobic ICL3 L 437 - G.H5 H 364 G.H5.09
Hydrophobic ICL2 T 349 - G.H5 I 370 G.H5.15
Hydrophobic TM6 I 445 6x26 G.H5 L 371 G.H5.16
Polar TM6 S 438 6x19 G.H5 D 368 G.H5.13
Hydrophobic TM6 S 438 6x19 G.H5 D 368 G.H5.13
Van-der-waals TM6 S 438 6x19 G.H5 D 368 G.H5.13
Hydrophobic C-term V 600 - G.H3 E 278 G.H3.10
Polar TM6 K 444 6x25 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 444 6x25 G.H5 Q 381 G.H5.26
Aromatic C-term R 562 - G.h3s5 F 287 G.h3s5.01
Hydrophobic C-term R 562 - G.h3s5 F 287 G.h3s5.01
Van-der-waals C-term R 562 - G.h3s5 F 287 G.h3s5.01
Hydrophobic ICL2 L 346 - G.H5 L 375 G.H5.20
Polar TM2 R 261 2x38 G.H5 K 376 G.H5.21
Van-der-waals TM2 R 261 2x38 G.H5 K 376 G.H5.21
Ionic TM2 R 261 2x38 G.H5 D 377 G.H5.22
Polar TM2 R 261 2x38 G.H5 D 377 G.H5.22
Hydrophobic TM2 R 261 2x38 G.H5 D 377 G.H5.22
Van-der-waals TM2 R 261 2x38 G.H5 D 377 G.H5.22
Hydrophobic C-term L 775 - H.HA D 110 H.HA.24
Polar C-term N 774 - H.HA K 114 H.HA.28
Hydrophobic C-term N 774 - H.HA K 114 H.HA.28
Van-der-waals C-term N 774 - H.HA K 114 H.HA.28
Hydrophobic C-term L 780 - H.HA V 107 H.HA.21
Van-der-waals C-term L 780 - H.HA V 107 H.HA.21
Hydrophobic H8 A 540 8x49 G.H5 Q 381 G.H5.26
Hydrophobic C-term L 775 - H.HA K 114 H.HA.28
Van-der-waals C-term L 775 - H.HA K 114 H.HA.28
Polar ICL3 G 435 - G.H5 H 364 G.H5.09
Hydrophobic ICL3 G 435 - G.H5 H 364 G.H5.09
Van-der-waals ICL3 G 435 - G.H5 H 364 G.H5.09
Polar ICL2 Q 351 - G.hns1 R 55 G.hns1.02
Polar ICL2 T 349 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 T 349 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 T 349 - G.hns1 R 55 G.hns1.02
Ionic C-term D 784 - G.hfs2 K 209 G.hfs2.06
Polar C-term D 784 - G.hfs2 K 209 G.hfs2.06
Hydrophobic C-term D 784 - G.hfs2 K 209 G.hfs2.06
Van-der-waals C-term D 784 - G.hfs2 K 209 G.hfs2.06
Hydrophobic C-term R 562 - G.H3 K 284 G.H3.16
Ionic C-term D 782 - G.hfs2 K 209 G.hfs2.06
Polar C-term D 782 - G.hfs2 K 209 G.hfs2.06
Hydrophobic C-term D 782 - G.hfs2 K 209 G.hfs2.06
Van-der-waals C-term D 782 - G.hfs2 K 209 G.hfs2.06
Hydrophobic TM1 F 252 1x54 G.H5 L 380 G.H5.25
Van-der-waals TM1 F 252 1x54 G.H5 L 380 G.H5.25
Hydrophobic ICL3 L 436 - G.H5 H 364 G.H5.09
Van-der-waals ICL3 L 436 - G.H5 H 364 G.H5.09
Polar C-term L 654 - G.H5 R 360 G.H5.05
Hydrophobic C-term L 654 - G.H5 R 360 G.H5.05
Van-der-waals C-term L 654 - G.H5 R 360 G.H5.05
Polar TM6 E 447 6x28 G.H5 Q 381 G.H5.26
Hydrophobic TM6 E 447 6x28 G.H5 Q 381 G.H5.26
Van-der-waals TM6 E 447 6x28 G.H5 Q 381 G.H5.26
Polar C-term T 644 - G.h1ha R 83 G.h1ha.02
Hydrophobic C-term T 644 - G.h1ha R 83 G.h1ha.02
Van-der-waals C-term T 644 - G.h1ha R 83 G.h1ha.02
Hydrophobic ICL2 G 347 - G.H5 L 371 G.H5.16
Polar C-term W 655 - G.H5 E 357 G.H5.02
Hydrophobic C-term W 655 - G.H5 E 357 G.H5.02
Van-der-waals C-term W 655 - G.H5 E 357 G.H5.02
Hydrophobic C-term M 776 - H.HA K 114 H.HA.28
Van-der-waals C-term M 776 - H.HA K 114 H.HA.28
Hydrophobic TM2 A 264 2x41 G.H5 L 380 G.H5.25
Van-der-waals TM2 A 264 2x41 G.H5 L 380 G.H5.25
Polar TM3 W 339 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 W 339 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 W 339 3x50 G.H5 I 378 G.H5.23
Hydrophobic C-term V 657 - G.H5 F 361 G.H5.06
Van-der-waals C-term V 657 - G.H5 F 361 G.H5.06
Hydrophobic TM3 S 342 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 S 342 3x53 G.H5 I 378 G.H5.23
Polar C-term D 784 - G.s3h2 Q 231 G.s3h2.03
Hydrophobic C-term D 784 - G.s3h2 Q 231 G.s3h2.03
Van-der-waals C-term D 784 - G.s3h2 Q 231 G.s3h2.03
Hydrophobic TM6 T 448 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 448 6x29 G.H5 M 379 G.H5.24
Hydrophobic ICL2 T 348 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 T 348 - G.H5 I 370 G.H5.15
Polar ICL2 T 349 - G.S1 L 57 G.S1.01
Polar ICL2 T 348 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 T 348 - G.H5 N 374 G.H5.19
Hydrophobic C-term L 780 - H.HA K 103 H.HA.17
Van-der-waals C-term L 780 - H.HA K 103 H.HA.17
Polar TM5 H 433 5x76 G.H5 K 367 G.H5.12
Aromatic TM5 H 433 5x76 G.H5 K 367 G.H5.12
Hydrophobic TM5 H 433 5x76 G.H5 K 367 G.H5.12
Van-der-waals TM5 H 433 5x76 G.H5 K 367 G.H5.12
Hydrophobic C-term M 776 - H.HB M 132 H.HB.10
Van-der-waals C-term M 776 - H.HB M 132 H.HB.10
Aromatic ICL2 Y 350 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 Y 350 - G.hns1 R 56 G.hns1.03
Ionic C-term E 660 - G.S6 H 348 G.S6.03
Polar H8 T 538 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM6 I 445 6x26 G.H5 L 375 G.H5.20
Hydrophobic TM6 A 441 6x22 G.H5 D 368 G.H5.13
Van-der-waals TM6 A 441 6x22 G.H5 D 368 G.H5.13
Polar ICL2 S 354 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 S 354 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 S 354 - G.hns1 R 55 G.hns1.02
Hydrophobic TM6 K 444 6x25 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 444 6x25 G.H5 M 379 G.H5.24
Polar C-term W 655 - G.H5 R 360 G.H5.05
Hydrophobic C-term W 655 - G.H5 R 360 G.H5.05
Van-der-waals C-term W 655 - G.H5 R 360 G.H5.05
Hydrophobic ICL3 L 437 - G.H5 L 371 G.H5.16
Ionic C-term D 777 - G.s4h3 R 265 G.s4h3.12
Polar C-term D 777 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term D 777 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term D 777 - G.s4h3 R 265 G.s4h3.12
Ionic C-term E 650 - G.s2s3 K 220 G.s2s3.02
Polar C-term E 650 - G.s2s3 K 220 G.s2s3.02
Hydrophobic C-term E 650 - G.s2s3 K 220 G.s2s3.02
Van-der-waals C-term E 650 - G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 L 346 - G.H5 L 371 G.H5.16
Hydrophobic C-term T 778 - H.HB M 132 H.HB.10
Hydrophobic TM6 A 441 6x22 G.H5 L 371 G.H5.16
Van-der-waals TM6 A 441 6x22 G.H5 L 371 G.H5.16
Hydrophobic C-term V 657 - G.H5 H 364 G.H5.09
Van-der-waals C-term V 657 - G.H5 H 364 G.H5.09
Hydrophobic ICL2 G 347 - G.H5 I 370 G.H5.15
Polar C-term N 653 - G.H5 R 360 G.H5.05
Hydrophobic C-term N 653 - G.H5 R 360 G.H5.05
Van-der-waals C-term N 653 - G.H5 R 360 G.H5.05
Hydrophobic ICL2 T 349 - G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 L 346 - G.H5 I 378 G.H5.23
Van-der-waals ICL2 L 346 - G.H5 I 378 G.H5.23
Hydrophobic ICL3 L 436 - G.H5 F 363 G.H5.08
Hydrophobic C-term V 639 - G.HN R 6 G.HN.06
Hydrophobic TM5 I 429 5x72 G.H5 L 371 G.H5.16
Hydrophobic TM6 K 444 6x25 G.H5 L 375 G.H5.20
Hydrophobic C-term P 645 - G.h1ha R 83 G.h1ha.02
Van-der-waals C-term P 645 - G.h1ha R 83 G.h1ha.02
Van-der-waals C-term F 787 - G.H2 Q 236 G.H2.05