Gi1 -
SST1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 11.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL1 | A | 87 | 12x48 | G.HN | D | 20 | G.HN.44 |
Van-der-waals | ICL1 | A | 87 | 12x48 | G.HN | D | 20 | G.HN.44 |
Polar | C-term | Y | 354 | - | G.H2 | R | 205 | G.H2.01 |
Hydrophobic | TM3 | V | 159 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Polar | ICL2 | P | 162 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | P | 162 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | R | 167 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | R | 167 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | P | 162 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | I | 163 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Polar | ICL2 | R | 169 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | R | 169 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | ICL2 | R | 169 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Polar | TM6 | K | 268 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 268 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 268 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Ionic | C-term | E | 349 | - | G.H3 | K | 257 | G.H3.16 |
Polar | C-term | E | 349 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | E | 349 | - | G.H3 | K | 257 | G.H3.16 |
Polar | C-term | Y | 353 | - | G.H3 | N | 256 | G.H3.15 |
Hydrophobic | C-term | Y | 353 | - | G.H3 | N | 256 | G.H3.15 |
Van-der-waals | C-term | Y | 353 | - | G.H3 | N | 256 | G.H3.15 |
Hydrophobic | C-term | Y | 353 | - | G.H3 | I | 253 | G.H3.12 |
Polar | TM3 | D | 154 | 3x49 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | A | 166 | 34x54 | G.S3 | L | 194 | G.S3.01 |
Polar | TM4 | P | 171 | 4x39 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM4 | P | 171 | 4x39 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | P | 171 | 4x39 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM6 | M | 272 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | M | 272 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM5 | V | 253 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM4 | R | 170 | 4x38 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | TM4 | R | 170 | 4x38 | G.hns1 | R | 32 | G.hns1.03 |
Aromatic | C-term | Y | 353 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | C-term | Y | 353 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Van-der-waals | C-term | Y | 353 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Polar | ICL2 | A | 166 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | A | 166 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM5 | M | 250 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | M | 250 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Ionic | ICL3 | R | 262 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | ICL3 | R | 262 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | R | 262 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | R | 262 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | R | 262 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | R | 262 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | H8 | S | 327 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Polar | TM3 | A | 158 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 158 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 158 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Ionic | ICL2 | R | 169 | 34x57 | G.H5 | D | 350 | G.H5.22 |
Polar | ICL2 | R | 169 | 34x57 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL2 | R | 169 | 34x57 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | ICL2 | R | 169 | 34x57 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM3 | V | 159 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 159 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | I | 269 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM6 | I | 269 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | F | 379 | - | H.hbhc | E | 116 | H.hbhc.04 |
Van-der-waals | C-term | F | 379 | - | H.hbhc | E | 116 | H.hbhc.04 |
Ionic | ICL3 | R | 262 | - | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | R | 262 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | R | 262 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | R | 262 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | S | 265 | - | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | ICL3 | S | 265 | - | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | V | 351 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | TM6 | I | 269 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | I | 269 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | M | 272 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 272 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | K | 249 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | V | 273 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | V | 273 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | A | 166 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | A | 166 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | V | 351 | - | G.H3 | W | 258 | G.H3.17 |
Hydrophobic | ICL2 | I | 163 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | I | 163 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | C-term | Y | 354 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | TM3 | A | 158 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | A | 158 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Ionic | H8 | R | 332 | 8x52 | G.h3s5 | D | 261 | G.h3s5.02 |
Polar | TM2 | T | 93 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | T | 93 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | Y | 353 | - | G.H3 | F | 259 | G.H3.18 |
Van-der-waals | C-term | Y | 353 | - | G.H3 | F | 259 | G.H3.18 |
Ionic | TM4 | R | 170 | 4x38 | G.HN | E | 28 | G.HN.52 |
Polar | TM4 | R | 170 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | R | 170 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM5 | M | 250 | 5x65 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM3 | R | 155 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 155 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | V | 351 | - | G.H3 | N | 256 | G.H3.15 |
Van-der-waals | C-term | V | 351 | - | G.H3 | N | 256 | G.H3.15 |
Ionic | TM5 | K | 256 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Polar | TM5 | K | 256 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | ICL2 | P | 162 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM5 | V | 253 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | V | 253 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | TM3 | R | 155 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 155 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 155 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Ionic | ICL3 | R | 264 | - | G.h4s6 | D | 315 | G.h4s6.09 |
Polar | ICL3 | R | 264 | - | G.h4s6 | D | 315 | G.h4s6.09 |
Van-der-waals | ICL3 | R | 264 | - | G.h4s6 | D | 315 | G.h4s6.09 |
Ionic | ICL1 | K | 90 | 12x51 | G.HN | D | 20 | G.HN.44 |
Polar | ICL1 | K | 90 | 12x51 | G.HN | D | 20 | G.HN.44 |
Van-der-waals | ICL1 | K | 90 | 12x51 | G.HN | D | 20 | G.HN.44 |
Polar | C-term | Y | 354 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | C-term | Y | 354 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | ICL2 | P | 162 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 162 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM4 | T | 172 | 4x40 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | T | 172 | 4x40 | G.HN | R | 24 | G.HN.48 |
Polar | TM4 | T | 172 | 4x40 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM6 | I | 269 | 6x33 | G.H5 | F | 354 | G.H5.26 |