Gz - SST1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 R 155 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 R 155 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM6 V 273 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM5 K 249 5x64 G.H5 I 345 G.H5.16
Hydrophobic C-term K 359 - G.h2s4 G 218 G.h2s4.03
Van-der-waals C-term K 359 - G.h2s4 G 218 G.h2s4.03
Hydrophobic C-term S 386 - G.s4h3 Q 240 G.s4h3.13
Van-der-waals C-term S 386 - G.s4h3 Q 240 G.s4h3.13
Hydrophobic C-term L 358 - G.H5 I 344 G.H5.15
Hydrophobic C-term F 368 - G.H2 I 213 G.H2.08
Van-der-waals C-term F 368 - G.H2 I 213 G.H2.08
Hydrophobic TM3 A 158 3x53 G.H5 I 352 G.H5.23
Hydrophobic ICL3 W 259 - G.S6 Y 321 G.S6.02
Polar C-term T 356 - G.hns1 R 31 G.hns1.02
Hydrophobic TM5 K 256 5x71 G.H5 D 338 G.H5.09
Hydrophobic ICL2 P 162 34x50 G.H5 T 341 G.H5.12
Polar H8 N 329 8x49 G.H5 Y 351 G.H5.22
Polar C-term E 349 - G.h3s5 N 262 G.h3s5.02
Hydrophobic C-term V 365 - G.H2 I 213 G.H2.08
Polar C-term Y 353 - G.H5 Y 351 G.H5.22
Aromatic C-term Y 353 - G.H5 Y 351 G.H5.22
Hydrophobic C-term Y 353 - G.H5 Y 351 G.H5.22
Van-der-waals C-term Y 353 - G.H5 Y 351 G.H5.22
Hydrophobic C-term L 373 - G.H3 L 250 G.H3.08
Hydrophobic C-term S 364 - G.H3 W 259 G.H3.17
Van-der-waals C-term S 364 - G.H3 W 259 G.H3.17
Polar ICL3 R 262 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 R 262 - G.S6 Y 321 G.S6.02
Polar TM4 R 170 4x38 G.HN Q 28 G.HN.52
Hydrophobic TM4 R 170 4x38 G.HN Q 28 G.HN.52
Van-der-waals TM4 R 170 4x38 G.HN Q 28 G.HN.52
Hydrophobic C-term I 388 - G.s4h3 Q 240 G.s4h3.13
Polar C-term A 355 - G.H5 Y 351 G.H5.22
Hydrophobic C-term A 355 - G.H5 Y 351 G.H5.22
Van-der-waals C-term A 355 - G.H5 Y 351 G.H5.22
Hydrophobic C-term L 373 - G.H3 I 254 G.H3.12
Hydrophobic H8 S 327 8x47 G.H5 G 353 G.H5.24
Hydrophobic TM6 I 269 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 I 269 6x33 G.H5 L 349 G.H5.20
Hydrophobic ICL2 P 162 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 162 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM5 A 257 5x72 G.S6 H 323 G.S6.04
Hydrophobic TM2 T 93 2x39 G.H5 I 352 G.H5.23
Van-der-waals TM6 K 268 6x32 G.H5 C 355 G.H5.26
Hydrophobic ICL2 I 163 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 I 163 34x51 G.S3 L 195 G.S3.01
Polar C-term C 384 - G.s4h3 S 242 G.s4h3.15
Hydrophobic C-term C 384 - G.s4h3 S 242 G.s4h3.15
Van-der-waals C-term C 384 - G.s4h3 S 242 G.s4h3.15
Hydrophobic ICL2 I 163 34x51 G.s2s3 E 194 G.s2s3.02
Polar H8 N 329 8x49 G.H5 K 350 G.H5.21
Van-der-waals H8 N 329 8x49 G.H5 K 350 G.H5.21
Aromatic C-term Y 363 - G.H3 W 259 G.H3.17
Hydrophobic C-term Y 363 - G.H3 W 259 G.H3.17
Van-der-waals C-term Y 363 - G.H3 W 259 G.H3.17
Hydrophobic TM6 I 269 6x33 G.H5 C 355 G.H5.26
Van-der-waals TM6 I 269 6x33 G.H5 C 355 G.H5.26
Hydrophobic C-term V 365 - G.H3 W 259 G.H3.17
Polar ICL3 W 259 - G.S6 I 320 G.S6.01
Hydrophobic ICL3 W 259 - G.S6 I 320 G.S6.01
Van-der-waals ICL3 W 259 - G.S6 I 320 G.S6.01
Van-der-waals C-term L 358 - G.H5 N 347 G.H5.18
Hydrophobic TM5 A 257 5x72 G.S6 Y 321 G.S6.02
Van-der-waals TM5 A 257 5x72 G.S6 Y 321 G.S6.02
Ionic C-term K 359 - G.h2s4 E 217 G.h2s4.02
Polar C-term K 359 - G.h2s4 E 217 G.h2s4.02
Polar C-term D 352 - G.H5 Y 351 G.H5.22
Hydrophobic C-term T 383 - G.hgh4 P 289 G.hgh4.03
Hydrophobic TM6 M 272 6x36 G.H5 G 353 G.H5.24
Van-der-waals TM6 M 272 6x36 G.H5 G 353 G.H5.24
Van-der-waals C-term F 379 - G.h4s6 R 313 G.h4s6.03
Hydrophobic C-term F 379 - G.h4s6 L 311 G.h4s6.01
Hydrophobic C-term G 382 - G.hgh4 E 290 G.hgh4.04
Hydrophobic TM5 V 253 5x68 G.H5 I 345 G.H5.16
Polar C-term C 384 - G.HG I 286 G.HG.17
Hydrophobic ICL3 W 259 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 W 259 - G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 V 159 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 159 3x54 G.H5 L 349 G.H5.20
Polar C-term T 356 - G.H5 Y 351 G.H5.22
Hydrophobic C-term T 356 - G.H5 Y 351 G.H5.22
Van-der-waals C-term T 356 - G.H5 Y 351 G.H5.22
Hydrophobic TM3 V 159 3x54 G.H5 I 345 G.H5.16
Van-der-waals TM3 V 159 3x54 G.H5 I 345 G.H5.16
Polar TM3 A 158 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 158 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 158 3x53 G.H5 N 348 G.H5.19
Polar C-term Y 354 - G.hns1 R 31 G.hns1.02
Hydrophobic C-term Y 354 - G.hns1 R 31 G.hns1.02
Van-der-waals C-term Y 354 - G.hns1 R 31 G.hns1.02
Polar C-term S 360 - G.h2s4 G 218 G.h2s4.03
Hydrophobic C-term S 360 - G.h2s4 G 218 G.h2s4.03
Van-der-waals C-term S 360 - G.h2s4 G 218 G.h2s4.03
Aromatic C-term F 368 - G.h2s4 F 216 G.h2s4.01
Hydrophobic C-term F 368 - G.h2s4 F 216 G.h2s4.01
Van-der-waals C-term F 368 - G.h2s4 F 216 G.h2s4.01
Hydrophobic TM6 M 272 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 M 272 6x36 G.H5 L 354 G.H5.25
Polar C-term Y 354 - G.HN S 27 G.HN.51
Ionic ICL2 K 164 34x52 G.s2s3 E 194 G.s2s3.02
Polar ICL2 K 164 34x52 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 K 164 34x52 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 K 164 34x52 G.s2s3 E 194 G.s2s3.02
Polar C-term S 360 - G.h2s4 F 216 G.h2s4.01
Van-der-waals C-term S 360 - G.h2s4 F 216 G.h2s4.01
Polar ICL2 P 162 34x50 G.H5 N 348 G.H5.19
Polar C-term C 384 - G.hgh4 C 287 G.hgh4.01
Hydrophobic C-term C 384 - G.hgh4 C 287 G.hgh4.01
Van-der-waals C-term C 384 - G.hgh4 C 287 G.hgh4.01
Hydrophobic TM3 V 159 3x54 G.H5 I 352 G.H5.23
Polar C-term L 373 - G.H3 S 253 G.H3.11
Hydrophobic C-term L 373 - G.H3 S 253 G.H3.11
Van-der-waals C-term L 373 - G.H3 S 253 G.H3.11
Hydrophobic C-term A 357 - G.hns1 R 31 G.hns1.02
Polar C-term L 358 - G.h2s4 V 219 G.h2s4.04
Van-der-waals C-term L 358 - G.h2s4 V 219 G.h2s4.04
Polar C-term N 372 - G.H3 S 253 G.H3.11
Hydrophobic C-term L 358 - G.S1 I 34 G.S1.02
Van-der-waals C-term L 358 - G.S1 I 34 G.S1.02
Hydrophobic TM5 A 257 5x72 G.H5 D 342 G.H5.13
Hydrophobic C-term F 368 - G.H3 N 257 G.H3.15
Van-der-waals C-term F 368 - G.H3 N 257 G.H3.15
Hydrophobic ICL3 R 262 - G.H5 Q 346 G.H5.17
Van-der-waals ICL3 R 262 - G.H5 Q 346 G.H5.17
Hydrophobic C-term F 379 - G.H3 D 252 G.H3.10
Van-der-waals C-term F 379 - G.H3 D 252 G.H3.10
Hydrophobic C-term C 384 - G.hgh4 P 289 G.hgh4.03
Hydrophobic ICL2 I 163 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 I 163 34x51 G.H5 F 337 G.H5.08
Hydrophobic TM3 R 155 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 155 3x50 G.H5 L 354 G.H5.25
Polar C-term S 360 - G.h2s4 V 219 G.h2s4.04
Van-der-waals C-term S 360 - G.h2s4 V 219 G.h2s4.04
Polar C-term Y 353 - G.hns1 R 31 G.hns1.02
Hydrophobic TM5 M 250 5x65 G.H5 L 349 G.H5.20
Ionic ICL3 R 262 - G.h4s6 E 319 G.h4s6.12
Polar ICL3 R 262 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 R 262 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 R 262 - G.h4s6 E 319 G.h4s6.12
Polar ICL3 S 265 - G.H5 Q 346 G.H5.17
Hydrophobic C-term C 384 - G.H3 A 245 G.H3.03
Hydrophobic TM5 V 253 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 V 253 5x68 G.H5 D 342 G.H5.13
Hydrophobic C-term L 358 - G.h2s4 G 218 G.h2s4.03
Van-der-waals C-term L 358 - G.h2s4 G 218 G.h2s4.03
Hydrophobic C-term L 358 - G.H5 V 343 G.H5.14
Ionic ICL3 R 262 - G.H5 D 342 G.H5.13
Polar ICL3 R 262 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 R 262 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 R 262 - G.H5 D 342 G.H5.13
Hydrophobic ICL2 R 169 34x57 G.H5 I 352 G.H5.23
Van-der-waals ICL2 R 169 34x57 G.H5 I 352 G.H5.23
Polar ICL2 A 166 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 A 166 34x54 G.hns1 R 31 G.hns1.02
Aromatic C-term F 368 - G.H3 W 259 G.H3.17
Hydrophobic C-term F 368 - G.H3 W 259 G.H3.17
Van-der-waals C-term F 368 - G.H3 W 259 G.H3.17
Hydrophobic C-term A 362 - G.h2s4 E 217 G.h2s4.02
Hydrophobic H8 D 328 8x48 G.H5 C 355 G.H5.26
Van-der-waals H8 D 328 8x48 G.H5 C 355 G.H5.26
Hydrophobic ICL2 P 162 34x50 G.H5 I 345 G.H5.16
Ionic ICL3 R 264 - G.h4s6 E 316 G.h4s6.09
Polar ICL3 R 264 - G.h4s6 E 316 G.h4s6.09
Van-der-waals ICL3 R 264 - G.h4s6 E 316 G.h4s6.09
Polar C-term L 358 - G.h2s4 T 220 G.h2s4.05
Hydrophobic C-term L 358 - G.h2s4 T 220 G.h2s4.05
Van-der-waals C-term L 358 - G.h2s4 T 220 G.h2s4.05
Hydrophobic TM6 I 269 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 I 269 6x33 G.H5 L 354 G.H5.25