Gs - SST3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 T 149 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 T 149 34x51 G.S3 V 217 G.S3.01
Ionic TM6 R 254 6x32 G.H5 E 392 G.H5.24
Polar TM6 R 254 6x32 G.H5 E 392 G.H5.24
Hydrophobic C-term L 399 - G.H3 S 275 G.H3.11
Polar C-term Q 397 - G.H2 R 228 G.H2.01
Polar C-term E 354 - G.HN K 28 G.HN.45
Van-der-waals C-term E 354 - G.HN K 28 G.HN.45
Hydrophobic C-term L 399 - G.H2 R 231 G.H2.04
Van-der-waals C-term L 399 - G.H2 R 231 G.H2.04
Polar TM6 R 254 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 254 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 254 6x32 G.H5 L 394 G.H5.26
Polar C-term Q 379 - G.H2 Q 236 G.H2.09
Hydrophobic C-term Q 379 - G.H2 Q 236 G.H2.09
Van-der-waals C-term Q 379 - G.H2 Q 236 G.H2.09
Polar C-term K 347 - G.hns1 Y 37 G.hns1.01
Van-der-waals TM5 R 239 5x71 G.H5 R 380 G.H5.12
Ionic C-term E 351 - G.hns1 R 38 G.hns1.02
Polar C-term E 351 - G.hns1 R 38 G.hns1.02
Hydrophobic C-term E 351 - G.hns1 R 38 G.hns1.02
Van-der-waals C-term E 351 - G.hns1 R 38 G.hns1.02
Hydrophobic C-term V 374 - G.S2 F 208 G.S2.02
Polar C-term S 375 - G.S2 E 209 G.S2.03
Van-der-waals C-term S 375 - G.S2 E 209 G.S2.03
Polar TM3 A 144 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 144 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 144 3x53 G.H5 H 387 G.H5.19
Hydrophobic C-term G 372 - G.h1ha V 65 G.h1ha.01
Ionic C-term D 357 - G.HN K 24 G.HN.41
Polar C-term D 357 - G.HN K 24 G.HN.41
Van-der-waals C-term D 357 - G.HN K 24 G.HN.41
Hydrophobic ICL2 P 148 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 148 34x50 G.H5 R 380 G.H5.12
Ionic C-term E 355 - G.HN K 24 G.HN.41
Polar C-term E 355 - G.HN K 24 G.HN.41
Hydrophobic TM3 A 144 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 144 3x53 G.H5 Y 391 G.H5.23
Ionic H8 K 321 8x51 G.H5 E 392 G.H5.24
Hydrophobic TM3 V 145 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 145 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 K 232 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 232 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 W 241 - G.H4 Y 339 G.H4.08
Polar TM5 R 239 5x71 G.H5 N 377 G.H5.09
Hydrophobic ICL2 P 148 34x50 G.H5 H 387 G.H5.19
Ionic ICL2 R 150 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic C-term P 401 - G.H2 R 231 G.H2.04
Polar C-term I 377 - G.S2 I 207 G.S2.01
Hydrophobic C-term I 377 - G.S2 I 207 G.S2.01
Van-der-waals C-term I 377 - G.S2 I 207 G.S2.01
Hydrophobic ICL3 W 241 - G.hgh4 A 324 G.hgh4.14
Van-der-waals ICL3 W 241 - G.hgh4 A 324 G.hgh4.14
Hydrophobic C-term L 399 - G.H3 E 268 G.H3.04
Van-der-waals C-term L 399 - G.H3 E 268 G.H3.04
Hydrophobic C-term N 371 - G.S2 F 212 G.S2.06
Van-der-waals C-term N 371 - G.S2 F 212 G.S2.06
Hydrophobic ICL3 W 241 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 W 241 - G.hgh4 D 323 G.hgh4.13
Hydrophobic TM6 V 255 6x33 G.H5 L 388 G.H5.20
Polar C-term D 357 - G.HN K 28 G.HN.45
Van-der-waals C-term D 357 - G.HN K 28 G.HN.45
Hydrophobic TM5 A 236 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 A 236 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 V 240 5x72 G.S6 Y 360 G.S6.02
Van-der-waals TM5 V 240 5x72 G.S6 Y 360 G.S6.02
Hydrophobic C-term V 374 - G.S2 T 210 G.S2.04
Hydrophobic C-term I 377 - G.S3 F 222 G.S3.06
Van-der-waals C-term I 377 - G.S3 F 222 G.S3.06
Ionic C-term K 347 - G.h2s4 D 240 G.h2s4.03
Polar C-term K 347 - G.h2s4 D 240 G.h2s4.03
Hydrophobic C-term K 347 - G.h2s4 D 240 G.h2s4.03
Van-der-waals C-term K 347 - G.h2s4 D 240 G.h2s4.03
Ionic C-term D 352 - G.HN K 34 G.HN.51
Polar C-term D 352 - G.HN K 34 G.HN.51
Van-der-waals C-term D 352 - G.HN K 34 G.HN.51
Hydrophobic TM7 L 316 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 L 316 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM6 S 251 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 S 251 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM6 M 258 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 M 258 6x36 G.H5 E 392 G.H5.24
Ionic C-term E 349 - G.hns1 R 38 G.hns1.02
Polar C-term E 349 - G.hns1 R 38 G.hns1.02
Hydrophobic C-term E 349 - G.hns1 R 38 G.hns1.02
Van-der-waals C-term E 349 - G.hns1 R 38 G.hns1.02
Ionic C-term E 403 - G.H3 R 280 G.H3.16
Polar C-term E 403 - G.H3 R 280 G.H3.16
Hydrophobic C-term E 403 - G.H3 R 280 G.H3.16
Van-der-waals C-term E 403 - G.H3 R 280 G.H3.16
Hydrophobic C-term I 377 - G.S2 E 209 G.S2.03
Polar ICL2 R 155 34x57 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 R 155 34x57 G.H5 Y 391 G.H5.23
Polar C-term E 354 - G.HN Q 31 G.HN.48
Hydrophobic C-term E 354 - G.HN Q 31 G.HN.48
Van-der-waals C-term E 354 - G.HN Q 31 G.HN.48
Hydrophobic C-term N 371 - G.h1ha V 65 G.h1ha.01
Van-der-waals C-term N 371 - G.h1ha V 65 G.h1ha.01
Hydrophobic ICL2 T 149 34x51 G.H5 I 383 G.H5.15
Hydrophobic C-term V 374 - G.H1 R 61 G.H1.09
Hydrophobic ICL3 W 241 - G.hgh4 T 325 G.hgh4.15
Hydrophobic TM5 V 240 5x72 G.H5 D 381 G.H5.13
Van-der-waals TM5 V 240 5x72 G.H5 D 381 G.H5.13
Hydrophobic C-term E 354 - G.HN E 27 G.HN.44
Van-der-waals C-term E 354 - G.HN E 27 G.HN.44
Van-der-waals C-term M 370 - G.S2 K 211 G.S2.05
Hydrophobic ICL3 P 243 - G.H4 L 346 G.H4.16
Polar C-term N 371 - G.H1 H 64 G.H1.12
Hydrophobic C-term L 400 - G.H2 W 234 G.H2.07
Van-der-waals C-term L 400 - G.H2 W 234 G.H2.07
Hydrophobic C-term P 344 - G.H3 W 281 G.H3.17
Hydrophobic TM3 V 145 3x54 G.H5 H 387 G.H5.19
Polar ICL2 R 155 34x57 G.H5 H 387 G.H5.19
Aromatic ICL2 R 155 34x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 R 155 34x57 G.H5 H 387 G.H5.19
Van-der-waals ICL2 R 155 34x57 G.H5 H 387 G.H5.19
Hydrophobic TM4 T 156 4x38 G.HN Q 35 G.HN.52
Polar TM2 T 79 2x39 G.H5 Q 390 G.H5.22
Hydrophobic TM2 T 79 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 T 79 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 148 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 148 34x50 G.H5 I 383 G.H5.15
Polar TM3 R 141 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 W 241 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 W 241 - G.H4 R 342 G.H4.12
Hydrophobic ICL2 T 149 34x51 G.S1 H 41 G.S1.02
Polar TM3 D 140 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 140 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 140 3x49 G.H5 Y 391 G.H5.23
Hydrophobic C-term L 400 - G.H3 I 276 G.H3.12
Van-der-waals C-term L 400 - G.H3 I 276 G.H3.12
Polar C-term K 347 - G.h2s4 N 239 G.h2s4.02
Hydrophobic C-term K 347 - G.h2s4 N 239 G.h2s4.02
Van-der-waals C-term K 347 - G.h2s4 N 239 G.h2s4.02
Hydrophobic ICL2 T 149 34x51 G.H5 R 380 G.H5.12
Hydrophobic C-term V 374 - G.S2 E 209 G.S2.03
Van-der-waals C-term V 374 - G.S2 E 209 G.S2.03
Hydrophobic C-term N 371 - G.S2 K 211 G.S2.05
Van-der-waals C-term N 371 - G.S2 K 211 G.S2.05
Hydrophobic C-term E 351 - G.HN K 34 G.HN.51
Hydrophobic C-term E 403 - G.H3 W 281 G.H3.17
Van-der-waals C-term E 403 - G.H3 W 281 G.H3.17
Polar C-term Q 376 - G.hfs2 S 205 G.hfs2.06
Hydrophobic ICL2 P 148 34x50 G.H5 Q 384 G.H5.16
Polar TM6 V 255 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 V 255 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 255 6x33 G.H5 L 393 G.H5.25
Van-der-waals C-term E 353 - G.HN Q 31 G.HN.48
Hydrophobic C-term L 399 - G.H3 L 272 G.H3.08
Ionic C-term K 366 - G.h1ha E 75 G.h1ha.11
Hydrophobic ICL2 A 152 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic C-term Q 376 - G.S2 F 208 G.S2.02
Polar H8 R 319 8x49 G.H5 Q 390 G.H5.22
Hydrophobic H8 R 319 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 R 319 8x49 G.H5 Q 390 G.H5.22
Hydrophobic TM6 M 258 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 M 258 6x36 G.H5 L 393 G.H5.25
Polar C-term E 350 - G.HN K 34 G.HN.51
Hydrophobic C-term E 350 - G.HN K 34 G.HN.51
Van-der-waals C-term E 350 - G.HN K 34 G.HN.51
Hydrophobic TM5 V 233 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 233 5x65 G.H5 L 388 G.H5.20
Van-der-waals C-term Q 376 - G.S2 I 207 G.S2.01
Hydrophobic C-term P 401 - G.H2 R 232 G.H2.05
Ionic TM6 R 248 6x26 G.H5 D 381 G.H5.13
Polar TM6 R 248 6x26 G.H5 D 381 G.H5.13
Polar TM3 V 145 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 145 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 145 3x54 G.H5 Q 384 G.H5.16
Polar H8 Y 318 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 Y 318 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 Y 318 8x48 G.H5 E 392 G.H5.24
Hydrophobic C-term L 399 - G.H3 N 271 G.H3.07
Van-der-waals C-term L 399 - G.H3 N 271 G.H3.07
Polar H8 S 317 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 S 317 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 317 8x47 G.H5 E 392 G.H5.24
Hydrophobic C-term L 400 - G.H3 N 279 G.H3.15
Van-der-waals C-term L 400 - G.H3 N 279 G.H3.15
Polar C-term N 371 - G.S2 Q 213 G.S2.07
Hydrophobic C-term N 371 - G.S2 Q 213 G.S2.07
Van-der-waals C-term N 371 - G.S2 Q 213 G.S2.07
Van-der-waals TM6 R 248 6x26 G.H5 R 385 G.H5.17
Hydrophobic C-term E 356 - G.HN K 28 G.HN.45
Polar ICL3 R 247 - G.h4s6 G 353 G.h4s6.09
Hydrophobic ICL3 R 247 - G.h4s6 G 353 G.h4s6.09
Van-der-waals ICL3 R 247 - G.h4s6 G 353 G.h4s6.09
Hydrophobic C-term L 400 - G.H3 S 275 G.H3.11
Van-der-waals C-term L 400 - G.H3 S 275 G.H3.11
Polar C-term D 352 - G.HN Q 31 G.HN.48
Van-der-waals C-term D 352 - G.HN Q 31 G.HN.48