Gi2 -
SST4 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | L | 371 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Van-der-waals | C-term | L | 371 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Hydrophobic | C-term | Y | 346 | - | G.H3 | L | 250 | G.H3.08 |
Polar | ICL2 | R | 158 | 34x57 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | ICL2 | R | 158 | 34x57 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | ICL2 | R | 158 | 34x57 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | C-term | L | 344 | - | G.H3 | F | 260 | G.H3.18 |
Hydrophobic | ICL2 | P | 151 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | ICL2 | P | 151 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Ionic | ICL2 | R | 158 | 34x57 | G.H5 | D | 351 | G.H5.22 |
Polar | ICL2 | R | 158 | 34x57 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | ICL2 | R | 158 | 34x57 | G.H5 | D | 351 | G.H5.22 |
Van-der-waals | ICL2 | R | 158 | 34x57 | G.H5 | D | 351 | G.H5.22 |
Polar | C-term | R | 379 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Van-der-waals | C-term | R | 379 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Polar | C-term | L | 344 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | C-term | L | 344 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | ICL2 | T | 156 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | T | 156 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Polar | C-term | Y | 347 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | Y | 347 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | Y | 347 | - | G.H2 | R | 206 | G.H2.01 |
Polar | TM2 | T | 82 | 2x39 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | TM2 | T | 82 | 2x39 | G.H5 | D | 351 | G.H5.22 |
Van-der-waals | TM2 | T | 82 | 2x39 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | C-term | E | 374 | - | G.hfs2 | V | 180 | G.hfs2.03 |
Hydrophobic | ICL2 | L | 152 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Van-der-waals | ICL2 | L | 152 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Ionic | C-term | D | 345 | - | G.H2 | R | 209 | G.H2.04 |
Polar | C-term | D | 345 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | D | 345 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | D | 345 | - | G.H2 | R | 209 | G.H2.04 |
Polar | C-term | Y | 347 | - | G.s4h3 | D | 238 | G.s4h3.11 |
Hydrophobic | ICL2 | P | 151 | 34x50 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | TM3 | R | 144 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | R | 144 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | W | 247 | 6x23 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | W | 247 | 6x23 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | C-term | L | 344 | - | G.H2 | I | 213 | G.H2.08 |
Polar | C-term | R | 377 | - | G.hfs2 | T | 182 | G.hfs2.05 |
Hydrophobic | C-term | R | 377 | - | G.hfs2 | T | 182 | G.hfs2.05 |
Van-der-waals | C-term | R | 377 | - | G.hfs2 | T | 182 | G.hfs2.05 |
Polar | TM3 | R | 144 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 144 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 144 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Aromatic | TM6 | K | 256 | 6x32 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | TM6 | K | 256 | 6x32 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | TM6 | K | 256 | 6x32 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | C-term | P | 375 | - | H.HA | V | 72 | H.HA.10 |
Hydrophobic | TM6 | Q | 249 | 6x25 | G.h4s6 | D | 316 | G.h4s6.09 |
Hydrophobic | C-term | L | 344 | - | G.H3 | I | 254 | G.H3.12 |
Van-der-waals | C-term | L | 344 | - | G.H3 | I | 254 | G.H3.12 |
Hydrophobic | C-term | Y | 346 | - | G.H3 | K | 249 | G.H3.07 |
Van-der-waals | C-term | Y | 346 | - | G.H3 | K | 249 | G.H3.07 |
Ionic | C-term | E | 342 | - | G.H3 | K | 258 | G.H3.16 |
Polar | C-term | E | 342 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | C-term | E | 342 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | E | 342 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | TM3 | V | 148 | 3x54 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM3 | V | 148 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | V | 148 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Polar | TM6 | Q | 249 | 6x25 | G.h4s6 | K | 315 | G.h4s6.08 |
Hydrophobic | TM6 | Q | 249 | 6x25 | G.h4s6 | K | 315 | G.h4s6.08 |
Van-der-waals | TM6 | Q | 249 | 6x25 | G.h4s6 | K | 315 | G.h4s6.08 |
Hydrophobic | C-term | L | 382 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | TM6 | S | 253 | 6x29 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | TM6 | S | 253 | 6x29 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | H8 | S | 315 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | H8 | S | 315 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | C-term | P | 375 | - | H.HA | Q | 68 | H.HA.06 |
Polar | TM6 | R | 250 | 6x26 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | TM6 | R | 250 | 6x26 | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | TM6 | R | 250 | 6x26 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | C-term | L | 344 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Van-der-waals | C-term | L | 344 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Polar | TM4 | S | 161 | 4x40 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | C-term | L | 382 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | C-term | Y | 346 | - | G.H2 | R | 209 | G.H2.04 |
Polar | TM6 | W | 247 | 6x23 | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | TM6 | W | 247 | 6x23 | G.S6 | I | 320 | G.S6.01 |
Van-der-waals | TM6 | W | 247 | 6x23 | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | C-term | I | 380 | - | G.S2 | E | 187 | G.S2.03 |
Van-der-waals | C-term | I | 380 | - | G.S2 | E | 187 | G.S2.03 |
Hydrophobic | TM5 | M | 238 | 5x65 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM5 | K | 237 | 5x64 | G.H5 | I | 345 | G.H5.16 |
Polar | H8 | D | 316 | 8x48 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | H8 | D | 316 | 8x48 | G.H5 | F | 355 | G.H5.26 |
Ionic | TM6 | R | 250 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Polar | TM6 | R | 250 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM6 | R | 250 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM6 | R | 250 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Polar | C-term | Y | 346 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | ICL2 | L | 152 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | L | 152 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | ICL2 | A | 155 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | A | 155 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Polar | ICL2 | P | 151 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Polar | TM3 | R | 144 | 3x50 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | C-term | L | 344 | - | G.H3 | N | 257 | G.H3.15 |
Hydrophobic | TM5 | V | 241 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | V | 241 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM6 | I | 257 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | C-term | Q | 372 | - | G.hfs2 | V | 180 | G.hfs2.03 |
Hydrophobic | C-term | R | 377 | - | G.S2 | V | 186 | G.S2.02 |
Van-der-waals | C-term | R | 377 | - | G.S2 | V | 186 | G.S2.02 |
Hydrophobic | TM5 | V | 241 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM2 | T | 80 | 2x37 | G.H5 | D | 351 | G.H5.22 |
Van-der-waals | TM2 | T | 80 | 2x37 | G.H5 | D | 351 | G.H5.22 |
Ionic | TM4 | R | 159 | 4x38 | G.HN | E | 28 | G.HN.52 |
Polar | TM4 | R | 159 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | R | 159 | 4x38 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | R | 159 | 4x38 | G.HN | E | 28 | G.HN.52 |
Polar | C-term | E | 342 | - | G.H3 | N | 257 | G.H3.15 |
Polar | TM2 | T | 82 | 2x39 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM2 | T | 82 | 2x39 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM6 | L | 260 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | P | 151 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | P | 151 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Ionic | C-term | R | 377 | - | G.S3 | D | 201 | G.S3.07 |
Polar | C-term | R | 377 | - | G.S3 | D | 201 | G.S3.07 |
Van-der-waals | C-term | R | 377 | - | G.S3 | D | 201 | G.S3.07 |
Hydrophobic | ICL2 | L | 152 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Polar | C-term | Y | 346 | - | G.H3 | E | 246 | G.H3.04 |
Hydrophobic | C-term | Y | 346 | - | G.H3 | E | 246 | G.H3.04 |
Van-der-waals | C-term | Y | 346 | - | G.H3 | E | 246 | G.H3.04 |
Polar | TM3 | A | 147 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | A | 147 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | A | 147 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM6 | V | 261 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Polar | H8 | N | 317 | 8x49 | G.H5 | K | 350 | G.H5.21 |
Van-der-waals | H8 | N | 317 | 8x49 | G.H5 | K | 350 | G.H5.21 |
Hydrophobic | TM6 | W | 247 | 6x23 | G.H4 | E | 309 | G.H4.16 |
Polar | C-term | Q | 372 | - | H.hbhc | E | 115 | H.hbhc.03 |
Van-der-waals | C-term | Q | 372 | - | H.hbhc | E | 115 | H.hbhc.03 |
Hydrophobic | TM3 | A | 147 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | A | 147 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Ionic | TM6 | R | 250 | 6x26 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | TM6 | R | 250 | 6x26 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM6 | R | 250 | 6x26 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | R | 250 | 6x26 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM5 | M | 238 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM5 | M | 238 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Ionic | C-term | E | 374 | - | G.H1 | K | 51 | G.H1.06 |
Polar | C-term | E | 374 | - | G.H1 | K | 51 | G.H1.06 |
Hydrophobic | C-term | E | 374 | - | G.H1 | K | 51 | G.H1.06 |
Van-der-waals | C-term | E | 374 | - | G.H1 | K | 51 | G.H1.06 |
Hydrophobic | C-term | E | 374 | - | H.HA | Y | 69 | H.HA.07 |