Gt2 - SST5 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 10.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 R 137 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 137 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 137 3x50 G.H5 C 351 G.H5.23
Hydrophobic C-term L 364 - G.S2 T 187 G.S2.04
Hydrophobic TM3 V 141 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 141 3x54 G.H5 L 348 G.H5.20
Polar TM6 K 245 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 245 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 245 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 144 34x50 G.H5 I 343 G.H5.15
Ionic ICL2 R 149 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 149 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 149 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 149 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 A 231 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 145 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM3 A 140 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL3 V 235 - G.S6 H 322 G.S6.04
Van-der-waals ICL3 V 235 - G.S6 H 322 G.S6.04
Hydrophobic C-term M 359 - G.S2 I 184 G.S2.01
Hydrophobic H8 S 308 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 S 146 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 S 146 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 I 224 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM6 V 246 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 145 34x51 G.S3 F 196 G.S3.03
Hydrophobic TM4 P 153 4x39 G.HN D 28 G.HN.52
Van-der-waals TM4 P 153 4x39 G.HN D 28 G.HN.52
Polar TM6 C 237 6x24 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 C 237 6x24 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 C 237 6x24 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 V 228 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 A 231 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 A 231 5x68 G.H5 D 341 G.H5.13
Polar H8 N 310 8x49 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 75 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 R 239 6x26 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 239 6x26 G.H5 K 345 G.H5.17
Hydrophobic ICL3 V 235 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 V 235 - G.H5 D 341 G.H5.13
Hydrophobic TM3 R 137 3x50 G.H5 L 353 G.H5.25
Polar TM2 T 75 2x39 G.H5 D 350 G.H5.22
Polar TM3 A 140 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 140 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 140 3x53 G.H5 N 347 G.H5.19
Ionic ICL1 K 72 12x51 G.HN E 20 G.HN.44
Polar ICL1 K 72 12x51 G.HN E 20 G.HN.44
Van-der-waals ICL1 K 72 12x51 G.HN E 20 G.HN.44
Hydrophobic TM6 C 237 6x24 G.S6 Y 320 G.S6.02
Polar ICL2 R 151 34x57 G.H5 N 347 G.H5.19
Ionic ICL3 R 234 - G.H5 D 337 G.H5.09
Hydrophobic ICL2 S 146 34x52 G.s2s3 K 192 G.s2s3.01
Hydrophobic C-term L 364 - G.H1 K 54 G.H1.09
Van-der-waals C-term L 364 - G.H1 K 54 G.H1.09
Hydrophobic ICL2 A 148 34x54 G.S3 L 194 G.S3.01
Hydrophobic ICL2 P 144 34x50 G.H5 I 344 G.H5.16
Hydrophobic C-term S 362 - G.S2 I 185 G.S2.02
Hydrophobic ICL2 L 145 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 L 145 34x51 G.S2 V 191 G.S2.08
Hydrophobic TM6 V 246 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 246 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 Y 221 5x58 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 148 34x54 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 A 148 34x54 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 L 145 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM6 M 249 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 M 249 6x36 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 144 34x50 G.H5 T 340 G.H5.12
Polar ICL2 L 145 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 L 145 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 L 145 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM4 R 152 4x38 G.hns1 K 32 G.hns1.03
Van-der-waals TM4 R 152 4x38 G.hns1 K 32 G.hns1.03
Hydrophobic ICL3 V 235 - G.H5 D 337 G.H5.09
Ionic TM4 R 154 4x40 G.HN E 25 G.HN.49
Hydrophobic ICL2 A 148 34x54 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 A 148 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic TM3 V 141 3x54 G.H5 I 344 G.H5.16
Polar ICL2 L 145 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 L 145 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 145 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL3 V 235 - G.H5 A 338 G.H5.10
Hydrophobic ICL3 V 235 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 V 235 - G.S6 Y 320 G.S6.02
Polar ICL1 K 72 12x51 G.HN Q 24 G.HN.48
Hydrophobic TM6 V 246 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 S 242 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 S 242 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM5 K 227 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 227 5x64 G.H5 I 344 G.H5.16
Ionic TM6 R 239 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 239 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 239 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 239 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 239 6x26 G.S6 Y 320 G.S6.02
Hydrophobic TM6 R 239 6x26 G.S6 Y 320 G.S6.02
Van-der-waals TM6 R 239 6x26 G.S6 Y 320 G.S6.02
Hydrophobic TM6 M 249 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 249 6x36 G.H5 L 353 G.H5.25
Ionic TM6 R 239 6x26 G.H5 D 341 G.H5.13
Polar TM6 R 239 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 239 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 239 6x26 G.H5 D 341 G.H5.13