Gi3 - succinate receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM4 K 136 4x39 G.HN E 28 G.HN.52
Polar TM4 K 136 4x39 G.HN E 28 G.HN.52
Hydrophobic TM4 K 136 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 K 136 4x39 G.HN E 28 G.HN.52
Hydrophobic TM3 I 124 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 124 3x54 G.H5 L 348 G.H5.20
Polar ICL3 T 223 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 T 223 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 T 223 - G.H5 D 341 G.H5.13
Polar ICL2 P 127 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 127 34x50 G.H5 N 347 G.H5.19
Hydrophobic H8 G 299 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 G 299 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 127 34x50 G.H5 I 343 G.H5.15
Ionic ICL2 R 129 34x52 G.H5 E 350 G.H5.22
Polar ICL2 R 129 34x52 G.H5 E 350 G.H5.22
Van-der-waals ICL2 R 129 34x52 G.H5 E 350 G.H5.22
Hydrophobic TM6 K 229 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 229 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM5 R 217 5x68 G.H5 T 340 G.H5.12
Van-der-waals TM5 R 217 5x68 G.H5 T 340 G.H5.12
Ionic TM5 R 217 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 217 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 217 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 217 5x68 G.H5 D 341 G.H5.13
Polar ICL3 A 224 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 A 224 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 A 224 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 L 225 - G.H5 K 345 G.H5.17
Hydrophobic ICL3 T 223 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 T 223 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 L 225 - G.H5 D 341 G.H5.13
Hydrophobic TM5 R 217 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 217 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 F 128 34x51 G.H5 T 340 G.H5.12
Polar TM3 R 120 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 120 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 F 128 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL3 P 226 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 L 225 - G.H5 Y 354 G.H5.26
Hydrophobic ICL2 F 128 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 128 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM6 L 227 6x30 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 227 6x30 G.H5 L 348 G.H5.20
Hydrophobic ICL3 P 226 - G.H5 Y 354 G.H5.26
Van-der-waals ICL3 P 226 - G.H5 Y 354 G.H5.26
Polar TM3 R 120 3x50 G.H5 G 352 G.H5.24
Polar TM6 P 230 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 P 230 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 P 230 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 F 128 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 128 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM3 I 123 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 123 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 120 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 234 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 221 5x72 G.S6 H 322 G.S6.04
Hydrophobic H8 H 301 8x49 G.H5 E 350 G.H5.22
Hydrophobic ICL3 L 225 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 L 225 - G.S6 Y 320 G.S6.02
Polar ICL3 L 225 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 L 225 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 L 225 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 E 130 34x53 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 E 130 34x53 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 P 127 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM6 L 233 6x36 G.H5 L 353 G.H5.25
Hydrophobic H8 D 300 8x48 G.H5 K 349 G.H5.21
Polar TM2 N 56 2x37 G.H5 E 350 G.H5.22
Hydrophobic TM7 L 298 7x56 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 I 124 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 124 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM4 K 136 4x39 G.HN R 24 G.HN.48
Van-der-waals TM4 K 136 4x39 G.HN R 24 G.HN.48
Hydrophobic TM6 P 230 6x33 G.H5 L 348 G.H5.20
Ionic TM4 E 137 4x40 G.HN R 24 G.HN.48
Polar TM4 E 137 4x40 G.HN R 24 G.HN.48
Polar TM3 I 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 123 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 P 230 6x33 G.H5 Y 354 G.H5.26
Van-der-waals TM6 L 233 6x36 G.H5 G 352 G.H5.24
Hydrophobic ICL2 E 130 34x53 G.s2s3 D 193 G.s2s3.02