Golf - TAS2R14 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 76.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 24.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar TM3 T 78 3x21 G.h4s6 K 343 G.h4s6.12
Hydrophobic TM3 T 78 3x21 G.h4s6 K 343 G.h4s6.12
Van-der-waals TM3 T 78 3x21 G.h4s6 K 343 G.h4s6.12
Hydrophobic ECL1 L 75 - G.H5 K 376 G.H5.21
Van-der-waals ECL1 L 75 - G.H5 K 376 G.H5.21
Hydrophobic ECL2 I 156 - G.H5 L 381 G.H5.26
Polar ECL1 F 76 - G.H5 K 376 G.H5.21
Hydrophobic ECL1 F 76 - G.H5 K 376 G.H5.21
Van-der-waals ECL1 F 76 - G.H5 K 376 G.H5.21
Hydrophobic TM4 I 152 4x64 G.H5 L 381 G.H5.26
Van-der-waals TM4 I 152 4x64 G.H5 L 381 G.H5.26
Polar ECL1 A 77 - G.H5 R 372 G.H5.17
Hydrophobic ECL1 A 77 - G.H5 R 372 G.H5.17
Van-der-waals ECL1 A 77 - G.H5 R 372 G.H5.17
Hydrophobic ECL2 F 172 - G.H5 L 375 G.H5.20
Polar ECL2 N 162 - G.hgh4 D 310 G.hgh4.13
Hydrophobic ECL2 N 162 - G.hgh4 D 310 G.hgh4.13
Van-der-waals ECL2 N 162 - G.hgh4 D 310 G.hgh4.13
Polar ECL1 P 73 - G.H5 H 374 G.H5.19
Hydrophobic ECL1 P 73 - G.H5 H 374 G.H5.19
Van-der-waals ECL1 P 73 - G.H5 H 374 G.H5.19
Hydrophobic ECL2 T 164 - G.S6 F 350 G.S6.05
Van-der-waals ECL2 T 164 - G.S6 F 350 G.S6.05
Hydrophobic TM3 E 79 3x22 G.H5 K 376 G.H5.21
Van-der-waals TM3 E 79 3x22 G.H5 K 376 G.H5.21
Polar TM3 M 81 3x24 G.H5 E 379 G.H5.24
Hydrophobic TM3 M 81 3x24 G.H5 E 379 G.H5.24
Van-der-waals TM3 M 81 3x24 G.H5 E 379 G.H5.24
Polar ECL1 L 75 - G.H5 Q 377 G.H5.22
Hydrophobic ECL1 L 75 - G.H5 Q 377 G.H5.22
Van-der-waals ECL1 L 75 - G.H5 Q 377 G.H5.22
Polar TM3 M 81 3x24 G.H5 Q 377 G.H5.22
Hydrophobic TM3 M 81 3x24 G.H5 Q 377 G.H5.22
Van-der-waals TM3 M 81 3x24 G.H5 Q 377 G.H5.22
Polar ECL2 S 169 - G.H5 R 367 G.H5.12
Hydrophobic ECL2 S 169 - G.H5 R 367 G.H5.12
Van-der-waals ECL2 S 169 - G.H5 R 367 G.H5.12
Polar TM3 E 79 3x22 G.h4s6 Y 345 G.h4s6.20
Hydrophobic TM3 E 79 3x22 G.h4s6 Y 345 G.h4s6.20
Van-der-waals TM3 E 79 3x22 G.h4s6 Y 345 G.h4s6.20
Hydrophobic ECL2 S 155 - G.H5 L 381 G.H5.26
Hydrophobic TM3 F 82 3x25 G.H5 K 376 G.H5.21
Van-der-waals TM3 F 82 3x25 G.H5 K 376 G.H5.21
Van-der-waals TM3 E 79 3x22 G.h4s6 G 342 G.h4s6.11
Polar TM3 T 78 3x21 G.H5 R 372 G.H5.17
Hydrophobic TM3 T 78 3x21 G.H5 R 372 G.H5.17
Van-der-waals TM3 T 78 3x21 G.H5 R 372 G.H5.17
Hydrophobic TM4 I 152 4x64 G.H5 L 380 G.H5.25
Van-der-waals TM4 I 152 4x64 G.H5 L 380 G.H5.25
Polar TM3 F 82 3x25 G.H5 L 381 G.H5.26
Hydrophobic TM3 F 82 3x25 G.H5 L 381 G.H5.26
Van-der-waals TM3 F 82 3x25 G.H5 L 381 G.H5.26
Polar ECL1 F 76 - G.H5 H 374 G.H5.19
Hydrophobic ECL1 F 76 - G.H5 H 374 G.H5.19
Van-der-waals ECL1 F 76 - G.H5 H 374 G.H5.19
Hydrophobic TM3 T 86 3x29 G.H5 L 380 G.H5.25
Van-der-waals TM3 T 86 3x29 G.H5 L 380 G.H5.25
Hydrophobic ECL2 Y 159 - G.S6 Y 347 G.S6.02
Hydrophobic TM3 T 78 3x21 G.h4s6 Y 345 G.h4s6.20
Van-der-waals TM3 T 78 3x21 G.h4s6 Y 345 G.h4s6.20
Hydrophobic ECL2 F 172 - G.H5 Q 371 G.H5.16
Van-der-waals ECL2 F 172 - G.H5 Q 371 G.H5.16
Polar TM3 T 86 3x29 G.H5 E 379 G.H5.24
Van-der-waals TM3 T 86 3x29 G.H5 E 379 G.H5.24
Hydrophobic TM2 V 68 2x63 G.H5 Q 377 G.H5.22
Van-der-waals TM2 V 68 2x63 G.H5 Q 377 G.H5.22
Polar TM3 L 85 3x28 G.H5 E 379 G.H5.24
Hydrophobic TM3 L 85 3x28 G.H5 E 379 G.H5.24
Van-der-waals TM3 L 85 3x28 G.H5 E 379 G.H5.24
Hydrophobic ECL1 A 77 - G.H5 K 376 G.H5.21
Van-der-waals ECL1 A 77 - G.H5 K 376 G.H5.21
Aromatic ECL1 F 76 - G.H5 Y 378 G.H5.23
Hydrophobic ECL1 F 76 - G.H5 Y 378 G.H5.23
Van-der-waals ECL1 F 76 - G.H5 Y 378 G.H5.23
Polar ECL2 C 165 - G.hgh4 T 312 G.hgh4.15
Hydrophobic ECL2 C 165 - G.hgh4 T 312 G.hgh4.15
Van-der-waals ECL2 C 165 - G.hgh4 T 312 G.hgh4.15
Polar ECL1 A 77 - G.H5 M 373 G.H5.18
Hydrophobic ECL1 A 77 - G.H5 M 373 G.H5.18
Van-der-waals ECL1 A 77 - G.H5 M 373 G.H5.18
Hydrophobic ECL2 N 162 - G.H4 L 333 G.H4.16
Van-der-waals ECL2 N 162 - G.H4 L 333 G.H4.16
Hydrophobic TM3 F 82 3x25 G.H5 E 379 G.H5.24
Van-der-waals TM3 F 82 3x25 G.H5 E 379 G.H5.24
Hydrophobic ECL1 F 76 - G.H5 R 372 G.H5.17
Van-der-waals ECL1 F 76 - G.H5 R 372 G.H5.17
Polar TM3 R 83 3x26 G.H5 L 381 G.H5.26
Hydrophobic TM3 R 83 3x26 G.H5 L 381 G.H5.26
Van-der-waals TM3 R 83 3x26 G.H5 L 381 G.H5.26
Hydrophobic ECL1 A 74 - G.H5 M 373 G.H5.18
Van-der-waals ECL1 A 74 - G.H5 M 373 G.H5.18
Van-der-waals ECL1 P 73 - G.H5 M 373 G.H5.18
Polar ECL1 F 76 - G.H5 L 375 G.H5.20
Hydrophobic ECL1 F 76 - G.H5 L 375 G.H5.20
Van-der-waals ECL1 F 76 - G.H5 L 375 G.H5.20
Polar ECL2 N 162 - G.H4 R 329 G.H4.12
Hydrophobic ECL2 N 162 - G.H4 R 329 G.H4.12
Van-der-waals ECL2 N 162 - G.H4 R 329 G.H4.12
Hydrophobic TM3 F 82 3x25 G.H5 Y 378 G.H5.23
Van-der-waals TM3 F 82 3x25 G.H5 Y 378 G.H5.23
Hydrophobic TM2 S 69 2x64 G.H5 Y 378 G.H5.23
Van-der-waals TM2 S 69 2x64 G.H5 Y 378 G.H5.23
Hydrophobic TM3 K 80 3x23 G.H5 K 376 G.H5.21
Hydrophobic TM3 T 78 3x21 G.h4s6 H 344 G.h4s6.13
Hydrophobic TM3 M 81 3x24 G.H5 K 376 G.H5.21
Van-der-waals TM3 M 81 3x24 G.H5 K 376 G.H5.21
Polar TM3 F 82 3x25 G.H5 L 380 G.H5.25
Hydrophobic TM3 F 82 3x25 G.H5 L 380 G.H5.25
Van-der-waals TM3 F 82 3x25 G.H5 L 380 G.H5.25
Hydrophobic TM3 F 82 3x25 G.H5 L 375 G.H5.20
Van-der-waals TM3 F 82 3x25 G.H5 L 375 G.H5.20
Polar ECL1 F 76 - G.H5 Q 377 G.H5.22
Hydrophobic ECL1 F 76 - G.H5 Q 377 G.H5.22
Van-der-waals ECL1 F 76 - G.H5 Q 377 G.H5.22
Hydrophobic ECL3 L 257 - G.H5 R 367 G.H5.12
Polar TM3 T 78 3x21 G.h4s6 G 342 G.h4s6.11
Aromatic TM2 F 72 2x67 G.hns1 K 40 G.hns1.02
Polar TM3 M 84 3x27 G.H5 E 379 G.H5.24
Hydrophobic TM3 M 84 3x27 G.H5 E 379 G.H5.24
Van-der-waals TM3 M 84 3x27 G.H5 E 379 G.H5.24
Hydrophobic ECL2 T 164 - G.S6 P 348 G.S6.03
Hydrophobic TM3 L 85 3x28 G.H5 L 380 G.H5.25
Van-der-waals TM3 L 85 3x28 G.H5 L 380 G.H5.25
Polar ECL2 T 164 - G.H4 R 329 G.H4.12
Hydrophobic ECL2 T 164 - G.H4 R 329 G.H4.12
Ionic TM3 K 80 3x23 G.h4s6 D 341 G.h4s6.10
Polar TM3 K 80 3x23 G.h4s6 D 341 G.h4s6.10
Van-der-waals TM3 K 80 3x23 G.h4s6 D 341 G.h4s6.10
Polar ECL2 Y 159 - G.H5 D 368 G.H5.13
Hydrophobic ECL2 Y 159 - G.H5 D 368 G.H5.13
Van-der-waals ECL2 Y 159 - G.H5 D 368 G.H5.13
Polar TM3 T 78 3x21 G.H5 K 376 G.H5.21
Hydrophobic TM3 T 78 3x21 G.H5 K 376 G.H5.21
Van-der-waals TM3 T 78 3x21 G.H5 K 376 G.H5.21
Polar TM2 S 65 2x60 G.H5 Y 378 G.H5.23
Hydrophobic TM2 S 65 2x60 G.H5 Y 378 G.H5.23
Van-der-waals TM2 S 65 2x60 G.H5 Y 378 G.H5.23
Polar ECL2 Y 159 - G.H5 R 372 G.H5.17
Aromatic ECL2 Y 159 - G.H5 R 372 G.H5.17
Hydrophobic ECL2 Y 159 - G.H5 R 372 G.H5.17
Van-der-waals ECL2 Y 159 - G.H5 R 372 G.H5.17
Polar TM2 F 71 2x66 G.hns1 K 40 G.hns1.02
Hydrophobic TM2 F 71 2x66 G.hns1 K 40 G.hns1.02
Van-der-waals TM2 F 71 2x66 G.hns1 K 40 G.hns1.02
Ionic ECL2 R 161 - G.hgh4 D 310 G.hgh4.13
Polar ECL2 R 161 - G.hgh4 D 310 G.hgh4.13
Hydrophobic ECL2 R 161 - G.hgh4 D 310 G.hgh4.13
Van-der-waals ECL2 R 161 - G.hgh4 D 310 G.hgh4.13
Polar ECL1 F 76 - G.H5 M 373 G.H5.18
Hydrophobic ECL1 F 76 - G.H5 M 373 G.H5.18
Van-der-waals ECL1 F 76 - G.H5 M 373 G.H5.18
Hydrophobic TM3 L 85 3x28 G.H5 Y 378 G.H5.23
Hydrophobic ECL2 F 175 - G.H5 L 381 G.H5.26
Van-der-waals ECL2 F 175 - G.H5 L 381 G.H5.26
Hydrophobic ECL3 L 257 - G.H5 Q 371 G.H5.16