G15 - TAS2R19 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 17.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 V 223 6x30 G.H5 L 368 G.H5.20
Hydrophobic TM6 T 230 6x37 G.H5 L 373 G.H5.25
Van-der-waals TM6 T 230 6x37 G.H5 L 373 G.H5.25
Hydrophobic TM3 I 110 3x54 G.H5 L 364 G.H5.16
Van-der-waals TM3 I 110 3x54 G.H5 L 364 G.H5.16
Hydrophobic TM3 F 105 3x49 G.H5 I 371 G.H5.23
Hydrophobic TM6 H 224 6x31 G.H5 L 368 G.H5.20
Hydrophobic ICL2 K 123 34x55 G.hns1 G 41 G.hns1.03
Polar TM5 H 205 5x68 G.H5 R 360 G.H5.12
Hydrophobic TM5 H 205 5x68 G.H5 R 360 G.H5.12
Van-der-waals TM5 H 205 5x68 G.H5 R 360 G.H5.12
Hydrophobic TM7 G 282 7x56 G.H5 L 373 G.H5.25
Hydrophobic ICL2 F 113 34x45 G.H5 V 363 G.H5.15
Van-der-waals ICL2 F 113 34x45 G.H5 V 363 G.H5.15
Polar H8 S 283 8x47 G.H5 N 372 G.H5.24
Hydrophobic H8 S 283 8x47 G.H5 N 372 G.H5.24
Van-der-waals H8 S 283 8x47 G.H5 N 372 G.H5.24
Hydrophobic TM3 I 110 3x54 G.H5 L 373 G.H5.25
Hydrophobic ICL2 L 116 34x48 G.s2s3 K 201 G.s2s3.02
Van-der-waals ICL2 L 116 34x48 G.s2s3 K 201 G.s2s3.02
Polar H8 R 284 8x48 G.h4s6 K 331 G.h4s6.13
Hydrophobic H8 R 284 8x48 G.h4s6 K 331 G.h4s6.13
Van-der-waals H8 R 284 8x48 G.h4s6 K 331 G.h4s6.13
Hydrophobic TM3 I 110 3x54 G.H5 L 368 G.H5.20
Van-der-waals TM3 I 110 3x54 G.H5 L 368 G.H5.20
Hydrophobic TM3 C 106 3x50 G.H5 I 371 G.H5.23
Van-der-waals TM3 C 106 3x50 G.H5 I 371 G.H5.23
Polar H8 R 284 8x48 G.H5 L 374 G.H5.26
Hydrophobic H8 R 284 8x48 G.H5 L 374 G.H5.26
Van-der-waals H8 R 284 8x48 G.H5 L 374 G.H5.26
Hydrophobic TM6 H 224 6x31 G.H5 L 364 G.H5.16
Van-der-waals TM6 H 224 6x31 G.H5 L 364 G.H5.16
Hydrophobic ICL2 F 113 34x45 G.H5 L 364 G.H5.16
Van-der-waals ICL2 F 113 34x45 G.H5 L 364 G.H5.16
Hydrophobic TM3 L 102 3x46 G.H5 I 371 G.H5.23
Hydrophobic TM3 K 109 3x53 G.H5 I 371 G.H5.23
Ionic TM3 K 109 3x53 G.H5 E 370 G.H5.22
Polar TM3 K 109 3x53 G.H5 E 370 G.H5.22
Van-der-waals TM3 K 109 3x53 G.H5 E 370 G.H5.22
Polar H8 S 283 8x47 G.H5 L 374 G.H5.26
Hydrophobic H8 S 283 8x47 G.H5 L 374 G.H5.26
Van-der-waals H8 S 283 8x47 G.H5 L 374 G.H5.26
Hydrophobic ICL2 F 113 34x45 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 F 113 34x45 G.H5 Y 367 G.H5.19
Hydrophobic TM6 V 223 6x30 G.H5 L 374 G.H5.26
Van-der-waals TM6 V 223 6x30 G.H5 L 374 G.H5.26
Polar TM6 S 220 6x27 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM6 S 220 6x27 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM6 S 220 6x27 G.h4s6 R 338 G.h4s6.20
Polar H8 Q 288 8x52 G.h4s6 K 331 G.h4s6.13
Van-der-waals H8 Q 288 8x52 G.h4s6 K 331 G.h4s6.13
Hydrophobic TM5 L 202 5x65 G.H5 L 364 G.H5.16
Polar H8 R 284 8x48 G.h4s6 G 333 G.h4s6.15
Hydrophobic H8 R 284 8x48 G.h4s6 G 333 G.h4s6.15
Van-der-waals H8 R 284 8x48 G.h4s6 G 333 G.h4s6.15
Polar TM6 A 227 6x34 G.H5 L 373 G.H5.25
Hydrophobic TM6 A 227 6x34 G.H5 L 373 G.H5.25
Hydrophobic TM3 K 109 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 K 109 3x53 G.H5 Y 367 G.H5.19
Hydrophobic TM6 V 223 6x30 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM6 V 223 6x30 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM5 H 212 5x75 G.H5 K 357 G.H5.09
Van-der-waals TM5 H 212 5x75 G.H5 K 357 G.H5.09
Aromatic TM6 H 224 6x31 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM3 I 110 3x54 G.H5 Y 367 G.H5.19
Polar ICL2 K 123 34x55 G.HN K 37 G.HN.52
Hydrophobic ICL2 K 123 34x55 G.HN K 37 G.HN.52
Van-der-waals ICL2 K 123 34x55 G.HN K 37 G.HN.52
Hydrophobic ICL2 F 113 34x45 G.H5 R 360 G.H5.12
Van-der-waals ICL2 F 113 34x45 G.H5 R 360 G.H5.12
Hydrophobic H8 R 284 8x48 G.h4s6 R 335 G.h4s6.17
Van-der-waals H8 R 284 8x48 G.h4s6 R 335 G.h4s6.17
Hydrophobic TM6 V 231 6x38 G.H5 L 373 G.H5.25
Hydrophobic TM3 C 106 3x50 G.H5 L 373 G.H5.25
Ionic TM5 H 205 5x68 G.H5 D 361 G.H5.13
Polar TM5 H 205 5x68 G.H5 D 361 G.H5.13
Hydrophobic TM5 H 205 5x68 G.H5 D 361 G.H5.13
Van-der-waals TM5 H 205 5x68 G.H5 D 361 G.H5.13
Polar TM7 G 282 7x56 G.H5 L 374 G.H5.26
Hydrophobic TM7 G 282 7x56 G.H5 L 374 G.H5.26
Van-der-waals TM7 G 282 7x56 G.H5 L 374 G.H5.26
Hydrophobic TM3 I 110 3x54 G.H5 I 371 G.H5.23
Van-der-waals TM3 I 110 3x54 G.H5 I 371 G.H5.23
Hydrophobic TM2 A 44 2x39 G.H5 I 371 G.H5.23
Hydrophobic TM2 A 44 2x39 G.H5 E 370 G.H5.22
Van-der-waals TM2 A 44 2x39 G.H5 E 370 G.H5.22
Polar ICL2 K 122 34x54 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 K 122 34x54 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 K 122 34x54 G.H5 Y 367 G.H5.19
Polar ICL2 K 123 34x55 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 K 123 34x55 G.hns1 R 40 G.hns1.02
Hydrophobic TM6 A 227 6x34 G.H5 L 368 G.H5.20
Van-der-waals TM6 A 227 6x34 G.H5 L 368 G.H5.20
Hydrophobic TM5 K 208 5x71 G.H5 R 360 G.H5.12
Hydrophobic TM5 H 205 5x68 G.H5 L 364 G.H5.16
Van-der-waals TM5 H 205 5x68 G.H5 L 364 G.H5.16
Hydrophobic TM5 M 209 5x72 G.H5 D 361 G.H5.13
Van-der-waals TM5 M 209 5x72 G.H5 D 361 G.H5.13
Hydrophobic TM6 K 226 6x33 G.H5 L 374 G.H5.26
Van-der-waals TM6 K 226 6x33 G.H5 L 374 G.H5.26
Hydrophobic ICL2 L 119 34x51 G.S3 T 202 G.S3.01