Golf - TAS2R50 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 25.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 G 215 - G.hgh4 D 310 G.hgh4.13
Hydrophobic ICL3 G 215 - G.hgh4 D 310 G.hgh4.13
Van-der-waals ICL3 G 215 - G.hgh4 D 310 G.hgh4.13
Polar ICL3 E 214 - G.hgh4 T 312 G.hgh4.15
Hydrophobic ICL3 E 214 - G.hgh4 T 312 G.hgh4.15
Van-der-waals ICL3 E 214 - G.hgh4 T 312 G.hgh4.15
Polar TM7 R 282 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM7 R 282 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 R 282 7x56 G.H5 L 380 G.H5.25
Ionic TM5 H 205 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 205 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 205 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 205 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 L 211 5x74 G.hgh4 T 312 G.hgh4.15
Hydrophobic H8 K 284 8x48 G.H5 K 376 G.H5.21
Van-der-waals H8 K 284 8x48 G.H5 K 376 G.H5.21
Hydrophobic ICL2 R 123 34x55 G.s2s3 K 203 G.s2s3.02
Van-der-waals ICL2 R 123 34x55 G.s2s3 K 203 G.s2s3.02
Polar H8 K 284 8x48 G.h4s6 G 342 G.h4s6.11
Van-der-waals H8 K 284 8x48 G.h4s6 G 342 G.h4s6.11
Ionic H8 K 285 8x49 G.H5 E 379 G.H5.24
Hydrophobic H8 K 285 8x49 G.H5 E 379 G.H5.24
Van-der-waals H8 K 285 8x49 G.H5 E 379 G.H5.24
Hydrophobic TM3 L 102 3x46 G.H5 L 380 G.H5.25
Polar TM5 H 212 5x75 G.hgh4 T 312 G.hgh4.15
Hydrophobic TM5 H 212 5x75 G.hgh4 T 312 G.hgh4.15
Van-der-waals TM5 H 212 5x75 G.hgh4 T 312 G.hgh4.15
Polar ICL3 E 214 - G.hgh4 P 313 G.hgh4.16
Hydrophobic ICL3 E 214 - G.hgh4 P 313 G.hgh4.16
Van-der-waals ICL3 E 214 - G.hgh4 P 313 G.hgh4.16
Polar TM6 H 224 6x31 G.H5 R 372 G.H5.17
Hydrophobic TM6 H 224 6x31 G.H5 R 372 G.H5.17
Van-der-waals TM6 H 224 6x31 G.H5 R 372 G.H5.17
Hydrophobic H8 K 284 8x48 G.H5 L 381 G.H5.26
Polar ICL3 E 214 - G.hgh4 A 311 G.hgh4.14
Hydrophobic ICL3 E 214 - G.hgh4 A 311 G.hgh4.14
Van-der-waals ICL3 E 214 - G.hgh4 A 311 G.hgh4.14
Hydrophobic TM4 R 126 4x39 G.HN L 37 G.HN.52
Van-der-waals TM4 R 126 4x39 G.HN L 37 G.HN.52
Polar TM5 H 212 5x75 G.H5 R 361 G.H5.06
Hydrophobic TM5 H 212 5x75 G.H5 R 361 G.H5.06
Van-der-waals TM5 H 212 5x75 G.H5 R 361 G.H5.06
Hydrophobic TM2 S 42 2x37 G.H5 Y 378 G.H5.23
Van-der-waals TM2 S 42 2x37 G.H5 Y 378 G.H5.23
Hydrophobic TM5 L 202 5x65 G.H5 R 372 G.H5.17
Polar ICL3 E 214 - G.hgh4 D 310 G.hgh4.13
Hydrophobic ICL3 E 214 - G.hgh4 D 310 G.hgh4.13
Van-der-waals ICL3 E 214 - G.hgh4 D 310 G.hgh4.13
Hydrophobic TM3 F 105 3x49 G.H5 L 380 G.H5.25
Van-der-waals TM3 F 105 3x49 G.H5 L 380 G.H5.25
Polar TM3 Y 106 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM3 Y 106 3x50 G.H5 L 380 G.H5.25
Van-der-waals TM3 Y 106 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM3 K 109 3x53 G.H5 L 375 G.H5.20
Van-der-waals TM3 K 109 3x53 G.H5 L 375 G.H5.20
Hydrophobic ICL1 K 40 - G.HN R 36 G.HN.51
Van-der-waals ICL1 K 40 - G.HN R 36 G.HN.51
Polar TM5 G 213 5x76 G.hgh4 T 312 G.hgh4.15
Hydrophobic TM5 G 213 5x76 G.hgh4 T 312 G.hgh4.15
Van-der-waals TM5 G 213 5x76 G.hgh4 T 312 G.hgh4.15
Hydrophobic TM2 A 44 2x39 G.H5 Y 378 G.H5.23
Van-der-waals TM2 A 44 2x39 G.H5 Y 378 G.H5.23
Hydrophobic TM3 I 110 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 110 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM6 L 219 6x26 G.h4s6 T 337 G.h4s6.03
Polar ICL2 N 112 34x44 G.H5 Q 371 G.H5.16
Hydrophobic ICL2 N 112 34x44 G.H5 Q 371 G.H5.16
Van-der-waals ICL2 N 112 34x44 G.H5 Q 371 G.H5.16
Polar ICL2 K 122 34x54 G.H5 Q 371 G.H5.16
Hydrophobic ICL2 K 122 34x54 G.H5 Q 371 G.H5.16
Van-der-waals ICL2 K 122 34x54 G.H5 Q 371 G.H5.16
Hydrophobic TM2 A 44 2x39 G.H5 L 380 G.H5.25
Van-der-waals TM2 A 44 2x39 G.H5 L 380 G.H5.25
Hydrophobic TM3 K 109 3x53 G.H5 Y 378 G.H5.23
Van-der-waals TM3 K 109 3x53 G.H5 Y 378 G.H5.23
Van-der-waals TM7 R 282 7x56 G.H5 L 381 G.H5.26
Polar ICL2 N 112 34x44 G.H5 D 368 G.H5.13
Hydrophobic ICL2 N 112 34x44 G.H5 D 368 G.H5.13
Van-der-waals ICL2 N 112 34x44 G.H5 D 368 G.H5.13
Polar TM5 H 205 5x68 G.H5 R 372 G.H5.17
Aromatic TM5 H 205 5x68 G.H5 R 372 G.H5.17
Hydrophobic TM5 H 205 5x68 G.H5 R 372 G.H5.17
Van-der-waals TM5 H 205 5x68 G.H5 R 372 G.H5.17
Polar TM6 D 218 6x25 G.hgh4 D 310 G.hgh4.13
Hydrophobic TM3 I 110 3x54 G.H5 L 381 G.H5.26
Van-der-waals TM3 I 110 3x54 G.H5 L 381 G.H5.26
Polar ICL2 N 112 34x44 G.H5 R 367 G.H5.12
Hydrophobic ICL2 N 112 34x44 G.H5 R 367 G.H5.12
Van-der-waals ICL2 N 112 34x44 G.H5 R 367 G.H5.12
Hydrophobic TM6 A 227 6x34 G.H5 L 381 G.H5.26
Van-der-waals TM6 A 227 6x34 G.H5 L 381 G.H5.26
Hydrophobic TM3 I 110 3x54 G.H5 R 372 G.H5.17
Ionic TM5 K 208 5x71 G.H5 D 365 G.H5.10
Polar TM5 K 208 5x71 G.H5 D 365 G.H5.10
Van-der-waals TM5 K 208 5x71 G.H5 D 365 G.H5.10
Polar H8 K 284 8x48 G.h4s6 K 343 G.h4s6.12
Polar H8 K 284 8x48 G.h4s6 Y 345 G.h4s6.20
Hydrophobic H8 K 284 8x48 G.h4s6 Y 345 G.h4s6.20
Van-der-waals H8 K 284 8x48 G.h4s6 Y 345 G.h4s6.20
Ionic ICL2 R 123 34x55 G.s2s3 D 202 G.s2s3.01
Polar ICL2 R 123 34x55 G.s2s3 D 202 G.s2s3.01
Hydrophobic ICL2 R 123 34x55 G.s2s3 D 202 G.s2s3.01
Van-der-waals ICL2 R 123 34x55 G.s2s3 D 202 G.s2s3.01
Polar H8 T 283 8x47 G.H5 E 379 G.H5.24
Hydrophobic H8 T 283 8x47 G.H5 E 379 G.H5.24
Van-der-waals H8 T 283 8x47 G.H5 E 379 G.H5.24
Hydrophobic TM6 V 223 6x30 G.H5 K 376 G.H5.21
Van-der-waals TM6 V 223 6x30 G.H5 K 376 G.H5.21
Hydrophobic ICL1 K 40 - G.hns1 K 40 G.hns1.02
Van-der-waals ICL1 K 40 - G.hns1 K 40 G.hns1.02
Hydrophobic ICL2 L 119 34x51 G.s2s3 D 202 G.s2s3.01