Golf - TAS2R1 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 L 44 2x39 G.H5 E 379 G.H5.24
Hydrophobic TM3 V 107 3x54 G.H5 H 374 G.H5.19
Polar TM3 K 106 3x53 G.H5 H 374 G.H5.19
Hydrophobic TM3 K 106 3x53 G.H5 H 374 G.H5.19
Van-der-waals TM3 K 106 3x53 G.H5 H 374 G.H5.19
Polar ICL2 K 119 34x54 G.H5 H 374 G.H5.19
Hydrophobic ICL2 K 119 34x54 G.H5 H 374 G.H5.19
Van-der-waals ICL2 K 119 34x54 G.H5 H 374 G.H5.19
Ionic ICL2 R 111 34x46 G.s2s3 D 202 G.s2s3.01
Polar ICL2 R 111 34x46 G.s2s3 D 202 G.s2s3.01
Hydrophobic ICL2 R 111 34x46 G.s2s3 D 202 G.s2s3.01
Van-der-waals ICL2 R 111 34x46 G.s2s3 D 202 G.s2s3.01
Polar TM5 H 204 5x68 G.H5 Q 371 G.H5.16
Hydrophobic TM5 H 204 5x68 G.H5 Q 371 G.H5.16
Van-der-waals TM5 H 204 5x68 G.H5 Q 371 G.H5.16
Hydrophobic TM6 I 230 6x38 G.H5 L 380 G.H5.25
Polar H8 N 281 8x47 G.H5 E 379 G.H5.24
Hydrophobic H8 N 281 8x47 G.H5 E 379 G.H5.24
Van-der-waals H8 N 281 8x47 G.H5 E 379 G.H5.24
Hydrophobic TM6 P 223 6x31 G.H5 L 375 G.H5.20
Hydrophobic TM5 T 211 5x75 G.H5 N 364 G.H5.09
Van-der-waals TM5 T 211 5x75 G.H5 N 364 G.H5.09
Hydrophobic TM2 L 44 2x39 G.H5 Y 378 G.H5.23
Hydrophobic TM3 Y 103 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM7 G 280 7x56 G.H5 E 379 G.H5.24
Van-der-waals TM7 G 280 7x56 G.H5 E 379 G.H5.24
Polar TM7 G 280 7x56 G.H5 L 381 G.H5.26
Polar TM3 K 106 3x53 G.H5 Y 378 G.H5.23
Hydrophobic TM3 K 106 3x53 G.H5 Y 378 G.H5.23
Van-der-waals TM3 K 106 3x53 G.H5 Y 378 G.H5.23
Polar ICL3 A 213 - G.hgh4 T 312 G.hgh4.15
Hydrophobic TM6 A 226 6x34 G.H5 L 375 G.H5.20
Van-der-waals TM6 A 226 6x34 G.H5 L 375 G.H5.20
Hydrophobic ICL2 M 120 34x55 G.hns1 K 40 G.hns1.02
Van-der-waals ICL2 M 120 34x55 G.hns1 K 40 G.hns1.02
Hydrophobic TM6 S 229 6x37 G.H5 L 380 G.H5.25
Polar TM5 Q 207 5x71 G.H5 R 367 G.H5.12
Hydrophobic TM5 Q 207 5x71 G.H5 R 367 G.H5.12
Van-der-waals TM5 Q 207 5x71 G.H5 R 367 G.H5.12
Polar TM6 A 226 6x34 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 226 6x34 G.H5 L 380 G.H5.25
Van-der-waals TM6 A 226 6x34 G.H5 L 380 G.H5.25
Hydrophobic TM6 V 217 6x25 G.S6 Y 347 G.S6.02
Van-der-waals TM6 V 217 6x25 G.S6 Y 347 G.S6.02
Hydrophobic TM6 V 217 6x25 G.H5 R 372 G.H5.17
Ionic ICL3 R 216 - G.hgh4 D 310 G.hgh4.13
Polar ICL3 R 216 - G.hgh4 D 310 G.hgh4.13
Hydrophobic ICL3 R 216 - G.hgh4 D 310 G.hgh4.13
Van-der-waals ICL3 R 216 - G.hgh4 D 310 G.hgh4.13
Hydrophobic H8 P 282 8x48 G.H5 L 381 G.H5.26
Van-der-waals H8 P 282 8x48 G.H5 L 381 G.H5.26
Hydrophobic H8 P 282 8x48 G.H5 E 379 G.H5.24
Hydrophobic TM5 M 208 5x72 G.H5 R 367 G.H5.12
Hydrophobic TM3 V 107 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 107 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM6 P 218 6x26 G.h4s6 Y 345 G.h4s6.20
Aromatic TM3 F 102 3x49 G.H5 Y 378 G.H5.23
Hydrophobic TM3 F 102 3x49 G.H5 Y 378 G.H5.23
Van-der-waals TM3 F 102 3x49 G.H5 Y 378 G.H5.23
Hydrophobic TM6 G 219 6x27 G.h4s6 Y 345 G.h4s6.20
Hydrophobic TM6 A 222 6x30 G.H5 R 372 G.H5.17
Van-der-waals TM6 A 222 6x30 G.H5 R 372 G.H5.17
Polar TM6 S 225 6x33 G.H5 L 380 G.H5.25
Polar TM5 H 204 5x68 G.H5 R 367 G.H5.12
Aromatic TM5 H 204 5x68 G.H5 R 367 G.H5.12
Hydrophobic TM5 H 204 5x68 G.H5 R 367 G.H5.12
Van-der-waals TM5 H 204 5x68 G.H5 R 367 G.H5.12
Polar ICL3 G 214 - G.H4 R 329 G.H4.12
Van-der-waals ICL3 G 214 - G.H4 R 329 G.H4.12
Hydrophobic ICL2 R 111 34x46 G.H5 F 363 G.H5.08
Van-der-waals ICL2 R 111 34x46 G.H5 F 363 G.H5.08
Polar TM5 Q 207 5x71 G.H5 N 364 G.H5.09
Van-der-waals TM5 Q 207 5x71 G.H5 N 364 G.H5.09
Polar TM6 G 219 6x27 G.H5 R 372 G.H5.17
Hydrophobic TM6 G 219 6x27 G.H5 R 372 G.H5.17
Van-der-waals TM6 G 219 6x27 G.H5 R 372 G.H5.17
Hydrophobic TM6 A 222 6x30 G.H5 L 381 G.H5.26
Van-der-waals TM6 A 222 6x30 G.H5 L 381 G.H5.26
Hydrophobic TM5 L 201 5x65 G.H5 Q 371 G.H5.16
Van-der-waals TM5 L 201 5x65 G.H5 Q 371 G.H5.16
Ionic TM5 H 204 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 204 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 204 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 204 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 M 208 5x72 G.H5 N 364 G.H5.09
Van-der-waals TM5 M 208 5x72 G.H5 N 364 G.H5.09
Hydrophobic ICL2 M 120 34x55 G.HN L 37 G.HN.52
Van-der-waals ICL2 M 120 34x55 G.HN L 37 G.HN.52
Hydrophobic TM5 L 201 5x65 G.H5 L 375 G.H5.20
Polar TM3 Y 103 3x50 G.H5 Y 378 G.H5.23
Hydrophobic TM3 Y 103 3x50 G.H5 Y 378 G.H5.23
Van-der-waals TM3 Y 103 3x50 G.H5 Y 378 G.H5.23
Polar ICL3 S 215 - G.S6 P 348 G.S6.03
Hydrophobic ICL3 S 215 - G.S6 P 348 G.S6.03
Van-der-waals ICL3 S 215 - G.S6 P 348 G.S6.03
Hydrophobic TM5 M 208 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 M 208 5x72 G.H5 D 368 G.H5.13
Hydrophobic H8 K 283 8x49 G.H5 E 379 G.H5.24
Van-der-waals H8 K 283 8x49 G.H5 E 379 G.H5.24
Hydrophobic TM3 V 107 3x54 G.H5 Y 378 G.H5.23
Polar ICL3 G 214 - G.hgh4 T 312 G.hgh4.15
Van-der-waals ICL3 G 214 - G.hgh4 T 312 G.hgh4.15
Hydrophobic TM3 V 107 3x54 G.H5 L 380 G.H5.25