GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 25.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | I | 110 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | I | 110 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Polar | TM2 | S | 42 | 2x37 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | S | 42 | 2x37 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | S | 42 | 2x37 | G.H5 | Y | 391 | G.H5.23 |
Ionic | ICL1 | R | 40 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Polar | ICL1 | R | 40 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Van-der-waals | ICL1 | R | 40 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Hydrophobic | TM2 | S | 43 | 2x38 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | P | 220 | 6x26 | G.h4s6 | Y | 358 | G.h4s6.20 |
Polar | ICL2 | N | 112 | 34x44 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | ICL2 | N | 112 | 34x44 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | ICL2 | N | 112 | 34x44 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | ICL3 | F | 217 | - | G.H4 | Y | 339 | G.H4.08 |
Hydrophobic | ICL3 | F | 217 | - | G.hgh4 | P | 321 | G.hgh4.11 |
Van-der-waals | ICL3 | F | 217 | - | G.hgh4 | P | 321 | G.hgh4.11 |
Polar | TM1 | H | 39 | 1x65 | G.HN | K | 34 | G.HN.51 |
Polar | ICL2 | K | 122 | 34x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | K | 122 | 34x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | ICL2 | K | 122 | 34x54 | G.H5 | Q | 384 | G.H5.16 |
Polar | TM6 | Q | 221 | 6x27 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM6 | Q | 221 | 6x27 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | Q | 221 | 6x27 | G.H5 | R | 385 | G.H5.17 |
Aromatic | ICL1 | R | 40 | - | G.hns1 | Y | 37 | G.hns1.01 |
Aromatic | ICL3 | F | 217 | - | G.H4 | R | 342 | G.H4.12 |
Hydrophobic | ICL3 | F | 217 | - | G.H4 | R | 342 | G.H4.12 |
Van-der-waals | ICL3 | F | 217 | - | G.H4 | R | 342 | G.H4.12 |
Hydrophobic | TM3 | K | 109 | 3x53 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | K | 109 | 3x53 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL2 | Q | 114 | 34x46 | G.s2s3 | D | 215 | G.s2s3.01 |
Van-der-waals | ICL2 | Q | 114 | 34x46 | G.s2s3 | D | 215 | G.s2s3.01 |
Polar | ICL2 | N | 112 | 34x44 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | N | 112 | 34x44 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | ICL2 | N | 112 | 34x44 | G.H5 | Q | 384 | G.H5.16 |
Polar | ICL3 | F | 217 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL3 | F | 217 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | F | 217 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL1 | R | 40 | - | G.HN | K | 34 | G.HN.51 |
Van-der-waals | ICL1 | R | 40 | - | G.HN | K | 34 | G.HN.51 |
Ionic | H8 | H | 284 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Polar | H8 | H | 284 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | H | 284 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | H | 284 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM3 | L | 105 | 3x49 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | L | 105 | 3x49 | G.H5 | L | 393 | G.H5.25 |
Polar | TM2 | S | 44 | 2x39 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM2 | S | 44 | 2x39 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM2 | S | 44 | 2x39 | G.H5 | L | 393 | G.H5.25 |
Polar | TM2 | S | 44 | 2x39 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM2 | S | 44 | 2x39 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM2 | S | 44 | 2x39 | G.H5 | E | 392 | G.H5.24 |
Ionic | TM5 | H | 206 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Polar | TM5 | H | 206 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM5 | H | 206 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | H | 206 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Ionic | H8 | K | 286 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Polar | H8 | K | 286 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | K | 286 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | K | 286 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Polar | TM5 | H | 206 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Aromatic | TM5 | H | 206 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | H | 206 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | H | 206 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Polar | TM2 | S | 44 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL3 | W | 218 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | TM6 | P | 220 | 6x26 | G.S6 | Y | 360 | G.S6.02 |
Hydrophobic | H8 | H | 284 | 8x47 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | Q | 221 | 6x27 | G.H5 | I | 382 | G.H5.14 |
Van-der-waals | TM6 | Q | 221 | 6x27 | G.H5 | I | 382 | G.H5.14 |
Hydrophobic | TM2 | D | 45 | 2x40 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM2 | D | 45 | 2x40 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM4 | P | 127 | 4x40 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | TM4 | P | 127 | 4x40 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM3 | K | 109 | 3x53 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | K | 109 | 3x53 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | L | 119 | 34x51 | G.s2s3 | D | 215 | G.s2s3.01 |
Van-der-waals | ICL2 | L | 119 | 34x51 | G.s2s3 | D | 215 | G.s2s3.01 |
Hydrophobic | TM6 | Q | 221 | 6x27 | G.S6 | Y | 360 | G.S6.02 |
Van-der-waals | TM6 | Q | 221 | 6x27 | G.S6 | Y | 360 | G.S6.02 |
Polar | ICL1 | I | 41 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL1 | I | 41 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL1 | I | 41 | - | G.hns1 | R | 38 | G.hns1.02 |
Polar | TM6 | H | 225 | 6x31 | G.H5 | R | 385 | G.H5.17 |
Aromatic | TM6 | H | 225 | 6x31 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM6 | H | 225 | 6x31 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | H | 225 | 6x31 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL1 | R | 40 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL1 | R | 40 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM2 | S | 42 | 2x37 | G.H5 | E | 392 | G.H5.24 |
Polar | TM5 | N | 213 | 5x75 | G.H5 | D | 378 | G.H5.10 |
Hydrophobic | TM5 | M | 210 | 5x72 | G.H5 | D | 378 | G.H5.10 |
Van-der-waals | TM5 | M | 210 | 5x72 | G.H5 | D | 378 | G.H5.10 |
Polar | ICL3 | G | 216 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL3 | G | 216 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | G | 216 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Polar | ICL3 | G | 216 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Hydrophobic | ICL3 | G | 216 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Van-der-waals | ICL3 | G | 216 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Hydrophobic | H8 | P | 285 | 8x48 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | H8 | P | 285 | 8x48 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM3 | I | 110 | 3x54 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | L | 119 | 34x51 | G.s2s3 | K | 216 | G.s2s3.02 |
Polar | ICL2 | S | 116 | 34x48 | G.s2s3 | K | 216 | G.s2s3.02 |
Hydrophobic | TM6 | A | 228 | 6x34 | G.H5 | L | 394 | G.H5.26 |
Polar | ICL3 | T | 215 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Hydrophobic | ICL3 | T | 215 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Van-der-waals | ICL3 | T | 215 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Hydrophobic | H8 | P | 285 | 8x48 | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | H8 | P | 285 | 8x48 | G.H5 | R | 389 | G.H5.21 |
Polar | TM3 | Y | 106 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM3 | Y | 106 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | Y | 106 | 3x50 | G.H5 | L | 393 | G.H5.25 |