Gs - TAS2R5 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 18.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 R 209 - G.h4s6 S 349 G.h4s6.02
Van-der-waals ICL3 R 209 - G.h4s6 S 349 G.h4s6.02
Hydrophobic ICL3 R 209 - G.H4 L 346 G.H4.16
Van-der-waals ICL3 R 209 - G.H4 L 346 G.H4.16
Polar TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 107 3x54 G.H5 Q 384 G.H5.16
Polar TM2 Y 44 2x39 G.H5 E 392 G.H5.24
Polar ICL2 T 109 34x44 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 T 109 34x44 G.H5 Q 384 G.H5.16
Ionic ICL2 D 111 34x46 G.H5 R 380 G.H5.12
Polar ICL2 D 111 34x46 G.H5 R 380 G.H5.12
Hydrophobic ICL2 D 111 34x46 G.H5 R 380 G.H5.12
Van-der-waals ICL2 D 111 34x46 G.H5 R 380 G.H5.12
Polar TM6 R 213 6x27 G.H5 R 385 G.H5.17
Hydrophobic TM6 R 213 6x27 G.H5 R 385 G.H5.17
Van-der-waals TM6 R 213 6x27 G.H5 R 385 G.H5.17
Polar TM3 K 106 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 K 106 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 K 106 3x53 G.H5 Y 391 G.H5.23
Ionic TM5 H 198 5x68 G.H5 D 381 G.H5.13
Polar TM5 H 198 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 198 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 198 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM6 H 217 6x31 G.H5 Q 384 G.H5.16
Van-der-waals TM6 H 217 6x31 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 195 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 107 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 M 202 5x72 G.H5 D 381 G.H5.13
Van-der-waals TM5 M 202 5x72 G.H5 D 381 G.H5.13
Polar TM3 Y 103 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 Y 103 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 103 3x50 G.H5 Y 391 G.H5.23
Polar TM5 H 198 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 198 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 198 5x68 G.H5 Q 384 G.H5.16
Ionic TM6 H 217 6x31 G.H5 D 381 G.H5.13
Polar TM6 H 217 6x31 G.H5 D 381 G.H5.13
Van-der-waals TM6 H 217 6x31 G.H5 D 381 G.H5.13
Polar TM3 K 106 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 K 106 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 K 106 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM6 A 216 6x30 G.H5 L 394 G.H5.26
Van-der-waals TM6 A 216 6x30 G.H5 L 394 G.H5.26
Hydrophobic TM7 G 275 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 G 275 7x56 G.H5 E 392 G.H5.24
Aromatic TM3 F 102 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 F 102 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 F 102 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM6 A 220 6x34 G.H5 L 388 G.H5.20
Hydrophobic TM3 I 107 3x54 G.H5 L 393 G.H5.25
Van-der-waals TM3 I 107 3x54 G.H5 L 393 G.H5.25
Polar H8 I 276 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 I 276 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 I 276 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 107 3x54 G.H5 H 387 G.H5.19
Polar ICL2 T 109 34x44 G.H5 R 380 G.H5.12
Hydrophobic ICL2 T 109 34x44 G.H5 R 380 G.H5.12
Van-der-waals ICL2 T 109 34x44 G.H5 R 380 G.H5.12
Polar TM6 A 220 6x34 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 220 6x34 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 220 6x34 G.H5 L 393 G.H5.25
Aromatic TM6 R 213 6x27 G.S6 Y 360 G.S6.02
Hydrophobic TM6 R 213 6x27 G.S6 Y 360 G.S6.02
Van-der-waals TM6 R 213 6x27 G.S6 Y 360 G.S6.02
Hydrophobic TM1 W 30 1x56 G.H5 E 392 G.H5.24
Van-der-waals TM1 W 30 1x56 G.H5 E 392 G.H5.24
Polar TM5 S 194 5x64 G.H5 Q 384 G.H5.16
Polar ICL3 R 209 - G.S6 C 359 G.S6.01
Hydrophobic ICL3 R 209 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 R 209 - G.S6 C 359 G.S6.01
Hydrophobic TM6 H 217 6x31 G.H5 L 388 G.H5.20
Hydrophobic TM3 Y 103 3x50 G.H5 L 393 G.H5.25
Van-der-waals TM3 Y 103 3x50 G.H5 L 393 G.H5.25
Polar ICL3 G 208 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 G 208 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 G 208 - G.hgh4 D 323 G.hgh4.13
Hydrophobic TM5 M 202 5x72 G.S6 Y 360 G.S6.02
Hydrophobic TM5 L 195 5x65 G.H5 Q 384 G.H5.16
Polar TM6 R 213 6x27 G.S6 C 359 G.S6.01
Hydrophobic TM6 R 213 6x27 G.S6 C 359 G.S6.01
Van-der-waals TM6 R 213 6x27 G.S6 C 359 G.S6.01
Hydrophobic ICL3 A 207 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 A 207 - G.hgh4 D 323 G.hgh4.13
Polar TM6 H 217 6x31 G.H5 R 385 G.H5.17
Hydrophobic ICL3 A 207 - G.hgh4 T 325 G.hgh4.15
Hydrophobic H8 P 277 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM5 M 202 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 M 202 5x72 G.H5 R 385 G.H5.17
Polar TM2 Y 44 2x39 G.H5 Y 391 G.H5.23
Aromatic TM2 Y 44 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 Y 44 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 Y 44 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 R 209 - G.S6 P 361 G.S6.03
Van-der-waals ICL3 R 209 - G.S6 P 361 G.S6.03
Hydrophobic TM3 I 107 3x54 G.H5 L 388 G.H5.20