Gz - TAS2R5 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM7 G 275 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 G 275 7x56 G.H5 G 353 G.H5.24
Hydrophobic TM5 H 198 5x68 G.H5 T 341 G.H5.12
Van-der-waals TM5 K 201 5x71 G.H5 Q 334 G.H5.05
Hydrophobic TM6 H 217 6x31 G.H5 I 345 G.H5.16
Van-der-waals TM6 H 217 6x31 G.H5 I 345 G.H5.16
Polar TM2 S 42 2x37 G.H5 Y 351 G.H5.22
Van-der-waals TM2 S 42 2x37 G.H5 Y 351 G.H5.22
Polar TM6 R 213 6x27 G.H5 Q 346 G.H5.17
Hydrophobic TM6 R 213 6x27 G.H5 Q 346 G.H5.17
Van-der-waals TM6 R 213 6x27 G.H5 Q 346 G.H5.17
Hydrophobic TM3 I 107 3x54 G.H5 L 354 G.H5.25
Polar TM3 K 106 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 K 106 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 K 106 3x53 G.H5 N 348 G.H5.19
Ionic TM5 K 201 5x71 G.H5 D 338 G.H5.09
Polar TM5 K 201 5x71 G.H5 D 338 G.H5.09
Hydrophobic TM5 K 201 5x71 G.H5 D 338 G.H5.09
Van-der-waals TM5 K 201 5x71 G.H5 D 338 G.H5.09
Polar ICL3 A 207 - G.H4 Q 305 G.H4.12
Polar TM6 S 223 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM6 S 223 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM5 M 202 5x72 G.H5 D 338 G.H5.09
Van-der-waals TM5 M 202 5x72 G.H5 D 338 G.H5.09
Hydrophobic TM5 H 198 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 H 198 5x68 G.H5 I 345 G.H5.16
Hydrophobic TM5 M 202 5x72 G.H5 A 339 G.H5.10
Ionic TM6 R 213 6x27 G.h4s6 E 319 G.h4s6.12
Polar TM6 R 213 6x27 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 R 213 6x27 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 R 213 6x27 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 I 107 3x54 G.H5 I 352 G.H5.23
Van-der-waals TM3 I 107 3x54 G.H5 I 352 G.H5.23
Hydrophobic TM5 L 195 5x65 G.H5 I 345 G.H5.16
Van-der-waals TM5 L 195 5x65 G.H5 I 345 G.H5.16
Polar TM6 R 213 6x27 G.S5 S 264 G.S5.01
Hydrophobic TM6 R 213 6x27 G.S5 S 264 G.S5.01
Van-der-waals TM6 R 213 6x27 G.S5 S 264 G.S5.01
Hydrophobic TM3 F 102 3x49 G.H5 I 352 G.H5.23
Ionic ICL2 D 111 34x46 G.s2s3 K 193 G.s2s3.01
Polar ICL2 D 111 34x46 G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 D 111 34x46 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 D 111 34x46 G.s2s3 K 193 G.s2s3.01
Hydrophobic TM5 L 195 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM5 M 202 5x72 G.S6 Y 321 G.S6.02
Van-der-waals TM5 M 202 5x72 G.S6 Y 321 G.S6.02
Ionic TM5 H 205 5x75 G.H5 D 338 G.H5.09
Aromatic ICL3 R 209 - G.S6 Y 321 G.S6.02
Hydrophobic ICL3 R 209 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 R 209 - G.S6 Y 321 G.S6.02
Hydrophobic TM6 A 220 6x34 G.H5 L 349 G.H5.20
Van-der-waals TM6 A 220 6x34 G.H5 L 349 G.H5.20
Hydrophobic TM3 K 106 3x53 G.H5 I 352 G.H5.23
Hydrophobic ICL2 L 116 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 116 34x51 G.hns1 R 32 G.hns1.03
Polar TM3 Y 103 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 Y 103 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 Y 103 3x50 G.H5 I 352 G.H5.23
Polar TM6 H 217 6x31 G.H5 Q 346 G.H5.17
Van-der-waals TM6 H 217 6x31 G.H5 Q 346 G.H5.17
Hydrophobic TM5 H 205 5x75 G.S6 H 323 G.S6.04
Hydrophobic TM3 I 107 3x54 G.H5 N 348 G.H5.19
Hydrophobic TM3 Y 103 3x50 G.H5 L 354 G.H5.25
Ionic ICL3 R 209 - G.h4s6 E 319 G.h4s6.12
Polar ICL3 R 209 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 R 209 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 R 209 - G.h4s6 E 319 G.h4s6.12
Aromatic TM5 H 205 5x75 G.H5 F 335 G.H5.06
Hydrophobic TM5 H 205 5x75 G.H5 F 335 G.H5.06
Van-der-waals TM5 H 205 5x75 G.H5 F 335 G.H5.06
Aromatic TM3 K 106 3x53 G.H5 Y 351 G.H5.22
Hydrophobic TM3 K 106 3x53 G.H5 Y 351 G.H5.22
Van-der-waals TM3 K 106 3x53 G.H5 Y 351 G.H5.22
Hydrophobic TM3 I 107 3x54 G.H5 I 345 G.H5.16
Van-der-waals TM3 I 107 3x54 G.H5 I 345 G.H5.16
Hydrophobic ICL2 T 109 34x44 G.H5 I 345 G.H5.16
Polar TM6 R 213 6x27 G.S6 Y 321 G.S6.02
Hydrophobic TM6 R 213 6x27 G.S6 Y 321 G.S6.02
Van-der-waals TM6 R 213 6x27 G.S6 Y 321 G.S6.02
Hydrophobic TM3 I 107 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 107 3x54 G.H5 L 349 G.H5.20
Polar ICL3 R 209 - G.S6 I 320 G.S6.01
Hydrophobic ICL3 R 209 - G.S6 I 320 G.S6.01
Van-der-waals ICL3 R 209 - G.S6 I 320 G.S6.01
Hydrophobic TM6 D 211 6x25 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 D 211 6x25 G.h4s6 E 319 G.h4s6.12
Hydrophobic H8 I 276 8x47 G.H5 I 352 G.H5.23
Polar TM7 G 275 7x56 G.H5 C 355 G.H5.26
Hydrophobic TM6 V 212 6x26 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 V 212 6x26 G.h4s6 E 316 G.h4s6.09
Hydrophobic ICL2 L 116 34x51 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 L 116 34x51 G.s2s3 E 194 G.s2s3.02
Polar TM6 V 212 6x26 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 V 212 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 A 216 6x30 G.H5 Q 346 G.H5.17
Hydrophobic TM6 V 212 6x26 G.h4s6 K 315 G.h4s6.08
Van-der-waals TM6 V 212 6x26 G.h4s6 K 315 G.h4s6.08
Polar TM6 A 220 6x34 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 220 6x34 G.H5 L 354 G.H5.25
Van-der-waals TM6 R 213 6x27 G.H5 V 343 G.H5.14
Hydrophobic ICL2 T 109 34x44 G.H5 T 341 G.H5.12
Van-der-waals ICL2 T 109 34x44 G.H5 T 341 G.H5.12
Ionic TM6 H 217 6x31 G.H5 D 342 G.H5.13
Polar TM6 H 217 6x31 G.H5 D 342 G.H5.13
Hydrophobic TM6 H 217 6x31 G.H5 D 342 G.H5.13
Van-der-waals TM6 H 217 6x31 G.H5 D 342 G.H5.13
Polar TM2 Y 44 2x39 G.H5 I 352 G.H5.23
Hydrophobic TM2 Y 44 2x39 G.H5 I 352 G.H5.23
Van-der-waals TM2 Y 44 2x39 G.H5 I 352 G.H5.23
Polar TM5 H 198 5x68 G.H5 D 338 G.H5.09
Hydrophobic TM5 M 202 5x72 G.H5 D 342 G.H5.13
Hydrophobic TM6 A 216 6x30 G.H5 C 355 G.H5.26
Polar H8 I 276 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 I 276 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 I 276 8x47 G.H5 G 353 G.H5.24
Ionic TM5 H 198 5x68 G.H5 D 342 G.H5.13
Polar TM5 H 198 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 H 198 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 H 198 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM2 Y 44 2x39 G.H5 Y 351 G.H5.22