GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 85.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | I | 111 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 111 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Ionic | TM5 | R | 214 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Polar | TM5 | R | 214 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | TM5 | R | 214 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | TM5 | R | 214 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Polar | TM4 | R | 128 | 4x40 | G.HN | L | 23 | G.HN.47 |
Van-der-waals | TM4 | R | 128 | 4x40 | G.HN | L | 23 | G.HN.47 |
Hydrophobic | ICL2 | F | 115 | 34x46 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | ICL2 | N | 113 | 34x44 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | H | 230 | 6x31 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM6 | H | 230 | 6x31 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM3 | I | 111 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | A | 229 | 6x30 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | A | 229 | 6x30 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | D | 224 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL2 | F | 115 | 34x46 | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | F | 115 | 34x46 | G.s2s3 | K | 192 | G.s2s3.01 |
Polar | TM3 | K | 110 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | K | 110 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | K | 110 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | I | 111 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | I | 44 | 2x39 | G.H5 | E | 350 | G.H5.22 |
Ionic | TM6 | H | 230 | 6x31 | G.H5 | D | 341 | G.H5.13 |
Polar | TM6 | H | 230 | 6x31 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | H | 230 | 6x31 | G.H5 | D | 341 | G.H5.13 |
Aromatic | TM6 | R | 232 | 6x33 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | R | 232 | 6x33 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 232 | 6x33 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM3 | I | 111 | 3x54 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM5 | S | 218 | 5x75 | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | TM3 | Y | 106 | 3x49 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | L | 120 | 34x51 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | L | 120 | 34x51 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | TM6 | S | 226 | 6x27 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | S | 226 | 6x27 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | S | 226 | 6x27 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | A | 233 | 6x34 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM6 | A | 233 | 6x34 | G.H5 | L | 348 | G.H5.20 |
Ionic | TM4 | R | 128 | 4x40 | G.HN | E | 28 | G.HN.52 |
Polar | TM7 | G | 288 | 7x56 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM7 | G | 288 | 7x56 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM3 | I | 111 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | M | 215 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | M | 215 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Ionic | TM5 | H | 211 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | H | 211 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | H | 211 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | H | 211 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | M | 215 | 5x72 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | TM3 | Y | 107 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | W | 124 | 34x55 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM5 | H | 211 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | H | 211 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | M | 215 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Polar | TM6 | P | 225 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | P | 225 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM2 | I | 44 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Polar | TM6 | A | 233 | 6x34 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | A | 233 | 6x34 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | A | 233 | 6x34 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | K | 110 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | K | 110 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Ionic | TM3 | K | 110 | 3x53 | G.H5 | E | 350 | G.H5.22 |
Polar | TM3 | K | 110 | 3x53 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM3 | K | 110 | 3x53 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | TM3 | K | 110 | 3x53 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM4 | R | 125 | 4x37 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | R | 125 | 4x37 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM5 | H | 211 | 5x68 | G.H5 | T | 340 | G.H5.12 |
Polar | ICL3 | T | 220 | - | G.S6 | T | 321 | G.S6.03 |
Hydrophobic | TM5 | L | 208 | 5x65 | G.H5 | I | 344 | G.H5.16 |
Ionic | TM4 | R | 125 | 4x37 | G.HN | E | 28 | G.HN.52 |
Polar | TM4 | R | 125 | 4x37 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | R | 125 | 4x37 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | R | 125 | 4x37 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM6 | V | 237 | 6x38 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | F | 240 | 6x41 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM7 | G | 288 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM7 | G | 288 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | W | 124 | 34x55 | G.hns1 | A | 31 | G.hns1.02 |
Polar | TM6 | S | 226 | 6x27 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | S | 226 | 6x27 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | S | 226 | 6x27 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | A | 236 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Polar | TM5 | R | 214 | 5x71 | G.H5 | Q | 333 | G.H5.05 |
Van-der-waals | TM5 | R | 214 | 5x71 | G.H5 | Q | 333 | G.H5.05 |
Hydrophobic | TM6 | H | 230 | 6x31 | G.H5 | L | 348 | G.H5.20 |
Polar | TM7 | G | 288 | 7x56 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM7 | G | 288 | 7x56 | G.H5 | L | 353 | G.H5.25 |
Polar | TM4 | R | 128 | 4x40 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM4 | R | 128 | 4x40 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | R | 128 | 4x40 | G.HN | R | 24 | G.HN.48 |
Polar | H8 | N | 289 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | N | 289 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | N | 289 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Polar | H8 | N | 290 | 8x48 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | H8 | N | 290 | 8x48 | G.H5 | Y | 354 | G.H5.26 |
Polar | TM3 | Y | 107 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | Y | 107 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | Y | 107 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Aromatic | ICL2 | W | 124 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | W | 124 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | W | 124 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | N | 113 | 34x44 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | N | 113 | 34x44 | G.H5 | T | 340 | G.H5.12 |