Gi1 - TA1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 87.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 A 133 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 231 5x79 G.H4 C 305 G.H4.13
Hydrophobic H8 W 310 8x49 G.H5 D 350 G.H5.22
Hydrophobic TM6 K 245 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 245 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM3 V 125 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM6 T 252 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 128 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 128 34x50 G.H5 I 344 G.H5.16
Polar ICL2 K 132 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 K 132 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 K 132 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL3 L 235 - G.H4 C 305 G.H4.13
Polar TM5 Q 220 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 Q 220 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 Q 220 5x68 G.H5 D 341 G.H5.13
Van-der-waals ICL2 P 128 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM5 Q 220 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 Q 220 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 223 5x71 G.H5 D 341 G.H5.13
Hydrophobic TM6 L 253 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 253 6x37 G.H5 L 353 G.H5.25
Polar TM5 A 227 5x75 G.H4 Q 304 G.H4.12
Hydrophobic ICL2 L 129 34x51 G.S3 F 196 G.S3.03
Hydrophobic TM5 I 213 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 213 5x61 G.H5 L 353 G.H5.25
Ionic ICL2 R 130 34x52 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 130 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 130 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 130 34x52 G.s2s3 D 193 G.s2s3.02
Polar H8 Y 308 8x47 G.H5 D 350 G.H5.22
Hydrophobic H8 Y 308 8x47 G.H5 D 350 G.H5.22
Van-der-waals H8 Y 308 8x47 G.H5 D 350 G.H5.22
Hydrophobic TM5 L 231 5x79 G.H4 A 301 G.H4.08
Van-der-waals TM5 L 231 5x79 G.H4 A 301 G.H4.08
Polar H8 Y 308 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 Y 308 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 Y 308 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 L 129 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 129 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 P 128 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 128 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 129 34x51 G.H5 T 340 G.H5.12
Polar TM6 T 252 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM6 T 252 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 T 252 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM5 Q 220 5x68 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 129 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 L 129 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM5 I 213 5x61 G.H5 L 348 G.H5.20
Polar ICL2 R 130 34x52 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 R 130 34x52 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 R 130 34x52 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM5 A 221 5x69 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 121 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 121 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 128 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL2 L 129 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 129 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM5 I 224 5x72 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 I 224 5x72 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 V 125 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 125 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 129 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 129 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM4 I 137 4x39 G.HN R 24 G.HN.48
Van-der-waals TM4 I 137 4x39 G.HN R 24 G.HN.48
Hydrophobic TM5 I 224 5x72 G.S6 Y 320 G.S6.02
Polar TM6 K 248 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 248 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 248 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM5 A 217 5x65 G.H5 L 348 G.H5.20
Hydrophobic C-term L 337 - G.h3s5 T 260 G.h3s5.01
Polar H8 Y 308 8x47 G.H5 C 351 G.H5.23
Hydrophobic H8 Y 308 8x47 G.H5 C 351 G.H5.23
Van-der-waals H8 Y 308 8x47 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 224 5x72 G.H5 F 354 G.H5.26
Van-der-waals TM5 I 224 5x72 G.H5 F 354 G.H5.26
Polar TM6 A 249 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 249 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 249 6x33 G.H5 L 353 G.H5.25
Hydrophobic C-term L 337 - G.h4s6 R 313 G.h4s6.04
Hydrophobic TM5 L 231 5x79 G.H4 Q 304 G.H4.12
Van-der-waals TM5 L 231 5x79 G.H4 Q 304 G.H4.12
Polar TM3 A 124 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 124 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 124 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 125 3x54 G.H5 I 344 G.H5.16
Ionic TM6 K 245 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 245 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 K 245 6x29 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 245 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 I 216 5x64 G.H5 I 344 G.H5.16