Gs - TAAR2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 85.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 149 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 149 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM6 L 264 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 264 6x37 G.H5 L 393 G.H5.25
Polar C-term K 348 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term K 348 - G.h4s6 R 356 G.h4s6.12
Hydrophobic ICL2 T 153 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 T 153 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM6 K 256 6x29 G.H5 L 394 G.H5.26
Hydrophobic H8 W 321 8x49 G.H5 Q 390 G.H5.22
Van-der-waals H8 W 321 8x49 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 S 152 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 Y 151 34x53 G.H5 H 387 G.H5.19
Ionic TM6 K 259 6x32 G.H5 E 392 G.H5.24
Polar TM6 K 259 6x32 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 259 6x32 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 259 6x32 G.H5 E 392 G.H5.24
Hydrophobic ICL2 L 150 34x52 G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 150 34x52 G.S3 V 217 G.S3.01
Hydrophobic TM3 I 145 3x54 G.H5 H 387 G.H5.19
Hydrophobic H8 Y 319 8x47 G.H5 Q 390 G.H5.22
Van-der-waals H8 Y 319 8x47 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 L 149 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 149 34x51 G.H5 F 376 G.H5.08
Polar TM3 A 144 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 144 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 144 3x53 G.H5 H 387 G.H5.19
Polar TM6 T 263 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 263 6x36 G.H5 E 392 G.H5.24
Polar TM5 H 239 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 239 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 239 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM4 T 156 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 T 156 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM6 T 263 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM5 S 236 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM2 T 76 2x37 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 P 148 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 148 34x50 G.H5 I 383 G.H5.15
Ionic TM5 H 239 5x68 G.H5 D 381 G.H5.13
Polar TM5 H 239 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 239 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 239 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 I 243 5x72 G.H5 R 385 G.H5.17
Aromatic TM3 R 141 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 145 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 145 3x54 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 148 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 148 34x50 G.H5 R 380 G.H5.12
Polar TM3 I 145 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 145 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 145 3x54 G.H5 Q 384 G.H5.16
Polar H8 Y 319 8x47 G.H5 Y 391 G.H5.23
Hydrophobic H8 Y 319 8x47 G.H5 Y 391 G.H5.23
Hydrophobic TM3 A 144 3x53 G.H5 Y 391 G.H5.23
Polar ICL2 S 152 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 S 152 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 S 152 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM6 A 260 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 260 6x33 G.H5 L 393 G.H5.25
Hydrophobic C-term Q 347 - G.h3s5 T 284 G.h3s5.02
Van-der-waals C-term Q 347 - G.h3s5 T 284 G.h3s5.02
Hydrophobic TM3 I 145 3x54 G.H5 L 388 G.H5.20
Polar ICL2 L 149 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 149 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 149 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM5 H 239 5x68 G.H5 L 394 G.H5.26
Polar TM6 K 259 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 259 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 259 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM5 V 235 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 149 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL2 L 150 34x52 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 L 150 34x52 G.s2s3 K 216 G.s2s3.02
Hydrophobic TM5 A 240 5x69 G.H5 L 394 G.H5.26
Hydrophobic TM5 I 243 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 243 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 I 232 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 I 232 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 243 5x72 G.H5 L 394 G.H5.26
Polar TM5 S 236 5x65 G.H5 L 393 G.H5.25
Van-der-waals TM5 S 236 5x65 G.H5 L 393 G.H5.25
Polar C-term Q 347 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term Q 347 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term Q 347 - G.h4s6 R 356 G.h4s6.12
Polar TM5 H 239 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 239 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 239 5x68 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 148 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 148 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 149 34x51 G.H5 C 379 G.H5.11
Polar ICL3 R 247 - G.h4s6 G 353 G.h4s6.09
Van-der-waals ICL3 R 247 - G.h4s6 G 353 G.h4s6.09
Hydrophobic TM5 H 239 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 H 239 5x68 G.H5 L 388 G.H5.20
Hydrophobic ICL2 L 149 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 149 34x51 G.H5 I 383 G.H5.15