G12 - TAAR6 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 83.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 15.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 P 141 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 P 141 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM4 V 146 4x39 G.HN R 52 G.HN.52
Hydrophobic ICL2 L 138 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM6 A 256 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 256 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 138 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 138 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM3 V 134 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM3 R 130 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 130 3x50 G.H5 I 378 G.H5.23
Polar ICL3 Y 245 - G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL3 Y 245 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 Y 245 - G.h4s6 S 343 G.h4s6.12
Polar TM6 E 253 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 E 253 6x30 G.H5 Q 372 G.H5.17
Polar H8 Y 315 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 Y 315 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 Y 315 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM5 T 238 5x79 G.H4 Q 333 G.H4.13
Polar ICL3 Y 245 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL3 Y 245 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 Y 245 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 L 138 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 138 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM3 A 133 3x53 G.H5 I 378 G.H5.23
Polar ICL1 H 64 12x51 G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 H 64 12x51 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 T 259 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM5 A 224 5x65 G.H5 M 379 G.H5.24
Hydrophobic TM5 V 223 5x64 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 138 34x51 G.H5 V 366 G.H5.11
Hydrophobic ICL2 P 137 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM2 P 66 2x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 P 66 2x38 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 L 138 34x51 G.S3 F 223 G.S3.03
Hydrophobic TM6 A 256 6x33 G.H5 Q 381 G.H5.26
Van-der-waals TM6 A 256 6x33 G.H5 Q 381 G.H5.26
Polar TM3 T 135 3x55 G.H5 K 367 G.H5.12
Hydrophobic ICL2 P 137 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 137 34x50 G.H5 I 370 G.H5.15
Polar TM6 R 252 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 R 252 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 252 6x29 G.H5 Q 381 G.H5.26
Polar ICL3 Y 245 - G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL3 Y 245 - G.h4s6 K 344 G.h4s6.19
Van-der-waals ICL3 Y 245 - G.h4s6 K 344 G.h4s6.19
Ionic TM5 K 230 5x71 G.H5 D 368 G.H5.13
Polar TM5 K 230 5x71 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 230 5x71 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 230 5x71 G.H5 D 368 G.H5.13
Hydrophobic ICL2 L 138 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 138 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM6 A 257 6x34 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 257 6x34 G.H5 M 379 G.H5.24
Hydrophobic TM6 T 259 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 T 259 6x36 G.H5 L 380 G.H5.25
Van-der-waals ICL2 P 137 34x50 G.H5 N 374 G.H5.19
Polar H8 Y 315 8x47 G.H5 D 377 G.H5.22
Hydrophobic H8 Y 315 8x47 G.H5 D 377 G.H5.22
Van-der-waals H8 Y 315 8x47 G.H5 D 377 G.H5.22
Hydrophobic TM5 A 224 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM3 R 130 3x50 G.H5 L 380 G.H5.25
Van-der-waals TM3 R 130 3x50 G.H5 L 380 G.H5.25
Polar ICL2 T 142 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 T 142 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 T 142 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 I 231 5x72 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 V 134 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 134 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 P 137 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 137 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 P 141 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 P 141 34x54 G.hns1 R 55 G.hns1.02
Polar ICL3 S 241 - G.h4s6 R 342 G.h4s6.11
Hydrophobic TM6 L 260 6x37 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 260 6x37 G.H5 M 379 G.H5.24
Hydrophobic TM5 Q 227 5x68 G.H5 L 375 G.H5.20
Hydrophobic TM7 F 314 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 314 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM3 V 134 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 134 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM6 L 260 6x37 G.H5 I 378 G.H5.23
Polar TM3 A 133 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 133 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 133 3x53 G.H5 N 374 G.H5.19
Polar TM5 Q 227 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 Q 227 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 Q 227 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM2 S 65 2x37 G.hns1 R 55 G.hns1.02
Polar C-term H 344 - G.H3 K 284 G.H3.16
Hydrophobic C-term E 343 - G.h3s5 F 287 G.h3s5.01
Polar TM5 Q 227 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM5 Q 227 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 Q 227 5x68 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 V 139 34x52 G.S3 I 221 G.S3.01
Hydrophobic H8 P 316 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 P 316 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM5 I 231 5x72 G.H5 Q 372 G.H5.17
Van-der-waals TM5 I 231 5x72 G.H5 Q 372 G.H5.17
Hydrophobic TM5 Q 227 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 Q 227 5x68 G.H5 L 371 G.H5.16
Polar ICL3 Y 245 - G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL3 Y 245 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 Y 245 - G.h4s6 R 342 G.h4s6.11
Hydrophobic TM7 I 310 7x52 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 138 34x51 G.H5 K 367 G.H5.12