G12 - TPRA1 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 70.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.5
PAE mean: 25.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term S 293 - G.H3 T 279 G.H3.11
Hydrophobic C-term F 338 - H.HA L 115 H.HA.29
Van-der-waals C-term F 338 - H.HA L 115 H.HA.29
Hydrophobic C-term F 338 - H.HA A 111 H.HA.25
Polar ICL2 H 141 - G.H5 L 380 G.H5.25
Hydrophobic ICL2 H 141 - G.H5 L 380 G.H5.25
Van-der-waals ICL2 H 141 - G.H5 L 380 G.H5.25
Hydrophobic C-term F 338 - H.hdhe F 173 H.hdhe.01
Hydrophobic C-term Y 294 - G.H3 I 276 G.H3.08
Polar TM4 S 146 4x40 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 S 146 4x40 G.hns1 R 55 G.hns1.02
Hydrophobic C-term L 308 - H.HB E 135 H.HB.13
Polar C-term Y 294 - G.H2 R 235 G.H2.04
Aromatic C-term Y 294 - G.H2 R 235 G.H2.04
Hydrophobic C-term Y 294 - G.H2 R 235 G.H2.04
Van-der-waals C-term Y 294 - G.H2 R 235 G.H2.04
Polar C-term D 299 - G.H2 S 233 G.H2.02
Hydrophobic C-term D 299 - G.H2 S 233 G.H2.02
Van-der-waals C-term D 299 - G.H2 S 233 G.H2.02
Hydrophobic C-term T 336 - H.HA V 107 H.HA.21
Hydrophobic C-term Y 333 - H.HB M 132 H.HB.10
Van-der-waals C-term Y 333 - H.HB M 132 H.HB.10
Polar C-term Y 333 - H.HA K 114 H.HA.28
Van-der-waals C-term Y 333 - H.HA K 114 H.HA.28
Hydrophobic C-term S 335 - H.HA V 107 H.HA.21
Van-der-waals C-term S 335 - H.HA V 107 H.HA.21
Hydrophobic C-term F 292 - G.H3 I 276 G.H3.08
Van-der-waals C-term F 292 - G.H3 I 276 G.H3.08
Polar ICL2 G 140 - G.H5 Q 381 G.H5.26
Hydrophobic ICL2 G 140 - G.H5 Q 381 G.H5.26
Van-der-waals ICL2 G 140 - G.H5 Q 381 G.H5.26
Ionic C-term K 289 - G.h2s4 D 243 G.h2s4.02
Polar C-term K 289 - G.h2s4 D 243 G.h2s4.02
Van-der-waals C-term K 289 - G.h2s4 D 243 G.h2s4.02
Hydrophobic C-term S 335 - H.hdhe F 173 H.hdhe.01
Van-der-waals C-term S 335 - H.hdhe F 173 H.hdhe.01
Van-der-waals TM4 K 145 4x39 G.hns1 R 55 G.hns1.02
Hydrophobic C-term L 291 - G.H2 F 239 G.H2.08
Van-der-waals C-term L 291 - G.H2 F 239 G.H2.08
Ionic C-term E 303 - G.s4h3 R 265 G.s4h3.12
Polar C-term Y 294 - G.H2 R 232 G.H2.01
Hydrophobic C-term Y 294 - G.H2 R 232 G.H2.01
Van-der-waals C-term Y 294 - G.H2 R 232 G.H2.01
Hydrophobic C-term T 336 - H.HA A 111 H.HA.25
Van-der-waals C-term T 336 - H.HA A 111 H.HA.25
Polar C-term T 336 - H.HA K 114 H.HA.28
Hydrophobic C-term T 336 - H.HA K 114 H.HA.28
Van-der-waals C-term T 336 - H.HA K 114 H.HA.28
Polar ICL1 T 75 - G.h2s4 D 243 G.h2s4.02
Hydrophobic ICL1 T 75 - G.h2s4 D 243 G.h2s4.02
Van-der-waals ICL1 T 75 - G.h2s4 D 243 G.h2s4.02
Polar C-term Y 294 - G.H3 E 272 G.H3.04
Hydrophobic C-term Y 294 - G.H3 E 272 G.H3.04
Van-der-waals C-term Y 294 - G.H3 E 272 G.H3.04
Polar TM4 S 144 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM4 S 144 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 S 144 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 G 140 - G.H5 L 380 G.H5.25
Van-der-waals ICL2 G 140 - G.H5 L 380 G.H5.25
Hydrophobic ICL1 S 76 - G.h2s4 G 244 G.h2s4.03
Polar ICL2 H 141 - G.H5 M 379 G.H5.24
Hydrophobic ICL2 H 141 - G.H5 M 379 G.H5.24
Van-der-waals ICL2 H 141 - G.H5 M 379 G.H5.24
Hydrophobic TM4 K 145 4x39 G.HN R 51 G.HN.51
Van-der-waals TM4 K 145 4x39 G.HN R 51 G.HN.51
Polar C-term S 334 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term S 334 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term S 334 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term Y 333 - H.HA D 110 H.HA.24
Van-der-waals C-term Y 333 - H.HA D 110 H.HA.24
Polar C-term S 335 - H.hdhe Q 174 H.hdhe.02
Hydrophobic C-term S 335 - H.hdhe Q 174 H.hdhe.02
Van-der-waals C-term S 335 - H.hdhe Q 174 H.hdhe.02
Hydrophobic C-term F 338 - H.HD E 172 H.HD.12
Hydrophobic C-term K 289 - G.H3 L 285 G.H3.17
Van-der-waals C-term K 289 - G.H3 L 285 G.H3.17
Polar C-term P 311 - H.HB E 135 H.HB.13
Hydrophobic C-term P 311 - H.HB E 135 H.HB.13
Van-der-waals C-term P 311 - H.HB E 135 H.HB.13
Hydrophobic C-term F 292 - G.H3 I 280 G.H3.12
Van-der-waals C-term F 292 - G.H3 I 280 G.H3.12
Hydrophobic C-term L 308 - H.HA R 106 H.HA.20
Van-der-waals C-term L 308 - H.HA R 106 H.HA.20
Polar C-term I 290 - G.H3 N 283 G.H3.15
Van-der-waals C-term I 290 - G.H3 N 283 G.H3.15
Ionic C-term D 305 - G.hfs2 K 209 G.hfs2.06
Polar C-term D 305 - G.hfs2 K 209 G.hfs2.06
Polar C-term Q 297 - G.H2 R 232 G.H2.01
Hydrophobic C-term Q 297 - G.H2 R 232 G.H2.01
Van-der-waals C-term Q 297 - G.H2 R 232 G.H2.01
Polar C-term D 299 - G.H2 R 232 G.H2.01
Hydrophobic C-term D 299 - G.H2 R 232 G.H2.01
Van-der-waals C-term D 299 - G.H2 R 232 G.H2.01
Hydrophobic ICL1 I 74 - G.h2s4 D 243 G.h2s4.02
Van-der-waals ICL1 I 74 - G.h2s4 D 243 G.h2s4.02
Polar C-term Q 337 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term Q 337 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term Q 337 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term D 299 - G.s4h3 E 263 G.s4h3.10
Van-der-waals C-term D 299 - G.s4h3 E 263 G.s4h3.10
Polar ICL2 E 143 - G.H5 Q 381 G.H5.26
Hydrophobic ICL2 E 143 - G.H5 Q 381 G.H5.26
Van-der-waals ICL2 E 143 - G.H5 Q 381 G.H5.26
Hydrophobic C-term T 336 - H.hdhe F 173 H.hdhe.01
Polar C-term T 336 - H.HA D 110 H.HA.24
Hydrophobic C-term T 336 - H.HA D 110 H.HA.24
Van-der-waals C-term T 336 - H.HA D 110 H.HA.24
Hydrophobic C-term C 296 - G.H2 R 232 G.H2.01
Aromatic C-term F 292 - G.H2 W 238 G.H2.07
Hydrophobic C-term F 292 - G.H2 W 238 G.H2.07
Van-der-waals C-term F 292 - G.H2 W 238 G.H2.07
Hydrophobic C-term F 292 - G.h2s4 F 242 G.h2s4.01
Hydrophobic C-term L 308 - H.HB F 134 H.HB.12
Van-der-waals C-term L 308 - H.HB F 134 H.HB.12
Hydrophobic ICL2 H 141 - G.H5 Q 381 G.H5.26
Van-der-waals ICL2 H 141 - G.H5 Q 381 G.H5.26
Polar C-term Y 333 - H.HA R 106 H.HA.20
Hydrophobic ICL2 L 142 - G.H5 Q 381 G.H5.26
Van-der-waals ICL2 L 142 - G.H5 Q 381 G.H5.26
Hydrophobic C-term F 292 - G.H2 R 235 G.H2.04
Van-der-waals C-term F 292 - G.H2 R 235 G.H2.04
Polar C-term C 296 - G.H2 Q 236 G.H2.05
Hydrophobic C-term C 296 - G.H2 Q 236 G.H2.05
Van-der-waals C-term C 296 - G.H2 Q 236 G.H2.05
Hydrophobic C-term F 338 - H.HA K 114 H.HA.28
Van-der-waals C-term F 338 - H.HA K 114 H.HA.28
Hydrophobic C-term F 292 - G.H3 T 279 G.H3.11
Van-der-waals C-term F 292 - G.H3 T 279 G.H3.11