G12 - TSH receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 A 526 34x50 G.H5 L 371 G.H5.16
Hydrophobic C-term E 740 - G.H3 T 279 G.H3.11
Aromatic ICL3 Y 613 - G.H5 F 361 G.H5.06
Hydrophobic ICL3 Y 613 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 Y 613 - G.H5 F 361 G.H5.06
Hydrophobic TM3 R 519 3x50 G.H5 L 380 G.H5.25
Van-der-waals TM3 R 519 3x50 G.H5 L 380 G.H5.25
Hydrophobic C-term L 764 - H.HA R 106 H.HA.20
Van-der-waals C-term L 764 - H.HA R 106 H.HA.20
Polar ICL2 D 530 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 D 530 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 D 530 34x54 G.hns1 R 56 G.hns1.03
Ionic C-term D 737 - G.H3 K 284 G.H3.16
Polar C-term D 737 - G.H3 K 284 G.H3.16
Van-der-waals C-term D 737 - G.H3 K 284 G.H3.16
Hydrophobic ICL3 Y 613 - G.H5 H 364 G.H5.09
Hydrophobic ICL2 A 526 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 A 526 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 M 527 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 M 527 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM5 V 608 5x65 G.H5 L 371 G.H5.16
Hydrophobic ICL3 Y 613 - G.S6 F 347 G.S6.02
Hydrophobic C-term L 741 - G.H2 W 238 G.H2.07
Hydrophobic C-term L 741 - G.H3 T 279 G.H3.11
Hydrophobic C-term I 755 - G.s4h3 R 266 G.s4h3.13
Van-der-waals C-term I 755 - G.s4h3 R 266 G.s4h3.13
Hydrophobic C-term L 741 - G.H3 I 280 G.H3.12
Hydrophobic TM6 I 622 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 I 622 6x33 G.H5 M 379 G.H5.24
Polar C-term T 762 - H.HA D 110 H.HA.24
Hydrophobic C-term T 762 - H.HA D 110 H.HA.24
Van-der-waals C-term T 762 - H.HA D 110 H.HA.24
Hydrophobic ICL2 M 527 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 M 527 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM3 I 523 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 523 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 R 528 34x52 G.S3 I 221 G.S3.01
Hydrophobic TM5 V 608 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM3 A 522 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 522 3x53 G.H5 I 378 G.H5.23
Polar C-term Y 759 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term Y 759 - G.s4h3 R 265 G.s4h3.12
Polar TM6 R 625 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM6 R 625 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 R 625 6x36 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 529 34x53 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 L 529 34x53 G.hns1 R 56 G.hns1.03
Polar H8 K 683 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 K 683 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 683 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM6 M 626 6x37 G.H5 M 379 G.H5.24
Van-der-waals TM6 M 626 6x37 G.H5 M 379 G.H5.24
Polar TM6 R 625 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 R 625 6x36 G.H5 L 380 G.H5.25
Hydrophobic ICL3 Y 613 - G.H5 A 365 G.H5.10
Hydrophobic TM5 T 607 5x64 G.H5 L 371 G.H5.16
Hydrophobic C-term L 741 - G.H3 N 283 G.H3.15
Van-der-waals C-term L 741 - G.H3 N 283 G.H3.15
Polar ICL3 Q 612 - G.H5 D 368 G.H5.13
Polar C-term D 737 - G.H3 N 283 G.H3.15
Hydrophobic C-term I 742 - G.H2 Q 236 G.H2.05
Polar C-term Y 759 - H.HA K 114 H.HA.28
Hydrophobic C-term Y 759 - H.HA K 114 H.HA.28
Van-der-waals C-term Y 759 - H.HA K 114 H.HA.28
Hydrophobic ICL2 M 527 34x51 G.S3 F 223 G.S3.03
Van-der-waals ICL2 M 527 34x51 G.S3 F 223 G.S3.03
Hydrophobic ICL2 M 527 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM3 I 523 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM2 P 449 2x39 G.H5 I 378 G.H5.23
Hydrophobic C-term V 738 - G.H3 L 285 G.H3.17
Hydrophobic C-term L 764 - H.HA V 107 H.HA.21
Hydrophobic C-term Q 761 - H.HA K 114 H.HA.28
Van-der-waals C-term Q 761 - H.HA K 114 H.HA.28
Hydrophobic C-term L 741 - G.h2s4 F 242 G.h2s4.01
Hydrophobic H8 T 682 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 T 682 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 529 34x53 G.H5 I 370 G.H5.15
Polar C-term T 762 - H.HA K 114 H.HA.28
Hydrophobic C-term T 762 - H.HA K 114 H.HA.28
Van-der-waals C-term T 762 - H.HA K 114 H.HA.28
Polar TM3 A 522 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 522 3x53 G.H5 N 374 G.H5.19
Polar ICL3 Q 612 - G.H5 H 364 G.H5.09
Hydrophobic ICL3 Q 612 - G.H5 H 364 G.H5.09
Van-der-waals ICL3 Q 612 - G.H5 H 364 G.H5.09
Polar TM3 R 519 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 519 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 519 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 M 527 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 M 527 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 L 529 34x53 G.hns1 R 55 G.hns1.02
Hydrophobic TM4 R 534 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 R 534 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 I 622 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM6 R 625 6x36 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 625 6x36 G.H5 Q 381 G.H5.26
Hydrophobic C-term V 763 - G.s4h3 M 262 G.s4h3.09
Hydrophobic TM7 Y 678 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 678 7x53 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 529 34x53 G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 L 529 34x53 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 529 34x53 G.S1 V 58 G.S1.02
Polar TM6 K 618 6x29 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 K 618 6x29 G.h4s6 S 343 G.h4s6.12
Hydrophobic C-term T 762 - H.HA A 111 H.HA.25
Hydrophobic C-term V 763 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term V 763 - G.s4h3 R 265 G.s4h3.12
Hydrophobic ICL2 M 527 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 M 527 34x51 G.H5 K 367 G.H5.12