G15 -
TSH receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 82.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL3 | Y | 613 | - | G.H5 | A | 365 | G.H5.17 |
Van-der-waals | ICL3 | Y | 613 | - | G.H5 | A | 365 | G.H5.17 |
Polar | C-term | I | 742 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | I | 742 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | I | 742 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | TM3 | A | 522 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | A | 522 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | I | 742 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | C-term | Y | 739 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | Y | 739 | - | G.H2 | I | 220 | G.H2.08 |
Polar | C-term | S | 745 | - | G.H3 | L | 257 | G.H3.08 |
Hydrophobic | C-term | S | 745 | - | G.H3 | L | 257 | G.H3.08 |
Van-der-waals | C-term | S | 745 | - | G.H3 | L | 257 | G.H3.08 |
Ionic | C-term | E | 743 | - | G.H2 | K | 217 | G.H2.05 |
Polar | C-term | E | 743 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | E | 743 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | E | 743 | - | G.H2 | K | 217 | G.H2.05 |
Polar | ICL3 | Y | 613 | - | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | ICL3 | Y | 613 | - | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | ICL3 | Y | 613 | - | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM3 | I | 523 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Ionic | C-term | H | 746 | - | G.s4h3 | E | 248 | G.s4h3.14 |
Hydrophobic | C-term | H | 746 | - | G.s4h3 | E | 248 | G.s4h3.14 |
Van-der-waals | C-term | H | 746 | - | G.s4h3 | E | 248 | G.s4h3.14 |
Polar | ICL3 | Q | 612 | - | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | ICL3 | Q | 612 | - | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | ICL3 | Q | 612 | - | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | ICL2 | L | 529 | 34x53 | G.S1 | E | 42 | G.S1.01 |
Hydrophobic | C-term | I | 742 | - | G.H3 | L | 257 | G.H3.08 |
Hydrophobic | TM3 | I | 523 | 3x54 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | I | 523 | 3x54 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | I | 742 | - | G.H3 | T | 260 | G.H3.11 |
Hydrophobic | C-term | I | 742 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | C-term | M | 735 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | M | 735 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | C-term | E | 743 | - | G.H2 | K | 213 | G.H2.01 |
Van-der-waals | C-term | E | 743 | - | G.H2 | K | 213 | G.H2.01 |
Polar | C-term | I | 755 | - | G.H4 | R | 318 | G.H4.17 |
Hydrophobic | C-term | I | 755 | - | G.H4 | R | 318 | G.H4.17 |
Van-der-waals | C-term | I | 755 | - | G.H4 | R | 318 | G.H4.17 |
Polar | C-term | K | 751 | - | G.H3 | G | 259 | G.H3.10 |
Van-der-waals | C-term | K | 751 | - | G.H3 | G | 259 | G.H3.10 |
Hydrophobic | ICL3 | Y | 613 | - | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | ICL3 | Y | 613 | - | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM6 | I | 622 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL2 | M | 527 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | M | 527 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Polar | C-term | Q | 754 | - | G.h4s6 | G | 322 | G.h4s6.04 |
Hydrophobic | C-term | Q | 754 | - | G.h4s6 | G | 322 | G.h4s6.04 |
Ionic | C-term | K | 751 | - | G.H3 | E | 263 | G.H3.14 |
Polar | C-term | K | 751 | - | G.H3 | E | 263 | G.H3.14 |
Hydrophobic | C-term | K | 751 | - | G.H3 | E | 263 | G.H3.14 |
Van-der-waals | C-term | K | 751 | - | G.H3 | E | 263 | G.H3.14 |
Polar | TM3 | E | 518 | 3x49 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | E | 518 | 3x49 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM5 | V | 608 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Polar | TM6 | I | 622 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | I | 622 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | I | 622 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Aromatic | C-term | Y | 759 | - | G.H4 | F | 311 | G.H4.10 |
Hydrophobic | C-term | Y | 759 | - | G.H4 | F | 311 | G.H4.10 |
Van-der-waals | C-term | Y | 759 | - | G.H4 | F | 311 | G.H4.10 |
Hydrophobic | ICL2 | M | 527 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | M | 527 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Ionic | C-term | E | 758 | - | G.H4 | R | 318 | G.H4.17 |
Hydrophobic | C-term | E | 758 | - | G.H4 | R | 318 | G.H4.17 |
Van-der-waals | C-term | E | 758 | - | G.H4 | R | 318 | G.H4.17 |
Hydrophobic | ICL2 | M | 527 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | M | 527 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | TM6 | L | 629 | 6x40 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | I | 742 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Polar | C-term | S | 745 | - | G.H3 | E | 253 | G.H3.04 |
Hydrophobic | C-term | I | 755 | - | G.H3 | L | 255 | G.H3.06 |
Van-der-waals | C-term | I | 755 | - | G.H3 | L | 255 | G.H3.06 |
Polar | ICL1 | N | 447 | - | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | ICL1 | N | 447 | - | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | ICL2 | L | 529 | 34x53 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | L | 529 | 34x53 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | C-term | S | 745 | - | G.H3 | A | 256 | G.H3.07 |
Van-der-waals | C-term | S | 745 | - | G.H3 | A | 256 | G.H3.07 |
Hydrophobic | C-term | I | 755 | - | G.H4 | M | 315 | G.H4.14 |
Polar | ICL2 | M | 527 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | ICL2 | M | 527 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | M | 527 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM6 | K | 621 | 6x32 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | TM6 | K | 621 | 6x32 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | TM6 | R | 625 | 6x36 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | H8 | T | 682 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | L | 747 | - | G.H3 | K | 252 | G.H3.03 |
Van-der-waals | C-term | L | 747 | - | G.H3 | K | 252 | G.H3.03 |
Hydrophobic | ICL2 | M | 527 | 34x51 | G.H5 | V | 359 | G.H5.11 |
Hydrophobic | C-term | P | 713 | - | G.h2s4 | E | 224 | G.h2s4.02 |
Polar | TM6 | R | 625 | 6x36 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | R | 625 | 6x36 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | R | 625 | 6x36 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | V | 738 | - | G.H3 | L | 264 | G.H3.15 |
Van-der-waals | C-term | V | 738 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | C-term | S | 745 | - | G.H3 | T | 260 | G.H3.11 |
Hydrophobic | C-term | Y | 759 | - | G.H4 | D | 314 | G.H4.13 |
Hydrophobic | C-term | Y | 739 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | Y | 739 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | ICL2 | A | 526 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | C-term | L | 747 | - | G.H3 | L | 255 | G.H3.06 |
Polar | TM6 | K | 618 | 6x29 | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | C-term | Y | 739 | - | G.H2 | H | 221 | G.H2.09 |
Polar | TM6 | R | 625 | 6x36 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | R | 625 | 6x36 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | R | 625 | 6x36 | G.H5 | L | 374 | G.H5.26 |
Polar | TM6 | R | 625 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | R | 625 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | R | 625 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | Y | 759 | - | G.H4 | R | 318 | G.H4.17 |
Van-der-waals | C-term | Y | 759 | - | G.H4 | R | 318 | G.H4.17 |
Hydrophobic | TM6 | M | 626 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | K | 751 | - | G.h4s6 | M | 319 | G.h4s6.01 |
Hydrophobic | C-term | V | 738 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | C-term | I | 755 | - | G.h4s6 | M | 319 | G.h4s6.01 |
Polar | C-term | S | 745 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | C-term | L | 747 | - | G.h4s6 | M | 319 | G.h4s6.01 |
Hydrophobic | ICL2 | L | 529 | 34x53 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | ICL3 | Y | 613 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | ICL3 | Y | 613 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | TM7 | F | 681 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM7 | F | 681 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | F | 681 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM3 | I | 523 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Polar | TM3 | R | 519 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | R | 519 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | C-term | I | 742 | - | G.H2 | W | 219 | G.H2.07 |
Hydrophobic | C-term | L | 747 | - | G.H3 | A | 256 | G.H3.07 |
Van-der-waals | C-term | L | 747 | - | G.H3 | A | 256 | G.H3.07 |
Polar | TM3 | R | 519 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | R | 519 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | R | 519 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | R | 528 | 34x52 | G.s2s3 | K | 201 | G.s2s3.02 |
Hydrophobic | C-term | H | 746 | - | G.H3 | A | 256 | G.H3.07 |
Van-der-waals | C-term | H | 746 | - | G.H3 | A | 256 | G.H3.07 |
Hydrophobic | C-term | V | 738 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | TM3 | I | 523 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | I | 523 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Polar | TM6 | K | 621 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | K | 621 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | K | 621 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Polar | C-term | L | 741 | - | G.H3 | T | 260 | G.H3.11 |
Hydrophobic | C-term | L | 741 | - | G.H3 | T | 260 | G.H3.11 |
Van-der-waals | C-term | L | 741 | - | G.H3 | T | 260 | G.H3.11 |
Hydrophobic | C-term | M | 735 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | ICL2 | A | 526 | 34x50 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | ICL2 | L | 529 | 34x53 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | L | 529 | 34x53 | G.hns1 | R | 40 | G.hns1.02 |