Ggust -
TSH receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | L | 741 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Polar | TM6 | R | 625 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Polar | TM3 | R | 519 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 519 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 519 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Ionic | ICL2 | D | 530 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL2 | D | 530 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | D | 530 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | D | 530 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | C-term | V | 738 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | C-term | V | 738 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | TM5 | V | 608 | 5x65 | G.H5 | I | 344 | G.H5.16 |
Polar | C-term | D | 737 | - | G.H3 | H | 256 | G.H3.15 |
Polar | C-term | Y | 739 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | ICL2 | A | 526 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | A | 526 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | C-term | I | 742 | - | G.H2 | K | 209 | G.H2.05 |
Van-der-waals | C-term | I | 742 | - | G.H2 | K | 209 | G.H2.05 |
Ionic | H8 | K | 683 | 8x48 | G.h4s6 | D | 316 | G.h4s6.10 |
Polar | H8 | K | 683 | 8x48 | G.h4s6 | D | 316 | G.h4s6.10 |
Van-der-waals | H8 | K | 683 | 8x48 | G.h4s6 | D | 316 | G.h4s6.10 |
Aromatic | ICL3 | Y | 613 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | ICL3 | Y | 613 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | Y | 613 | - | G.S6 | Y | 320 | G.S6.02 |
Ionic | ICL2 | R | 528 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | ICL2 | R | 528 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Ionic | TM6 | K | 618 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | K | 618 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | K | 618 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | K | 618 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM3 | I | 523 | 3x54 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | M | 527 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM3 | R | 519 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | L | 529 | 34x53 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | L | 529 | 34x53 | G.hns1 | A | 31 | G.hns1.02 |
Polar | ICL3 | Y | 613 | - | G.H5 | A | 338 | G.H5.10 |
Hydrophobic | ICL3 | Y | 613 | - | G.H5 | A | 338 | G.H5.10 |
Hydrophobic | ICL3 | Y | 613 | - | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | TM5 | I | 604 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | Y | 601 | 5x58 | G.H5 | L | 353 | G.H5.25 |
Polar | TM3 | A | 522 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 522 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Polar | TM6 | K | 618 | 6x29 | G.h4s6 | E | 315 | G.h4s6.09 |
Hydrophobic | TM6 | K | 618 | 6x29 | G.h4s6 | E | 315 | G.h4s6.09 |
Van-der-waals | TM6 | K | 618 | 6x29 | G.h4s6 | E | 315 | G.h4s6.09 |
Polar | C-term | L | 741 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | C-term | L | 741 | - | G.H3 | S | 252 | G.H3.11 |
Van-der-waals | C-term | L | 741 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | C-term | N | 744 | - | G.H3 | H | 248 | G.H3.07 |
Polar | ICL3 | Y | 613 | - | G.S6 | H | 322 | G.S6.04 |
Aromatic | ICL3 | Y | 613 | - | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | ICL3 | Y | 613 | - | G.S6 | H | 322 | G.S6.04 |
Van-der-waals | ICL3 | Y | 613 | - | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | C-term | L | 741 | - | G.H3 | I | 253 | G.H3.12 |
Hydrophobic | TM6 | I | 622 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM3 | I | 523 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | M | 527 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | M | 527 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | TM6 | L | 629 | 6x40 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | L | 629 | 6x40 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | M | 527 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | M | 527 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | ICL2 | L | 529 | 34x53 | G.H5 | I | 343 | G.H5.15 |
Ionic | C-term | D | 737 | - | G.H3 | K | 257 | G.H3.16 |
Polar | C-term | D | 737 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | C-term | D | 737 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | D | 737 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | ICL2 | M | 527 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | M | 527 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | TM6 | K | 621 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM5 | V | 608 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | V | 608 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | L | 741 | - | G.H3 | H | 256 | G.H3.15 |
Van-der-waals | C-term | L | 741 | - | G.H3 | H | 256 | G.H3.15 |
Ionic | TM4 | R | 534 | 4x38 | G.HN | E | 28 | G.HN.52 |
Polar | TM4 | R | 534 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | R | 534 | 4x38 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | R | 534 | 4x38 | G.HN | E | 28 | G.HN.52 |
Polar | ICL3 | Y | 613 | - | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | TM6 | I | 622 | 6x33 | G.H5 | F | 354 | G.H5.26 |
Polar | TM6 | R | 625 | 6x36 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | R | 625 | 6x36 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 625 | 6x36 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | ICL2 | A | 526 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Polar | TM6 | K | 618 | 6x29 | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | TM6 | K | 618 | 6x29 | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | TM6 | K | 618 | 6x29 | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | TM6 | R | 625 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | R | 625 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | H8 | T | 682 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | M | 626 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | P | 713 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Van-der-waals | C-term | P | 713 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | C-term | I | 742 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | TM3 | I | 523 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 523 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | K | 618 | 6x29 | G.H5 | F | 354 | G.H5.26 |