G12 - UT receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 72.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 A 249 6x26 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 P 155 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 155 34x50 G.H5 I 370 G.H5.15
Polar C-term S 369 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term S 369 - G.s4h3 R 265 G.s4h3.12
Hydrophobic TM2 V 90 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 V 90 2x43 G.H5 L 380 G.H5.25
Hydrophobic TM3 V 152 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 152 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM3 E 147 3x49 G.H5 I 378 G.H5.23
Polar H8 Y 322 8x50 G.H5 D 377 G.H5.22
Polar TM3 L 153 3x55 G.H5 K 367 G.H5.12
Hydrophobic TM3 L 153 3x55 G.H5 K 367 G.H5.12
Van-der-waals TM3 L 153 3x55 G.H5 K 367 G.H5.12
Hydrophobic H8 R 329 8x57 G.h3s5 F 287 G.h3s5.01
Van-der-waals H8 R 329 8x57 G.h3s5 F 287 G.h3s5.01
Polar H8 T 319 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 T 319 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 T 319 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 V 159 34x54 G.H5 N 374 G.H5.19
Van-der-waals ICL2 V 159 34x54 G.H5 N 374 G.H5.19
Hydrophobic ICL2 V 159 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 V 159 34x54 G.H5 I 370 G.H5.15
Polar H8 H 325 8x53 G.H5 K 376 G.H5.21
Hydrophobic H8 H 325 8x53 G.H5 K 376 G.H5.21
Van-der-waals H8 H 325 8x53 G.H5 K 376 G.H5.21
Polar TM2 M 86 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM2 M 86 2x39 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 256 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 256 6x33 G.H5 M 379 G.H5.24
Polar TM3 R 148 3x50 G.H5 M 379 G.H5.24
Hydrophobic TM3 R 148 3x50 G.H5 M 379 G.H5.24
Van-der-waals TM3 R 148 3x50 G.H5 M 379 G.H5.24
Polar TM3 R 148 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 148 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 148 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM6 A 249 6x26 G.S6 F 347 G.S6.02
Hydrophobic ICL2 P 155 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 155 34x50 G.H5 K 367 G.H5.12
Polar ICL2 T 158 34x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 T 158 34x53 G.H5 N 374 G.H5.19
Van-der-waals ICL2 T 158 34x53 G.H5 N 374 G.H5.19
Hydrophobic TM7 L 318 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 L 318 7x56 G.H5 M 379 G.H5.24
Hydrophobic TM2 M 86 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 M 86 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM3 V 152 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 152 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM6 G 253 6x30 G.H5 L 375 G.H5.20
Van-der-waals TM6 G 253 6x30 G.H5 L 375 G.H5.20
Hydrophobic TM3 A 151 3x53 G.H5 L 371 G.H5.16
Van-der-waals TM3 A 151 3x53 G.H5 L 371 G.H5.16
Hydrophobic C-term L 370 - H.HA K 114 H.HA.28
Van-der-waals C-term L 370 - H.HA K 114 H.HA.28
Polar ICL2 P 155 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 155 34x50 G.H5 N 374 G.H5.19
Ionic TM4 K 163 4x39 G.H5 D 377 G.H5.22
Hydrophobic ICL2 L 156 34x51 G.H5 V 366 G.H5.11
Van-der-waals TM7 L 318 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM4 P 162 4x38 G.HN R 52 G.HN.52
Hydrophobic TM6 R 251 6x28 G.H5 L 371 G.H5.16
Van-der-waals TM6 R 251 6x28 G.H5 L 371 G.H5.16
Polar H8 G 328 8x56 G.h4s6 N 341 G.h4s6.10
Hydrophobic TM6 A 256 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM3 A 151 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL1 L 80 12x48 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 156 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 156 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM6 R 251 6x28 G.H5 Q 372 G.H5.17
Hydrophobic H8 N 321 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 321 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM1 T 76 1x57 G.H5 L 380 G.H5.25
Hydrophobic TM6 P 252 6x29 G.H5 K 376 G.H5.21
Polar ICL2 Q 160 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 Q 160 34x55 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 Q 160 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic TM2 Y 87 2x40 G.H5 L 380 G.H5.25
Hydrophobic TM2 A 84 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 A 84 2x37 G.H5 D 377 G.H5.22
Polar H8 R 329 8x57 G.h3s5 N 288 G.h3s5.02
Hydrophobic H8 R 329 8x57 G.h3s5 N 288 G.h3s5.02
Van-der-waals H8 R 329 8x57 G.h3s5 N 288 G.h3s5.02
Hydrophobic TM6 L 259 6x36 G.H5 M 379 G.H5.24
Polar TM2 S 85 2x38 G.H5 I 378 G.H5.23
Van-der-waals TM2 S 85 2x38 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 156 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 156 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 L 156 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 P 155 34x50 G.H5 L 371 G.H5.16
Van-der-waals ICL2 P 155 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM2 A 84 2x37 G.H5 L 380 G.H5.25
Van-der-waals TM2 A 84 2x37 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 156 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 156 34x51 G.S1 V 58 G.S1.02
Polar H8 Y 322 8x50 G.H5 L 380 G.H5.25
Hydrophobic H8 Y 322 8x50 G.H5 L 380 G.H5.25
Van-der-waals H8 Y 322 8x50 G.H5 L 380 G.H5.25
Ionic TM6 R 251 6x28 G.H5 D 368 G.H5.13
Polar TM6 R 251 6x28 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 251 6x28 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 251 6x28 G.H5 D 368 G.H5.13
Hydrophobic ICL2 V 159 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 V 159 34x54 G.hns1 R 55 G.hns1.02
Polar TM2 S 85 2x38 G.H5 D 377 G.H5.22
Hydrophobic TM2 S 85 2x38 G.H5 D 377 G.H5.22
Van-der-waals TM2 S 85 2x38 G.H5 D 377 G.H5.22
Hydrophobic ICL2 L 156 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 156 34x51 G.S3 I 221 G.S3.01
Polar ICL2 Q 160 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 Q 160 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 Q 160 34x55 G.hns1 R 56 G.hns1.03
Polar C-term D 368 - H.HA K 114 H.HA.28
Van-der-waals C-term D 368 - H.HA K 114 H.HA.28
Hydrophobic C-term L 372 - H.HA K 114 H.HA.28
Hydrophobic TM6 P 252 6x29 G.H5 Q 372 G.H5.17
Hydrophobic H8 Y 322 8x50 G.H5 Q 381 G.H5.26
Van-der-waals H8 Y 322 8x50 G.H5 Q 381 G.H5.26
Hydrophobic TM3 A 151 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 151 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM6 R 255 6x32 G.H5 M 379 G.H5.24
Polar C-term S 369 - H.HA K 114 H.HA.28