G13 -
UT receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 74.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | L | 372 | - | H.HA | L | 106 | H.HA.29 |
Van-der-waals | C-term | L | 372 | - | H.HA | L | 106 | H.HA.29 |
Hydrophobic | ICL1 | L | 80 | 12x48 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | ICL1 | L | 80 | 12x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | P | 155 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | P | 155 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | H8 | T | 319 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | T | 319 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | L | 156 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | L | 156 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Polar | ICL2 | P | 155 | 34x50 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM2 | V | 90 | 2x43 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | V | 90 | 2x43 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | P | 155 | 34x50 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL2 | L | 156 | 34x51 | G.H5 | V | 362 | G.H5.11 |
Ionic | TM6 | R | 251 | 6x28 | G.H5 | D | 364 | G.H5.13 |
Polar | TM6 | R | 251 | 6x28 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM6 | R | 251 | 6x28 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM6 | R | 251 | 6x28 | G.H5 | D | 364 | G.H5.13 |
Polar | TM3 | L | 153 | 3x55 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | TM3 | L | 153 | 3x55 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | TM3 | L | 153 | 3x55 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | ICL2 | L | 156 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Van-der-waals | ICL2 | L | 156 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | TM3 | A | 151 | 3x53 | G.H5 | L | 367 | G.H5.16 |
Polar | ICL2 | T | 158 | 34x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | ICL2 | T | 158 | 34x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM7 | L | 318 | 7x56 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM7 | L | 318 | 7x56 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | A | 256 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | A | 256 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | H8 | T | 319 | 8x47 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM3 | A | 151 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | A | 151 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Polar | TM3 | R | 148 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | R | 148 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | R | 148 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM2 | Y | 87 | 2x40 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM2 | A | 84 | 2x37 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | A | 84 | 2x37 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | E | 147 | 3x49 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM6 | P | 252 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | P | 252 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Polar | C-term | S | 369 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | S | 369 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | L | 370 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | L | 370 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | TM3 | V | 152 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | V | 152 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Polar | H8 | T | 319 | 8x47 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | H8 | T | 319 | 8x47 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | H8 | T | 319 | 8x47 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | V | 159 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | V | 159 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | C-term | L | 372 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | L | 372 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | ICL2 | P | 155 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | P | 155 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | C-term | L | 370 | - | H.HA | A | 102 | H.HA.25 |
Hydrophobic | TM6 | G | 253 | 6x30 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM6 | G | 253 | 6x30 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM2 | M | 86 | 2x39 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM6 | A | 256 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Polar | C-term | L | 370 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | C-term | L | 370 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | L | 370 | - | H.HA | D | 101 | H.HA.24 |
Polar | C-term | V | 371 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | V | 371 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | L | 370 | - | H.hdhe | F | 168 | H.hdhe.01 |
Hydrophobic | TM7 | L | 318 | 7x56 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | C-term | L | 370 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | L | 370 | - | H.HA | K | 105 | H.HA.28 |
Polar | TM2 | S | 85 | 2x38 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM2 | S | 85 | 2x38 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | TM2 | S | 85 | 2x38 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | ICL2 | L | 156 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | L | 156 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | ICL2 | V | 159 | 34x54 | G.hns1 | R | 47 | G.hns1.03 |
Polar | H8 | N | 321 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | N | 321 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | N | 321 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Polar | C-term | A | 373 | - | H.HD | E | 167 | H.HD.12 |
Hydrophobic | C-term | A | 373 | - | H.HD | E | 167 | H.HD.12 |
Van-der-waals | C-term | A | 373 | - | H.HD | E | 167 | H.HD.12 |
Hydrophobic | ICL2 | L | 156 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | TM2 | A | 84 | 2x37 | G.H5 | Q | 373 | G.H5.22 |
Polar | ICL2 | Q | 160 | 34x55 | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | TM6 | R | 248 | 6x25 | G.H4 | R | 331 | G.H4.16 |
Hydrophobic | ICL2 | L | 156 | 34x51 | G.S1 | V | 49 | G.S1.02 |
Hydrophobic | C-term | L | 370 | - | H.HA | V | 98 | H.HA.21 |
Van-der-waals | C-term | L | 370 | - | H.HA | V | 98 | H.HA.21 |
Polar | TM3 | A | 151 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | A | 151 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | A | 151 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Polar | ICL2 | Q | 160 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | Q | 160 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 160 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM6 | P | 252 | 6x29 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | P | 252 | 6x29 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | R | 255 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | V | 152 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | V | 152 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL2 | V | 159 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | V | 159 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | C-term | S | 369 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | S | 369 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | TM2 | M | 86 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM2 | M | 86 | 2x39 | G.H5 | L | 374 | G.H5.23 |