Gt1 - UT receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 13.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term L 370 - G.H2 K 205 G.H2.05
Van-der-waals C-term L 370 - G.H2 K 205 G.H2.05
Polar TM5 S 241 5x68 G.H5 D 337 G.H5.13
Hydrophobic TM5 S 241 5x68 G.H5 D 337 G.H5.13
Van-der-waals TM5 S 241 5x68 G.H5 D 337 G.H5.13
Hydrophobic ICL2 V 159 34x54 G.H5 I 339 G.H5.15
Hydrophobic TM5 Y 231 5x58 G.H5 L 349 G.H5.25
Polar TM3 R 148 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM3 R 148 3x50 G.H5 C 347 G.H5.23
Van-der-waals TM3 R 148 3x50 G.H5 C 347 G.H5.23
Polar TM3 A 151 3x53 G.H5 N 343 G.H5.19
Hydrophobic TM3 A 151 3x53 G.H5 N 343 G.H5.19
Van-der-waals TM3 A 151 3x53 G.H5 N 343 G.H5.19
Hydrophobic TM5 Y 238 5x65 G.H5 L 344 G.H5.20
Van-der-waals TM5 Y 238 5x65 G.H5 L 344 G.H5.20
Hydrophobic H8 R 320 8x48 G.H5 K 345 G.H5.21
Hydrophobic C-term L 372 - G.H2 I 208 G.H2.08
Aromatic TM6 F 246 6x23 G.S6 Y 316 G.S6.02
Hydrophobic TM6 F 246 6x23 G.S6 Y 316 G.S6.02
Van-der-waals TM6 F 246 6x23 G.S6 Y 316 G.S6.02
Polar TM2 S 85 2x38 G.H5 D 346 G.H5.22
Hydrophobic TM2 S 85 2x38 G.H5 D 346 G.H5.22
Van-der-waals TM2 S 85 2x38 G.H5 D 346 G.H5.22
Hydrophobic TM6 V 260 6x37 G.H5 L 349 G.H5.25
Van-der-waals TM6 V 260 6x37 G.H5 L 349 G.H5.25
Van-der-waals ICL1 V 83 12x51 G.H5 D 346 G.H5.22
Polar H8 R 320 8x48 G.H5 F 350 G.H5.26
Hydrophobic H8 R 320 8x48 G.H5 F 350 G.H5.26
Van-der-waals H8 R 320 8x48 G.H5 F 350 G.H5.26
Hydrophobic ICL2 L 156 34x51 G.H5 I 339 G.H5.15
Hydrophobic TM5 Q 242 5x69 G.H5 K 341 G.H5.17
Van-der-waals TM5 Q 242 5x69 G.H5 K 341 G.H5.17
Hydrophobic H8 T 319 8x47 G.H5 G 348 G.H5.24
Van-der-waals H8 T 319 8x47 G.H5 G 348 G.H5.24
Hydrophobic ICL2 V 159 34x54 G.hns1 A 27 G.hns1.02
Van-der-waals ICL2 V 159 34x54 G.hns1 A 27 G.hns1.02
Polar C-term A 373 - G.H3 R 253 G.H3.16
Polar ICL3 S 245 - G.H5 D 337 G.H5.13
Hydrophobic ICL3 S 245 - G.H5 D 337 G.H5.13
Hydrophobic ICL2 P 155 34x50 G.H5 T 336 G.H5.12
Hydrophobic TM6 I 263 6x40 G.H5 L 349 G.H5.25
Hydrophobic TM5 L 234 5x61 G.H5 L 344 G.H5.20
Polar H8 N 321 8x49 G.H5 D 346 G.H5.22
Polar TM5 Q 242 5x69 G.H5 D 337 G.H5.13
Van-der-waals TM5 Q 242 5x69 G.H5 D 337 G.H5.13
Polar H8 N 321 8x49 G.H5 K 345 G.H5.21
Hydrophobic ICL2 P 155 34x50 G.H5 I 340 G.H5.16
Hydrophobic TM3 V 152 3x54 G.H5 L 344 G.H5.20
Van-der-waals TM3 V 152 3x54 G.H5 L 344 G.H5.20
Hydrophobic TM6 P 252 6x29 G.H5 F 350 G.H5.26
Van-der-waals TM6 P 252 6x29 G.H5 F 350 G.H5.26
Hydrophobic TM5 Y 238 5x65 G.H5 F 350 G.H5.26
Hydrophobic C-term L 372 - G.H3 H 252 G.H3.15
Van-der-waals C-term L 372 - G.H3 H 252 G.H3.15
Aromatic TM6 F 246 6x23 G.H5 F 330 G.H5.06
Hydrophobic TM6 F 246 6x23 G.H5 F 330 G.H5.06
Van-der-waals TM6 F 246 6x23 G.H5 F 330 G.H5.06
Hydrophobic ICL3 S 245 - G.S6 Y 316 G.S6.02
Van-der-waals ICL3 S 245 - G.S6 Y 316 G.S6.02
Hydrophobic TM5 Y 238 5x65 G.H5 I 340 G.H5.16
Hydrophobic TM6 A 256 6x33 G.H5 L 349 G.H5.25
Van-der-waals TM6 A 256 6x33 G.H5 L 349 G.H5.25
Hydrophobic ICL2 L 156 34x51 G.s2s3 D 189 G.s2s3.02
Polar ICL2 T 158 34x53 G.H5 N 343 G.H5.19
Van-der-waals ICL2 T 158 34x53 G.H5 N 343 G.H5.19
Hydrophobic TM6 A 256 6x33 G.H5 F 350 G.H5.26
Hydrophobic TM3 A 151 3x53 G.H5 C 347 G.H5.23
Hydrophobic TM2 M 86 2x39 G.H5 C 347 G.H5.23
Van-der-waals TM2 M 86 2x39 G.H5 C 347 G.H5.23
Hydrophobic TM3 V 152 3x54 G.H5 I 340 G.H5.16
Polar ICL2 Q 160 34x55 G.hns1 R 28 G.hns1.03
Hydrophobic ICL2 Q 160 34x55 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 Q 160 34x55 G.hns1 R 28 G.hns1.03
Ionic H8 D 324 8x52 G.H5 K 345 G.H5.21
Polar H8 D 324 8x52 G.H5 K 345 G.H5.21
Hydrophobic H8 D 324 8x52 G.H5 K 345 G.H5.21
Van-der-waals H8 D 324 8x52 G.H5 K 345 G.H5.21
Hydrophobic ICL2 P 155 34x50 G.H5 I 339 G.H5.15
Van-der-waals ICL2 P 155 34x50 G.H5 I 339 G.H5.15
Van-der-waals ICL2 L 156 34x51 G.s2s3 K 188 G.s2s3.01
Polar ICL2 P 155 34x50 G.H5 N 343 G.H5.19
Van-der-waals ICL2 P 155 34x50 G.H5 N 343 G.H5.19
Hydrophobic TM5 L 234 5x61 G.H5 L 349 G.H5.25
Hydrophobic C-term L 370 - G.H2 R 204 G.H2.04
Hydrophobic TM3 R 148 3x50 G.H5 L 349 G.H5.25
Van-der-waals TM3 R 148 3x50 G.H5 L 349 G.H5.25
Hydrophobic TM6 L 259 6x36 G.H5 L 349 G.H5.25
Hydrophobic TM6 F 246 6x23 G.S6 S 317 G.S6.03
Van-der-waals TM6 F 246 6x23 G.S6 S 317 G.S6.03
Hydrophobic TM5 S 241 5x68 G.H5 I 340 G.H5.16
Hydrophobic TM4 P 162 4x38 G.HN K 20 G.HN.48
Van-der-waals TM4 P 162 4x38 G.HN K 20 G.HN.48
Hydrophobic TM6 R 255 6x32 G.H5 F 350 G.H5.26
Van-der-waals TM6 R 255 6x32 G.H5 F 350 G.H5.26
Hydrophobic ICL2 Q 160 34x55 G.HN E 24 G.HN.52
Hydrophobic TM6 A 249 6x26 G.h4s6 E 314 G.h4s6.12
Polar TM3 R 148 3x50 G.H5 G 348 G.H5.24
Hydrophobic TM5 Y 238 5x65 G.H5 K 341 G.H5.17
Hydrophobic ICL2 L 156 34x51 G.S3 L 190 G.S3.01
Van-der-waals ICL2 L 156 34x51 G.S3 L 190 G.S3.01