G12 - V1B receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 76.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 15.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 S 267 - G.h4s6 S 343 G.h4s6.12
Hydrophobic H8 N 342 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 342 8x47 G.H5 L 380 G.H5.25
Polar ICL2 Q 144 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 Q 144 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 Q 144 34x55 G.hns1 R 56 G.hns1.03
Aromatic ICL3 W 244 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 W 244 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 W 244 - G.S6 H 348 G.S6.03
Hydrophobic TM2 M 69 2x39 G.H5 L 380 G.H5.25
Van-der-waals TM2 M 69 2x39 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 140 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM2 M 69 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 M 69 2x39 G.H5 I 378 G.H5.23
Ionic TM5 K 233 5x72 G.H5 D 368 G.H5.13
Polar TM5 K 233 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 233 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 233 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM2 M 69 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM2 M 69 2x39 G.H5 D 377 G.H5.22
Hydrophobic ICL3 S 264 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 S 264 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL3 W 244 - G.H4 V 332 G.H4.12
Van-der-waals ICL3 W 244 - G.H4 V 332 G.H4.12
Hydrophobic ICL3 W 244 - G.S6 F 350 G.S6.05
Polar ICL3 S 264 - G.S6 L 346 G.S6.01
Hydrophobic ICL3 S 264 - G.S6 L 346 G.S6.01
Van-der-waals ICL3 S 264 - G.S6 L 346 G.S6.01
Hydrophobic TM4 P 146 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 P 146 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM7 F 341 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 341 7x56 G.H5 L 380 G.H5.25
Hydrophobic ICL3 W 244 - G.H4 R 329 G.H4.09
Polar ICL3 S 268 - G.H5 D 368 G.H5.13
Hydrophobic TM6 R 278 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 278 6x32 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 L 140 34x51 G.H5 I 370 G.H5.15
Polar TM6 R 278 6x32 G.H5 M 379 G.H5.24
Hydrophobic TM6 R 278 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 R 278 6x32 G.H5 M 379 G.H5.24
Hydrophobic TM3 V 136 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 136 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 143 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 143 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM5 I 226 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 I 226 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 139 34x50 G.H5 L 371 G.H5.16
Polar TM4 Q 148 4x40 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 V 136 3x54 G.H5 L 375 G.H5.20
Polar ICL3 S 267 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 S 267 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL3 P 263 - G.H4 D 336 G.H4.16
Hydrophobic TM6 I 272 6x26 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 140 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 140 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM4 Q 148 4x40 G.HN R 52 G.HN.52
Polar TM3 A 135 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 135 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 135 3x53 G.H5 N 374 G.H5.19
Polar ICL3 S 267 - G.h4s6 K 344 G.h4s6.19
Hydrophobic TM5 N 229 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 N 229 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM3 R 132 3x50 G.H5 I 378 G.H5.23
Polar ICL3 S 268 - G.H5 Q 372 G.H5.17
Hydrophobic ICL3 S 268 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 S 268 - G.H5 Q 372 G.H5.17
Hydrophobic ICL2 P 139 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 139 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 143 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 L 143 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 Q 144 34x55 G.S3 I 221 G.S3.01
Van-der-waals ICL2 Q 144 34x55 G.S3 I 221 G.S3.01
Polar ICL3 S 264 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 S 264 - G.S6 H 348 G.S6.03
Hydrophobic TM3 A 135 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM6 A 275 6x29 G.H5 L 375 G.H5.20
Polar H8 S 343 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 S 343 8x48 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 275 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 275 6x29 G.H5 M 379 G.H5.24
Polar ICL2 Q 144 34x55 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 Q 144 34x55 G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL3 S 268 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 L 140 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 140 34x51 G.H5 F 363 G.H5.08
Polar H8 H 344 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 H 344 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 H 344 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM4 P 146 4x38 G.hns1 R 56 G.hns1.03
Ionic TM5 E 225 5x64 G.H5 K 367 G.H5.12
Polar TM5 E 225 5x64 G.H5 K 367 G.H5.12
Hydrophobic ICL2 P 139 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 139 34x50 G.H5 K 367 G.H5.12
Polar TM5 N 229 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 N 229 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM3 V 136 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 136 3x54 G.H5 I 378 G.H5.23
Polar ICL2 L 143 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 L 143 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 L 143 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 R 274 6x28 G.H5 M 379 G.H5.24
Polar H8 H 344 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM2 S 67 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 S 67 2x37 G.H5 D 377 G.H5.22
Hydrophobic ICL2 L 143 34x54 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 143 34x54 G.S1 V 58 G.S1.02