G13 -
V1B receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | I | 222 | 5x61 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM4 | P | 146 | 4x38 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | L | 140 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Polar | C-term | T | 421 | - | H.HA | A | 102 | H.HA.25 |
Hydrophobic | C-term | T | 421 | - | H.HA | A | 102 | H.HA.25 |
Hydrophobic | ICL2 | L | 143 | 34x54 | G.h2s4 | T | 241 | G.h2s4.05 |
Hydrophobic | TM3 | V | 136 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM6 | T | 271 | 6x25 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM6 | A | 275 | 6x29 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | L | 140 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Van-der-waals | ICL2 | L | 140 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | ICL2 | P | 139 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | P | 139 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Polar | ICL2 | Q | 144 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | Q | 144 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 144 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Polar | C-term | F | 424 | - | H.HD | E | 167 | H.HD.12 |
Hydrophobic | C-term | F | 424 | - | H.HD | E | 167 | H.HD.12 |
Van-der-waals | C-term | F | 424 | - | H.HD | E | 167 | H.HD.12 |
Hydrophobic | ICL2 | L | 140 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | L | 140 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Polar | ICL2 | S | 142 | 34x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL2 | L | 140 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | TM6 | I | 272 | 6x26 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | L | 143 | 34x54 | G.S1 | V | 49 | G.S1.02 |
Polar | TM3 | A | 135 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | A | 135 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | A | 135 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Polar | TM4 | Q | 148 | 4x40 | G.HN | T | 43 | G.HN.52 |
Ionic | TM5 | E | 225 | 5x64 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | C-term | I | 423 | - | H.HD | E | 167 | H.HD.12 |
Van-der-waals | C-term | I | 423 | - | H.HD | E | 167 | H.HD.12 |
Hydrophobic | ICL2 | P | 139 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | P | 139 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | C-term | F | 424 | - | G.s4h3 | V | 255 | G.s4h3.07 |
Van-der-waals | C-term | F | 424 | - | G.s4h3 | V | 255 | G.s4h3.07 |
Polar | TM3 | R | 132 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | R | 132 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | I | 422 | - | H.hdhe | F | 168 | H.hdhe.01 |
Hydrophobic | ICL3 | W | 244 | - | G.H4 | K | 324 | G.H4.09 |
Hydrophobic | ICL3 | W | 244 | - | G.S6 | F | 346 | G.S6.05 |
Polar | ICL2 | Q | 144 | 34x55 | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ICL2 | Q | 144 | 34x55 | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | TM5 | N | 229 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | N | 229 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Polar | TM4 | Q | 148 | 4x40 | G.HN | S | 39 | G.HN.48 |
Hydrophobic | ICL3 | S | 268 | - | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | A | 275 | 6x29 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | C-term | T | 421 | - | H.hdhe | F | 168 | H.hdhe.01 |
Van-der-waals | C-term | T | 421 | - | H.hdhe | F | 168 | H.hdhe.01 |
Hydrophobic | ICL2 | L | 140 | 34x51 | G.H5 | V | 362 | G.H5.11 |
Polar | ICL2 | L | 143 | 34x54 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | L | 143 | 34x54 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | C-term | I | 423 | - | H.hdhe | F | 168 | H.hdhe.01 |
Hydrophobic | TM6 | T | 271 | 6x25 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM6 | T | 271 | 6x25 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | A | 135 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | A | 135 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | F | 424 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Van-der-waals | C-term | F | 424 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Hydrophobic | ICL3 | P | 263 | - | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | ICL3 | P | 263 | - | G.H4 | R | 331 | G.H4.16 |
Polar | C-term | T | 421 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | C-term | T | 421 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | T | 421 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | TM6 | M | 282 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM2 | M | 69 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM2 | M | 69 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Aromatic | ICL3 | W | 244 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | ICL3 | W | 244 | - | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | ICL3 | W | 244 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | C-term | F | 424 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | F | 424 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Polar | ICL2 | Q | 145 | 34x56 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | Q | 145 | 34x56 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 145 | 34x56 | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM6 | R | 278 | 6x32 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM6 | R | 278 | 6x32 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM6 | R | 278 | 6x32 | G.H5 | L | 376 | G.H5.25 |
Polar | C-term | T | 421 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | C-term | T | 421 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | T | 421 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | TM3 | V | 136 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | V | 136 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | C-term | E | 420 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | ICL3 | W | 244 | - | G.H4 | V | 327 | G.H4.12 |
Van-der-waals | ICL3 | W | 244 | - | G.H4 | V | 327 | G.H4.12 |
Hydrophobic | C-term | I | 422 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | I | 422 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | ICL2 | L | 143 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | L | 143 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | C-term | I | 423 | - | H.HA | L | 106 | H.HA.29 |
Van-der-waals | C-term | I | 423 | - | H.HA | L | 106 | H.HA.29 |
Ionic | C-term | D | 414 | - | G.hfs2 | K | 204 | G.hfs2.06 |
Polar | C-term | D | 414 | - | G.hfs2 | K | 204 | G.hfs2.06 |
Polar | C-term | E | 420 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | E | 420 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Polar | H8 | H | 344 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | H | 344 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | H | 344 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Polar | H8 | S | 343 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | S | 343 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | S | 343 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | C-term | F | 424 | - | H.hdhe | F | 168 | H.hdhe.01 |
Van-der-waals | C-term | F | 424 | - | H.hdhe | F | 168 | H.hdhe.01 |
Hydrophobic | ICL2 | L | 140 | 34x51 | G.S1 | V | 49 | G.S1.02 |
Hydrophobic | ICL3 | W | 244 | - | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | ICL3 | W | 244 | - | G.H4 | R | 331 | G.H4.16 |
Ionic | C-term | E | 416 | - | H.HA | K | 94 | H.HA.17 |
Polar | C-term | E | 416 | - | H.HA | K | 94 | H.HA.17 |
Hydrophobic | C-term | E | 416 | - | H.HA | K | 94 | H.HA.17 |
Van-der-waals | C-term | E | 416 | - | H.HA | K | 94 | H.HA.17 |
Hydrophobic | H8 | N | 342 | 8x47 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | N | 342 | 8x47 | G.H5 | Q | 377 | G.H5.26 |
Polar | TM6 | R | 278 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | R | 278 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | R | 278 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM5 | I | 226 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | I | 226 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Polar | TM6 | T | 271 | 6x25 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | T | 271 | 6x25 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | T | 271 | 6x25 | G.H5 | H | 368 | G.H5.17 |
Polar | C-term | E | 416 | - | H.HB | T | 127 | H.HB.14 |
Hydrophobic | TM6 | R | 274 | 6x28 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL3 | S | 268 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Polar | ICL3 | S | 264 | - | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | ICL3 | S | 264 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | C-term | I | 423 | - | H.HA | A | 102 | H.HA.25 |
Polar | H8 | S | 343 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | V | 136 | 3x54 | G.H5 | M | 375 | G.H5.24 |
Polar | TM6 | R | 278 | 6x32 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | R | 278 | 6x32 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM6 | T | 279 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Ionic | C-term | E | 420 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | E | 420 | - | H.HA | K | 105 | H.HA.28 |
Polar | C-term | T | 421 | - | H.HA | V | 98 | H.HA.21 |
Hydrophobic | C-term | T | 421 | - | H.HA | V | 98 | H.HA.21 |
Van-der-waals | C-term | T | 421 | - | H.HA | V | 98 | H.HA.21 |
Hydrophobic | ICL2 | P | 139 | 34x50 | G.H5 | L | 367 | G.H5.16 |
Polar | ICL3 | S | 264 | - | G.S6 | L | 342 | G.S6.01 |
Hydrophobic | ICL3 | S | 264 | - | G.S6 | L | 342 | G.S6.01 |
Van-der-waals | ICL3 | S | 264 | - | G.S6 | L | 342 | G.S6.01 |
Hydrophobic | ICL2 | L | 143 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | L | 143 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | C-term | I | 423 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | I | 423 | - | H.HA | K | 105 | H.HA.28 |
Polar | TM5 | N | 229 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Ionic | TM5 | K | 233 | 5x72 | G.H5 | D | 364 | G.H5.13 |
Polar | TM5 | K | 233 | 5x72 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM5 | K | 233 | 5x72 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | K | 233 | 5x72 | G.H5 | D | 364 | G.H5.13 |