Structure information

κ receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

4DJH

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE10939

PUBLICATION DATE

March 21, 2012

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
JDTic W124 23.50x50 ECL1 hydrophobic
JDTic V134 3.28x28 TM3 hydrophobic
JDTic L135 3.29x29 TM3 hydrophobic
JDTic D138 3.32x32 TM3 polar (charge-assisted hydrogen bond)
JDTic Y139 3.33x33 TM3 hydrophobic
JDTic Y139 3.33x33 TM3 Van der Waals
JDTic M142 3.36x36 TM3 hydrophobic
JDTic M142 3.36x36 TM3 Van der Waals
JDTic C210 45.50x50 ECL2 hydrophobic
JDTic C210 45.50x50 ECL2 Van der Waals
JDTic K227 5.39x40 TM5 Van der Waals
JDTic V230 5.42x43 TM5 Van der Waals
JDTic V230 5.42x43 TM5 hydrophobic
JDTic W287 6.48x48 TM6 hydrophobic
JDTic W287 6.48x48 TM6 Van der Waals
JDTic I290 6.51x51 TM6 hydrophobic
JDTic I290 6.51x51 TM6 Van der Waals
JDTic H291 6.52x52 TM6 Van der Waals
JDTic I294 6.55x55 TM6 Van der Waals
JDTic I294 6.55x55 TM6 hydrophobic
JDTic I316 7.39x38 TM7 Van der Waals
JDTic I316 7.39x38 TM7 hydrophobic
JDTic G319 7.42x41 TM7 Van der Waals
JDTic Y320 7.43x42 TM7 Van der Waals
JDTic Y320 7.43x42 TM7 hydrophobic

Ligands

JDTic

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Residue Diagrams

S N G V L G V V F V V S Y V A T I I V P 1 F N L A L A D A L V T T T M P F Q S T V 2 M T L T F I S T F M N Y Y D I S I V I K 3 A K I I N I C I W L L S S S V G I S A I 4 Y C V I I I L V P I V F A F I F V C I K M 5 L V V V A V F V V C W T P I H I F I L V 6 I P N L S S N T Y G L A I C F Y Y S S 7
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ICL1 T K M K ICL1ECL1 S W P F ECL1ICL2 P V K A L D F R ICL2ECL2 G T K V R E D V D V I E C S L Q F P D D ECL2ICL3 R L L S G ICL3ECL3 S T S H ECL3N-term M D S P I Q I F R G E P G P T C A P S A C L P P N S S A W F P G W A E P D S N G S A G S E D A Q L E P A H I S P N-termC-term P L K M R M E R Q S T S R V R N T V Q D P A Y L R D I D G M N K P V C-term A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P L K A K I I N I C I W L L S S S V G I S A I V L G D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F R D F K R C F C F
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Residue Table


GPCRdb(A)
GPCRdb(A)
κ receptor
ECL1
23x50 23.50x50 W124
TM3
3x28 3.28x28 V134
3x29 3.29x29 I135
3x32 3.32x32 D138
3x33 3.33x33 Y139
3x36 3.36x36 M142
ECL2
45x50 45.50x50 C210
TM5
5x40 5.39x40 K227
5x43 5.42x43 V230
TM6
6x48 6.48x48 W287
6x51 6.51x51 I290
6x52 6.52x52 H291
6x55 6.55x55 I294
TM7
7x38 7.39x38 I316
7x41 7.42x41 G319
7x42 7.43x42 Y320