Structure information

κ receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8DZS

SPECIES

Homo sapiens

RESOLUTION

2.650

PREFERRED CHAIN

A

REFERENCE

10.1038/S41586-023-06030-7

PUBLICATION DATE

May 3, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL277863 F114 2.59x59 TM2 hydrophobic
CHEMBL277863 Q115 2.60x60 TM2 polar (hydrogen bond)
CHEMBL277863 Q115 2.60x60 TM2 Van der Waals
CHEMBL277863 V134 3.28x28 TM3 hydrophobic
CHEMBL277863 V134 3.28x28 TM3 Van der Waals
CHEMBL277863 D138 3.32x32 TM3 polar (charge-assisted hydrogen bond)
CHEMBL277863 Y139 3.33x33 TM3 hydrophobic
CHEMBL277863 Y139 3.33x33 TM3 Van der Waals
CHEMBL277863 M142 3.36x36 TM3 hydrophobic
CHEMBL277863 M142 3.36x36 TM3 Van der Waals
CHEMBL277863 V230 5.42x43 TM5 Van der Waals
CHEMBL277863 W287 6.48x48 TM6 Van der Waals
CHEMBL277863 W287 6.48x48 TM6 hydrophobic
CHEMBL277863 I290 6.51x51 TM6 Van der Waals
CHEMBL277863 H291 6.52x52 TM6 Van der Waals
CHEMBL277863 I294 6.55x55 TM6 Van der Waals
CHEMBL277863 Y312 7.35x34 TM7 Van der Waals
CHEMBL277863 Y320 7.43x42 TM7 Van der Waals
CHEMBL277863 Y320 7.43x42 TM7 hydrophobic

Ligands

CHEMBL277863

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Residue Diagrams

S N G V L G V V F V V S Y V A T I I V P 1 F N L A L A D A L V T T T M P F Q S T V 2 M T L T F I S T F M N Y Y D I S I V I K 3 A K I I N I C I W L L S S S V G I S A I 4 Y C V I I I L V P I V F A F I F V C I K M 5 L V V V A V F V V C W T P I H I F I L V 6 I P N L S S N T Y G L A I C F Y Y S S 7
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ICL1 T K M K ICL1ECL1 S W P F ECL1ICL2 P V K A L D F R ICL2ECL2 G T K V R E D V D V I E C S L Q F P D D ECL2ICL3 R L L S G ICL3ECL3 S T S H ECL3N-term M D S P I Q I F R G E P G P T C A P S A C L P P N S S A W F P G W A E P D S N G S A G S E D A Q L E P A H I S P N-termC-term P L K M R M E R Q S T S R V R N T V Q D P A Y L R D I D G M N K P V C-term A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M N G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P L K A K I I N I C I W L L S S S V G I S A I V L G D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F R D F K R C F C F
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Residue Table


GPCRdb(A)
GPCRdb(A)
κ receptor
TM2
2x59 2.59x59 F114
2x60 2.60x60 Q115
TM3
3x28 3.28x28 V134
3x32 3.32x32 D138
3x33 3.33x33 Y139
3x36 3.36x36 M142
TM5
5x43 5.42x43 V230
TM6
6x48 6.48x48 W287
6x51 6.51x51 I290
6x52 6.52x52 H291
6x55 6.55x55 I294
TM7
7x34 7.35x34 Y312
7x42 7.43x42 Y320