P2RY10 (p2y10_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans P2RY10
GENE
P2RY10
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Putative P2Y purinoceptor 10, P2Y10, P2Y-like receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
N
|
L
|
D
|
K
|
Y
|
T
|
E
|
T
|
10 |
F
|
K
|
M
|
G
|
S
|
N
|
S
|
T
|
S
|
T
|
20 |
A
|
E
|
I
|
Y
|
C
|
N
|
V
|
T
|
N
|
V
|
30 |
TM1 | |||||||||
K
|
F
|
Q
|
Y
|
S
|
L
|
Y
|
A
|
T
|
T
|
40 |
Y
|
I
|
L
|
I
|
F
|
I
|
P
|
G
|
L
|
L
|
50 |
A
|
N
|
S
|
A
|
A
|
L
|
W
|
V
|
L
|
C
|
60 |
ICL1 | TM2 | ||||||||
R
|
F
|
I
|
S
|
K
|
K
|
N
|
K
|
A
|
I
|
70 |
I
|
F
|
M
|
I
|
N
|
L
|
S
|
V
|
A
|
D
|
80 |
L
|
A
|
H
|
V
|
L
|
S
|
L
|
P
|
L
|
R
|
90 |
I
|
Y
|
Y
|
Y
|
I
|
S
|
H
|
H
|
W
|
P
|
100 |
ECL1 | TM3 | ||||||||
F
|
Q
|
R
|
A
|
L
|
C
|
L
|
L
|
C
|
F
|
110 |
Y
|
L
|
K
|
Y
|
L
|
N
|
M
|
Y
|
A
|
S
|
120 |
I
|
C
|
F
|
L
|
T
|
C
|
I
|
S
|
L
|
Q
|
130 |
R
|
C
|
F
|
F
|
L
|
L
|
K
|
P
|
F
|
R
|
140 |
ICL2 | TM4 | ||||||||
A
|
R
|
D
|
W
|
K
|
R
|
R
|
Y
|
D
|
V
|
150 |
G
|
I
|
S
|
A
|
A
|
I
|
W
|
I
|
V
|
V
|
160 |
G
|
T
|
A
|
C
|
L
|
P
|
F
|
P
|
I
|
L
|
170 |
ECL2 | |||||||||
R
|
S
|
T
|
D
|
L
|
N
|
N
|
N
|
K
|
S
|
180 |
C
|
F
|
A
|
D
|
L
|
G
|
Y
|
K
|
Q
|
M
|
190 |
TM5 | |||||||||
N
|
A
|
V
|
A
|
L
|
V
|
G
|
M
|
I
|
T
|
200 |
V
|
A
|
E
|
L
|
A
|
G
|
F
|
V
|
I
|
P
|
210 |
V
|
I
|
I
|
I
|
A
|
W
|
C
|
T
|
W
|
K
|
220 |
T
|
T
|
I
|
S
|
L
|
R
|
Q
|
P
|
P
|
M
|
230 |
ICL3 | TM6 | ||||||||
A
|
F
|
Q
|
G
|
I
|
S
|
E
|
R
|
Q
|
K
|
240 |
A
|
L
|
R
|
M
|
V
|
F
|
M
|
C
|
A
|
A
|
250 |
V
|
F
|
F
|
I
|
C
|
F
|
T
|
P
|
Y
|
H
|
260 |
I
|
N
|
F
|
I
|
F
|
Y
|
T
|
M
|
V
|
K
|
270 |
ECL3 | TM7 | ||||||||
E
|
T
|
I
|
I
|
S
|
S
|
C
|
P
|
V
|
V
|
280 |
R
|
I
|
A
|
L
|
Y
|
F
|
H
|
P
|
F
|
C
|
290 |
L
|
C
|
L
|
A
|
S
|
L
|
C
|
C
|
L
|
L
|
300 |
D
|
P
|
I
|
L
|
Y
|
Y
|
F
|
M
|
A
|
S
|
310 |
H8 | |||||||||
E
|
F
|
R
|
D
|
Q
|
L
|
S
|
R
|
H
|
G
|
320 |
S
|
S
|
V
|
T
|
R
|
S
|
R
|
L
|
M
|
S
|
330 |
C-term | ||||||||
K
|
E
|
S
|
G
|
S
|
S
|
M
|
I
|
G
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
sphingosine 1-phosphate, LPA, 1-O-Oleoyl-D-glycerol 3-phosphoric acid, LYSOPHOSPHATIDIC ACID
STRUCTURE MODELS
STRUCTURES
Found 1 structure(s) - view all details on the Structures page
PDBs: 8KGG