NTS1 receptor (ntr1_rat)
FAMILY
Class A (Rhodopsin) Peptide receptors Neurotensin receptors NTS1 receptor
GENE
Ntsr1 (Ntsr)
ORGANISM
Rat (Rattus norvegicus)
ALT. NAMES
Neurotensin receptor type 1, NT-R-1, NTR1, High-affinity levocabastine-insensitive neurotensin receptor, NTRH
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
H
|
L
|
N
|
S
|
S
|
V
|
P
|
Q
|
G
|
10 |
T
|
P
|
G
|
E
|
P
|
D
|
A
|
Q
|
P
|
F
|
20 |
S
|
G
|
P
|
Q
|
S
|
E
|
M
|
E
|
A
|
T
|
30 |
F
|
L
|
A
|
L
|
S
|
L
|
S
|
N
|
G
|
S
|
40 |
G
|
N
|
T
|
S
|
E
|
S
|
D
|
T
|
A
|
G
|
50 |
P
|
N
|
S
|
D
|
L
|
D
|
V
|
N
|
T
|
D
|
60 |
TM1 | |||||||||
I
|
Y
|
S
|
K
|
V
|
L
|
V
|
T
|
A
|
I
|
70 |
Y
|
L
|
A
|
L
|
F
|
V
|
V
|
G
|
T
|
V
|
80 |
G
|
N
|
S
|
V
|
T
|
A
|
F
|
T
|
L
|
A
|
90 |
ICL1 | TM2 | ||||||||
R
|
K
|
K
|
S
|
L
|
Q
|
S
|
L
|
Q
|
S
|
100 |
T
|
V
|
H
|
Y
|
H
|
L
|
G
|
S
|
L
|
A
|
110 |
L
|
S
|
D
|
L
|
L
|
I
|
L
|
L
|
L
|
A
|
120 |
M
|
P
|
V
|
E
|
L
|
Y
|
N
|
F
|
I
|
W
|
130 |
ECL1 | TM3 | ||||||||
V
|
H
|
H
|
P
|
W
|
A
|
F
|
G
|
D
|
A
|
140 |
G
|
C
|
R
|
G
|
Y
|
Y
|
F
|
L
|
R
|
D
|
150 |
A
|
C
|
T
|
Y
|
A
|
T
|
A
|
L
|
N
|
V
|
160 |
A
|
S
|
L
|
S
|
V
|
E
|
R
|
Y
|
L
|
A
|
170 |
ICL2 | |||||||||
I
|
C
|
H
|
P
|
F
|
K
|
A
|
K
|
T
|
L
|
180 |
TM4 | |||||||||
M
|
S
|
R
|
S
|
R
|
T
|
K
|
K
|
F
|
I
|
190 |
S
|
A
|
I
|
W
|
L
|
A
|
S
|
A
|
L
|
L
|
200 |
A
|
I
|
P
|
M
|
L
|
F
|
T
|
M
|
G
|
L
|
210 |
ECL2 | |||||||||
Q
|
N
|
R
|
S
|
G
|
D
|
G
|
T
|
H
|
P
|
220 |
G
|
G
|
L
|
V
|
C
|
T
|
P
|
I
|
V
|
D
|
230 |
TM5 | |||||||||
T
|
A
|
T
|
V
|
K
|
V
|
V
|
I
|
Q
|
V
|
240 |
N
|
T
|
F
|
M
|
S
|
F
|
L
|
F
|
P
|
M
|
250 |
L
|
V
|
I
|
S
|
I
|
L
|
N
|
T
|
V
|
I
|
260 |
A
|
N
|
K
|
L
|
T
|
V
|
M
|
V
|
H
|
Q
|
270 |
ICL3 | |||||||||
A
|
A
|
E
|
Q
|
G
|
R
|
V
|
C
|
T
|
V
|
280 |
G
|
T
|
H
|
N
|
G
|
L
|
E
|
H
|
S
|
T
|
290 |
TM6 | |||||||||
F
|
N
|
M
|
T
|
I
|
E
|
P
|
G
|
R
|
V
|
300 |
Q
|
A
|
L
|
R
|
H
|
G
|
V
|
L
|
V
|
L
|
310 |
R
|
A
|
V
|
V
|
I
|
A
|
F
|
V
|
V
|
C
|
320 |
W
|
L
|
P
|
Y
|
H
|
V
|
R
|
R
|
L
|
M
|
330 |
ECL3 | |||||||||
F
|
C
|
Y
|
I
|
S
|
D
|
E
|
Q
|
W
|
T
|
340 |
TM7 | |||||||||
T
|
F
|
L
|
F
|
D
|
F
|
Y
|
H
|
Y
|
F
|
350 |
Y
|
M
|
L
|
T
|
N
|
A
|
L
|
F
|
Y
|
V
|
360 |
S
|
S
|
A
|
I
|
N
|
P
|
I
|
L
|
Y
|
N
|
370 |
H8 | |||||||||
L
|
V
|
S
|
A
|
N
|
F
|
R
|
Q
|
V
|
F
|
380 |
L
|
S
|
T
|
L
|
A
|
C
|
L
|
C
|
P
|
G
|
390 |
C-term | |||||||||
W
|
R
|
H
|
R
|
R
|
K
|
K
|
R
|
P
|
T
|
400 |
F
|
S
|
R
|
K
|
P
|
N
|
S
|
M
|
S
|
S
|
410 |
N
|
H
|
A
|
F
|
S
|
T
|
S
|
A
|
T
|
R
|
420 |
E
|
T
|
L
|
Y
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
neurotensin, neuromedin N
STRUCTURE MODELS
No structure models have been generated as experimental structures are available (see below).