NK2 receptor (nk2r_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Tachykinin receptors NK2 receptor
GENE
TACR2 (NK2R, NKNAR, TAC2R)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Substance-K receptor, SKR, NK-2 receptor, NK-2R, Neurokinin A receptor, Tachykinin receptor 2
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
G
|
T
|
C
|
D
|
I
|
V
|
T
|
E
|
A
|
10 |
N
|
I
|
S
|
S
|
G
|
P
|
E
|
S
|
N
|
T
|
20 |
T
|
G
|
I
|
T
|
A
|
F
|
S
|
M
|
P
|
S
|
30 |
TM1 | |||||||||
W
|
Q
|
L
|
A
|
L
|
W
|
A
|
T
|
A
|
Y
|
40 |
L
|
A
|
L
|
V
|
L
|
V
|
A
|
V
|
T
|
G
|
50 |
N
|
A
|
I
|
V
|
I
|
W
|
I
|
I
|
L
|
A
|
60 |
ICL1 | TM2 | ||||||||
H
|
R
|
R
|
M
|
R
|
T
|
V
|
T
|
N
|
Y
|
70 |
F
|
I
|
V
|
N
|
L
|
A
|
L
|
A
|
D
|
L
|
80 |
C
|
M
|
A
|
A
|
F
|
N
|
A
|
A
|
F
|
N
|
90 |
F
|
V
|
Y
|
A
|
S
|
H
|
N
|
I
|
W
|
Y
|
100 |
ECL1 | TM3 | ||||||||
F
|
G
|
R
|
A
|
F
|
C
|
Y
|
F
|
Q
|
N
|
110 |
L
|
F
|
P
|
I
|
T
|
A
|
M
|
F
|
V
|
S
|
120 |
I
|
Y
|
S
|
M
|
T
|
A
|
I
|
A
|
A
|
D
|
130 |
R
|
Y
|
M
|
A
|
I
|
V
|
H
|
P
|
F
|
Q
|
140 |
ICL2 | TM4 | ||||||||
P
|
R
|
L
|
S
|
A
|
P
|
S
|
T
|
K
|
A
|
150 |
V
|
I
|
A
|
G
|
I
|
W
|
L
|
V
|
A
|
L
|
160 |
A
|
L
|
A
|
S
|
P
|
Q
|
C
|
F
|
Y
|
S
|
170 |
ECL2 | |||||||||
T
|
V
|
T
|
M
|
D
|
Q
|
G
|
A
|
T
|
K
|
180 |
C
|
V
|
V
|
A
|
W
|
P
|
E
|
D
|
S
|
G
|
190 |
TM5 | |||||||||
G
|
K
|
T
|
L
|
L
|
L
|
Y
|
H
|
L
|
V
|
200 |
V
|
I
|
A
|
L
|
I
|
Y
|
F
|
L
|
P
|
L
|
210 |
A
|
V
|
M
|
F
|
V
|
A
|
Y
|
S
|
V
|
I
|
220 |
G
|
L
|
T
|
L
|
W
|
R
|
R
|
A
|
V
|
P
|
230 |
ICL3 | TM6 | ||||||||
G
|
H
|
Q
|
A
|
H
|
G
|
A
|
N
|
L
|
R
|
240 |
H
|
L
|
Q
|
A
|
M
|
K
|
K
|
F
|
V
|
K
|
250 |
T
|
M
|
V
|
L
|
V
|
V
|
L
|
T
|
F
|
A
|
260 |
I
|
C
|
W
|
L
|
P
|
Y
|
H
|
L
|
Y
|
F
|
270 |
ECL3 | |||||||||
I
|
L
|
G
|
S
|
F
|
Q
|
E
|
D
|
I
|
Y
|
280 |
TM7 | |||||||||
C
|
H
|
K
|
F
|
I
|
Q
|
Q
|
V
|
Y
|
L
|
290 |
A
|
L
|
F
|
W
|
L
|
A
|
M
|
S
|
S
|
T
|
300 |
M
|
Y
|
N
|
P
|
I
|
I
|
Y
|
C
|
C
|
L
|
310 |
H8 | |||||||||
N
|
H
|
R
|
F
|
R
|
S
|
G
|
F
|
R
|
L
|
320 |
C-term | |||||||||
A
|
F
|
R
|
C
|
C
|
P
|
W
|
V
|
T
|
P
|
330 |
T
|
K
|
E
|
D
|
K
|
L
|
E
|
L
|
T
|
P
|
340 |
T
|
T
|
S
|
L
|
S
|
T
|
R
|
V
|
N
|
R
|
350 |
C
|
H
|
T
|
K
|
E
|
T
|
L
|
F
|
M
|
A
|
360 |
G
|
D
|
T
|
A
|
P
|
S
|
E
|
A
|
T
|
S
|
370 |
G
|
E
|
A
|
G
|
R
|
P
|
Q
|
D
|
G
|
S
|
380 |
G
|
L
|
W
|
F
|
G
|
Y
|
G
|
L
|
L
|
A
|
390 |
P
|
T
|
K
|
T
|
H
|
V
|
E
|
I
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
neurokinin A, substance P, hemokinin 1, neuropeptide K, neuropeptide γ, neurokinin B
STRUCTURE MODELS
STRUCTURES
Found 1 structure(s) - view all details on the Structures page
PDBs: 7XWO