NK3 receptor (nk3r_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Tachykinin receptors NK3 receptor
GENE
TACR3 (NK3R, TAC3R)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Neuromedin-K receptor, NKR, NK-3 receptor, NK-3R, Neurokinin B receptor, Tachykinin receptor 3
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
T
|
L
|
P
|
A
|
A
|
E
|
T
|
W
|
10 |
I
|
D
|
G
|
G
|
G
|
G
|
V
|
G
|
A
|
D
|
20 |
A
|
V
|
N
|
L
|
T
|
A
|
S
|
L
|
A
|
A
|
30 |
G
|
A
|
A
|
T
|
G
|
A
|
V
|
E
|
T
|
G
|
40 |
W
|
L
|
Q
|
L
|
L
|
D
|
Q
|
A
|
G
|
N
|
50 |
L
|
S
|
S
|
S
|
P
|
S
|
A
|
L
|
G
|
L
|
60 |
P
|
V
|
A
|
S
|
P
|
A
|
P
|
S
|
Q
|
P
|
70 |
W
|
A
|
N
|
L
|
T
|
N
|
Q
|
F
|
V
|
Q
|
80 |
TM1 | |||||||||
P
|
S
|
W
|
R
|
I
|
A
|
L
|
W
|
S
|
L
|
90 |
A
|
Y
|
G
|
V
|
V
|
V
|
A
|
V
|
A
|
V
|
100 |
L
|
G
|
N
|
L
|
I
|
V
|
I
|
W
|
I
|
I
|
110 |
ICL1 | TM2 | ||||||||
L
|
A
|
H
|
K
|
R
|
M
|
R
|
T
|
V
|
T
|
120 |
N
|
Y
|
F
|
L
|
V
|
N
|
L
|
A
|
F
|
S
|
130 |
D
|
A
|
S
|
M
|
A
|
A
|
F
|
N
|
T
|
L
|
140 |
V
|
N
|
F
|
I
|
Y
|
A
|
L
|
H
|
S
|
E
|
150 |
ECL1 | TM3 | ||||||||
W
|
Y
|
F
|
G
|
A
|
N
|
Y
|
C
|
R
|
F
|
160 |
Q
|
N
|
F
|
F
|
P
|
I
|
T
|
A
|
V
|
F
|
170 |
A
|
S
|
I
|
Y
|
S
|
M
|
T
|
A
|
I
|
A
|
180 |
V
|
D
|
R
|
Y
|
M
|
A
|
I
|
I
|
D
|
P
|
190 |
ICL2 | TM4 | ||||||||
L
|
K
|
P
|
R
|
L
|
S
|
A
|
T
|
A
|
T
|
200 |
K
|
I
|
V
|
I
|
G
|
S
|
I
|
W
|
I
|
L
|
210 |
A
|
F
|
L
|
L
|
A
|
F
|
P
|
Q
|
C
|
L
|
220 |
ECL2 | |||||||||
Y
|
S
|
K
|
T
|
K
|
V
|
M
|
P
|
G
|
R
|
230 |
T
|
L
|
C
|
F
|
V
|
Q
|
W
|
P
|
E
|
G
|
240 |
TM5 | |||||||||
P
|
K
|
Q
|
H
|
F
|
T
|
Y
|
H
|
I
|
I
|
250 |
V
|
I
|
I
|
L
|
V
|
Y
|
C
|
F
|
P
|
L
|
260 |
L
|
I
|
M
|
G
|
I
|
T
|
Y
|
T
|
I
|
V
|
270 |
G
|
I
|
T
|
L
|
W
|
G
|
G
|
E
|
I
|
P
|
280 |
ICL3 | TM6 | ||||||||
G
|
D
|
T
|
C
|
D
|
K
|
Y
|
H
|
E
|
Q
|
290 |
L
|
K
|
A
|
K
|
R
|
K
|
V
|
V
|
K
|
M
|
300 |
M
|
I
|
I
|
V
|
V
|
M
|
T
|
F
|
A
|
I
|
310 |
C
|
W
|
L
|
P
|
Y
|
H
|
I
|
Y
|
F
|
I
|
320 |
ECL3 | |||||||||
L
|
T
|
A
|
I
|
Y
|
Q
|
Q
|
L
|
N
|
R
|
330 |
TM7 | |||||||||
W
|
K
|
Y
|
I
|
Q
|
Q
|
V
|
Y
|
L
|
A
|
340 |
S
|
F
|
W
|
L
|
A
|
M
|
S
|
S
|
T
|
M
|
350 |
Y
|
N
|
P
|
I
|
I
|
Y
|
C
|
C
|
L
|
N
|
360 |
H8 | |||||||||
K
|
R
|
F
|
R
|
A
|
G
|
F
|
K
|
R
|
A
|
370 |
C-term | |||||||||
F
|
R
|
W
|
C
|
P
|
F
|
I
|
K
|
V
|
S
|
380 |
S
|
Y
|
D
|
E
|
L
|
E
|
L
|
K
|
T
|
T
|
390 |
R
|
F
|
H
|
P
|
N
|
R
|
Q
|
S
|
S
|
M
|
400 |
Y
|
T
|
V
|
T
|
R
|
M
|
E
|
S
|
M
|
T
|
410 |
V
|
V
|
F
|
D
|
P
|
N
|
D
|
A
|
D
|
T
|
420 |
T
|
R
|
S
|
S
|
R
|
K
|
K
|
R
|
A
|
T
|
430 |
P
|
R
|
D
|
P
|
S
|
F
|
N
|
G
|
C
|
S
|
440 |
R
|
R
|
N
|
S
|
K
|
S
|
A
|
S
|
A
|
T
|
450 |
S
|
S
|
F
|
I
|
S
|
S
|
P
|
Y
|
T
|
S
|
460 |
V
|
D
|
E
|
Y
|
S
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
substance P, neurokinin A, neurokinin B
STRUCTURE MODELS
STRUCTURES
Found 3 structure(s) - view all details on the Structures page