Gs - BLT2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 V 123 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 123 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 123 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM5 Y 201 5x58 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 127 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 127 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM5 L 208 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 208 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM6 H 218 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 H 218 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM6 V 226 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 226 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 F 127 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 127 34x51 G.H5 I 383 G.H5.15
Hydrophobic ICL2 F 127 34x51 G.S3 F 219 G.S3.03
Hydrophobic C-term L 327 - G.H3 S 275 G.H3.11
Van-der-waals C-term L 327 - G.H3 S 275 G.H3.11
Ionic C-term E 313 - G.h3s5 R 283 G.h3s5.01
Hydrophobic C-term M 325 - G.H3 R 280 G.H3.16
Van-der-waals C-term M 325 - G.H3 R 280 G.H3.16
Hydrophobic ICL1 R 52 12x51 G.HN K 34 G.HN.51
Polar ICL2 R 133 34x57 G.H5 Q 390 G.H5.22
Van-der-waals ICL2 R 133 34x57 G.H5 Q 390 G.H5.22
Polar ICL1 A 51 12x50 G.HN K 34 G.HN.51
Van-der-waals ICL1 A 51 12x50 G.HN K 34 G.HN.51
Polar ICL2 R 131 34x55 G.s2s3 K 216 G.s2s3.02
Polar C-term R 315 - G.H3 W 281 G.H3.17
Hydrophobic C-term R 315 - G.H3 W 281 G.H3.17
Van-der-waals C-term R 315 - G.H3 W 281 G.H3.17
Polar C-term G 323 - G.H3 R 280 G.H3.16
Van-der-waals C-term G 323 - G.H3 R 280 G.H3.16
Hydrophobic C-term M 325 - G.H3 N 279 G.H3.15
Van-der-waals C-term M 325 - G.H3 N 279 G.H3.15
Hydrophobic TM3 V 123 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 V 123 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 P 126 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 126 34x50 G.H5 R 380 G.H5.12
Polar TM3 Q 118 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 Q 118 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Q 118 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM6 V 222 6x33 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 127 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 127 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL2 A 129 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 A 129 34x53 G.H5 H 387 G.H5.19
Polar TM7 T 291 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM7 T 291 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 T 291 7x56 G.H5 E 392 G.H5.24
Hydrophobic C-term M 325 - G.H3 W 281 G.H3.17
Van-der-waals C-term M 325 - G.H3 W 281 G.H3.17
Hydrophobic ICL2 P 130 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic TM6 V 222 6x33 G.H5 L 394 G.H5.26
Van-der-waals TM6 V 222 6x33 G.H5 L 394 G.H5.26
Polar C-term F 308 - G.H5 Q 390 G.H5.22
Hydrophobic C-term F 308 - G.H5 Q 390 G.H5.22
Van-der-waals C-term F 308 - G.H5 Q 390 G.H5.22
Hydrophobic C-term L 333 - G.H3 Q 267 G.H3.03
Van-der-waals C-term L 333 - G.H3 Q 267 G.H3.03
Hydrophobic C-term L 307 - G.H5 E 392 G.H5.24
Van-der-waals C-term L 307 - G.H5 E 392 G.H5.24
Hydrophobic ICL3 W 213 - G.H5 L 388 G.H5.20
Van-der-waals ICL3 W 213 - G.H5 L 388 G.H5.20
Hydrophobic TM4 P 135 4x39 G.HN Q 31 G.HN.48
Van-der-waals TM4 P 135 4x39 G.HN Q 31 G.HN.48
Hydrophobic TM2 A 57 2x39 G.H5 Y 391 G.H5.23
Aromatic ICL2 F 127 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 127 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 127 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL3 W 213 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 W 213 - G.H5 R 385 G.H5.17
Polar TM4 S 134 4x38 G.HN Q 35 G.HN.52
Hydrophobic TM4 S 134 4x38 G.HN Q 35 G.HN.52
Polar ICL3 W 213 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 W 213 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 W 213 - G.H5 D 381 G.H5.13
Polar TM6 V 222 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 V 222 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 222 6x33 G.H5 L 393 G.H5.25
Polar C-term E 309 - G.H5 Q 390 G.H5.22
Hydrophobic C-term E 309 - G.H5 Q 390 G.H5.22
Hydrophobic ICL2 P 126 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 126 34x50 G.H5 I 383 G.H5.15
Hydrophobic ICL3 W 213 - G.H5 Q 384 G.H5.16
Van-der-waals ICL3 W 213 - G.H5 Q 384 G.H5.16
Polar C-term R 315 - G.H3 R 280 G.H3.16
Van-der-waals C-term R 315 - G.H3 R 280 G.H3.16
Hydrophobic ICL2 P 130 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 P 130 34x54 G.hns1 R 38 G.hns1.02
Polar TM3 A 122 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 122 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 122 3x53 G.H5 H 387 G.H5.19
Aromatic ICL2 F 127 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 127 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 127 34x51 G.S1 H 41 G.S1.02
Hydrophobic C-term L 327 - G.H2 W 234 G.H2.07
Hydrophobic ICL2 P 126 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 126 34x50 G.H5 Q 384 G.H5.16
Polar ICL1 R 52 12x51 G.hns1 R 38 G.hns1.02
Hydrophobic ICL1 R 52 12x51 G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 R 52 12x51 G.hns1 R 38 G.hns1.02
Ionic ICL1 R 52 12x51 G.h2s4 D 240 G.h2s4.03
Polar ICL1 R 52 12x51 G.h2s4 D 240 G.h2s4.03
Hydrophobic ICL1 R 52 12x51 G.h2s4 D 240 G.h2s4.03
Van-der-waals ICL1 R 52 12x51 G.h2s4 D 240 G.h2s4.03
Ionic C-term E 313 - G.h4s6 R 356 G.h4s6.12
Polar C-term E 313 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term E 313 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term E 313 - G.h4s6 R 356 G.h4s6.12
Hydrophobic TM6 L 225 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 L 225 6x36 G.H5 E 392 G.H5.24
Polar TM7 A 292 7x57 G.H5 E 392 G.H5.24
Hydrophobic TM7 A 292 7x57 G.H5 E 392 G.H5.24
Van-der-waals TM7 A 292 7x57 G.H5 E 392 G.H5.24
Hydrophobic C-term G 310 - G.H5 Q 390 G.H5.22
Hydrophobic ICL2 F 127 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM3 A 122 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 A 122 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 V 123 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 126 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 126 34x50 G.H5 H 387 G.H5.19
Polar TM3 R 119 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 119 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 119 3x50 G.H5 L 393 G.H5.25
Van-der-waals C-term L 307 - G.H5 Q 390 G.H5.22