Gs - MRGPRX4 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ECL3 L 246 - G.h3s5 T 284 G.h3s5.02
Van-der-waals ECL3 L 246 - G.h3s5 T 284 G.h3s5.02
Polar ECL3 E 247 - G.H5 L 394 G.H5.26
Hydrophobic ECL3 E 247 - G.H5 L 394 G.H5.26
Van-der-waals ECL3 E 247 - G.H5 L 394 G.H5.26
Polar ECL1 I 90 - G.h2s4 N 239 G.h2s4.02
Ionic TM5 D 169 5x32 G.H3 K 274 G.H3.10
Polar TM5 D 169 5x32 G.H3 K 274 G.H3.10
Hydrophobic TM5 D 169 5x32 G.H3 K 274 G.H3.10
Van-der-waals TM5 D 169 5x32 G.H3 K 274 G.H3.10
Ionic TM5 D 177 5x40 G.H3 R 280 G.H3.16
Polar TM5 D 177 5x40 G.H3 R 280 G.H3.16
Van-der-waals TM5 D 177 5x40 G.H3 R 280 G.H3.16
Polar ECL3 R 241 - G.h4s6 R 356 G.h4s6.12
Hydrophobic ECL3 R 241 - G.h4s6 R 356 G.h4s6.12
Van-der-waals ECL3 R 241 - G.h4s6 R 356 G.h4s6.12
Polar N-term E 20 - G.HN Q 31 G.HN.48
Hydrophobic TM3 L 93 3x23 G.H2 Q 236 G.H2.09
Hydrophobic N-term L 12 - G.s2s3 K 216 G.s2s3.02
Polar ECL2 D 162 - G.H3 W 281 G.H3.17
Hydrophobic ECL2 D 162 - G.H3 W 281 G.H3.17
Van-der-waals ECL2 D 162 - G.H3 W 281 G.H3.17
Hydrophobic N-term I 15 - G.H5 L 388 G.H5.20
Polar TM3 K 96 3x26 G.H3 W 281 G.H3.17
Hydrophobic TM3 K 96 3x26 G.H3 W 281 G.H3.17
Van-der-waals TM3 K 96 3x26 G.H3 W 281 G.H3.17
Polar TM3 H 92 3x22 G.h2s4 F 238 G.h2s4.01
Hydrophobic N-term R 18 - G.HN Q 35 G.HN.52
Van-der-waals N-term R 18 - G.HN Q 35 G.HN.52
Ionic ECL3 H 243 - G.h4s6 D 354 G.h4s6.10
Polar ECL3 H 243 - G.h4s6 D 354 G.h4s6.10
Hydrophobic ECL3 H 243 - G.h4s6 D 354 G.h4s6.10
Van-der-waals ECL3 H 243 - G.h4s6 D 354 G.h4s6.10
Hydrophobic N-term L 12 - G.s2s3 D 215 G.s2s3.01
Van-der-waals N-term L 12 - G.s2s3 D 215 G.s2s3.01
Hydrophobic ECL3 L 246 - G.H5 L 393 G.H5.25
Van-der-waals ECL3 L 246 - G.H5 L 393 G.H5.25
Polar N-term T 21 - G.H5 L 394 G.H5.26
Hydrophobic N-term T 21 - G.H5 L 394 G.H5.26
Van-der-waals N-term T 21 - G.H5 L 394 G.H5.26
Ionic ECL2 D 162 - G.H3 R 280 G.H3.16
Polar ECL2 D 162 - G.H3 R 280 G.H3.16
Van-der-waals ECL2 D 162 - G.H3 R 280 G.H3.16
Hydrophobic ECL2 F 165 - G.H2 R 231 G.H2.04
Van-der-waals ECL2 F 165 - G.H2 R 231 G.H2.04
Polar ECL3 Y 240 - G.h3s5 R 283 G.h3s5.01
Van-der-waals ECL3 Y 240 - G.h3s5 R 283 G.h3s5.01
Hydrophobic ECL2 L 164 - G.h2s4 F 238 G.h2s4.01
Van-der-waals ECL2 L 164 - G.h2s4 F 238 G.h2s4.01
Polar TM3 H 92 3x22 G.h2s4 N 239 G.h2s4.02
Hydrophobic TM3 H 92 3x22 G.h2s4 N 239 G.h2s4.02
Van-der-waals TM3 H 92 3x22 G.h2s4 N 239 G.h2s4.02
Hydrophobic ECL2 F 165 - G.H2 W 234 G.H2.07
Polar N-term E 19 - G.hns1 R 38 G.hns1.02
Hydrophobic TM7 C 251 7x31 G.H5 L 394 G.H5.26
Van-der-waals TM7 C 251 7x31 G.H5 L 394 G.H5.26
Polar ECL3 Y 240 - G.H3 R 280 G.H3.16
Aromatic ECL3 Y 240 - G.H3 R 280 G.H3.16
Hydrophobic ECL3 Y 240 - G.H3 R 280 G.H3.16
Van-der-waals ECL3 Y 240 - G.H3 R 280 G.H3.16
Polar ECL3 M 242 - G.h4s6 R 356 G.h4s6.12
Hydrophobic ECL3 M 242 - G.h4s6 R 356 G.h4s6.12
Van-der-waals ECL3 M 242 - G.h4s6 R 356 G.h4s6.12
Polar ECL3 Y 240 - G.h4s6 R 356 G.h4s6.12
Hydrophobic ECL3 Y 240 - G.h4s6 R 356 G.h4s6.12
Van-der-waals ECL3 Y 240 - G.h4s6 R 356 G.h4s6.12
Hydrophobic N-term Y 24 - G.hns1 R 38 G.hns1.02
Van-der-waals N-term Y 24 - G.hns1 R 38 G.hns1.02
Polar N-term T 21 - G.hns1 R 38 G.hns1.02
Van-der-waals N-term T 21 - G.hns1 R 38 G.hns1.02
Hydrophobic ECL2 L 164 - G.H3 I 276 G.H3.12
Ionic TM3 R 95 3x25 G.h2s4 D 240 G.h2s4.03
Polar TM3 R 95 3x25 G.h2s4 D 240 G.h2s4.03
Hydrophobic ECL3 N 245 - G.H5 L 393 G.H5.25
Van-der-waals ECL3 N 245 - G.H5 L 393 G.H5.25
Hydrophobic TM3 S 91 3x21 G.h2s4 N 239 G.h2s4.02
Van-der-waals TM3 S 91 3x21 G.h2s4 N 239 G.h2s4.02
Polar ECL3 I 239 - G.h4s6 R 356 G.h4s6.12
Hydrophobic TM4 C 161 4x64 G.H3 R 280 G.H3.16
Van-der-waals TM4 C 161 4x64 G.H3 R 280 G.H3.16
Polar TM3 R 95 3x25 G.h2s4 N 239 G.h2s4.02
Van-der-waals TM3 R 95 3x25 G.h2s4 N 239 G.h2s4.02
Polar ECL3 E 247 - G.H5 E 392 G.H5.24
Hydrophobic ECL3 E 247 - G.H5 E 392 G.H5.24
Van-der-waals ECL3 E 247 - G.H5 E 392 G.H5.24
Polar N-term R 18 - G.HN Q 31 G.HN.48
Hydrophobic N-term C 23 - G.H5 L 394 G.H5.26
Van-der-waals N-term C 23 - G.H5 L 394 G.H5.26
Hydrophobic ECL2 F 165 - G.H2 R 232 G.H2.05
Van-der-waals ECL2 F 165 - G.H2 R 232 G.H2.05
Hydrophobic TM5 S 170 5x33 G.H3 N 278 G.H3.14
Van-der-waals TM5 S 170 5x33 G.H3 N 278 G.H3.14
Polar N-term Y 24 - G.HN K 34 G.HN.51
Aromatic N-term Y 24 - G.HN K 34 G.HN.51
Hydrophobic N-term Y 24 - G.HN K 34 G.HN.51
Van-der-waals N-term Y 24 - G.HN K 34 G.HN.51
Polar ECL3 H 243 - G.h4s6 R 356 G.h4s6.12
Aromatic ECL3 H 243 - G.h4s6 R 356 G.h4s6.12
Hydrophobic ECL3 H 243 - G.h4s6 R 356 G.h4s6.12
Van-der-waals ECL3 H 243 - G.h4s6 R 356 G.h4s6.12
Hydrophobic TM3 L 93 3x23 G.H2 I 235 G.H2.08
Van-der-waals TM3 L 93 3x23 G.H2 I 235 G.H2.08
Hydrophobic ECL2 L 164 - G.H2 I 235 G.H2.08
Van-der-waals ECL2 L 164 - G.H2 I 235 G.H2.08
Hydrophobic TM5 C 173 5x36 G.H3 R 280 G.H3.16
Polar ECL2 L 164 - G.H3 N 279 G.H3.15
Hydrophobic ECL2 L 164 - G.H3 N 279 G.H3.15
Van-der-waals ECL2 L 164 - G.H3 N 279 G.H3.15
Van-der-waals ECL3 E 247 - G.H5 Y 391 G.H5.23
Hydrophobic ECL2 L 164 - G.H3 W 281 G.H3.17
Polar ECL3 E 247 - G.H5 L 393 G.H5.25
Hydrophobic ECL3 E 247 - G.H5 L 393 G.H5.25
Van-der-waals ECL3 E 247 - G.H5 L 393 G.H5.25
Ionic TM4 E 157 4x60 G.H3 R 280 G.H3.16
Polar TM4 E 157 4x60 G.H3 R 280 G.H3.16
Hydrophobic TM4 E 157 4x60 G.H3 R 280 G.H3.16
Van-der-waals TM4 E 157 4x60 G.H3 R 280 G.H3.16