G12 - Y4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 16.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 142 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 142 3x53 G.H5 I 378 G.H5.23
Aromatic TM5 F 248 5x72 G.H5 H 364 G.H5.09
Hydrophobic TM5 F 248 5x72 G.H5 H 364 G.H5.09
Van-der-waals TM5 F 248 5x72 G.H5 H 364 G.H5.09
Hydrophobic TM5 F 248 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 F 248 5x72 G.H5 D 368 G.H5.13
Polar ICL3 Y 253 - G.S6 L 346 G.S6.01
Polar H8 T 327 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 T 327 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 T 327 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM6 M 260 6x30 G.H5 L 375 G.H5.20
Ionic ICL2 K 150 - G.H5 D 377 G.H5.22
Polar ICL2 K 150 - G.H5 D 377 G.H5.22
Hydrophobic TM3 I 143 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 143 3x54 G.H5 L 375 G.H5.20
Polar TM6 H 259 6x29 G.H5 Q 372 G.H5.17
Hydrophobic C-term L 352 - G.H3 K 284 G.H3.16
Hydrophobic TM6 V 263 6x33 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 146 - G.H5 L 371 G.H5.16
Hydrophobic TM5 V 247 5x71 G.H5 H 364 G.H5.09
Van-der-waals TM5 V 247 5x71 G.H5 H 364 G.H5.09
Hydrophobic TM5 L 241 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 241 5x65 G.H5 L 375 G.H5.20
Hydrophobic C-term L 354 - G.H3 N 283 G.H3.15
Van-der-waals C-term L 354 - G.H3 N 283 G.H3.15
Hydrophobic ICL2 P 146 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 146 - G.H5 K 367 G.H5.12
Polar TM5 Q 244 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 Q 244 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM6 Q 262 6x32 G.H5 M 379 G.H5.24
Polar H8 N 326 8x47 G.H5 I 378 G.H5.23
Polar H8 T 327 8x48 G.H5 M 379 G.H5.24
Polar ICL2 K 150 - G.H5 N 374 G.H5.19
Ionic TM6 R 256 6x26 G.H5 D 368 G.H5.13
Polar TM6 R 256 6x26 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 256 6x26 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 256 6x26 G.H5 D 368 G.H5.13
Polar H8 N 326 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 N 326 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 326 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM6 R 256 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 256 6x26 G.H5 Q 372 G.H5.17
Polar TM3 L 142 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 L 142 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 L 142 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 I 143 3x54 G.H5 I 378 G.H5.23
Polar H8 N 328 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 328 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 328 8x49 G.H5 Q 381 G.H5.26
Polar ICL3 Y 253 - G.h4s6 R 339 G.h4s6.08
Van-der-waals ICL3 Y 253 - G.h4s6 R 339 G.h4s6.08
Hydrophobic ICL2 P 146 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 146 - G.H5 I 370 G.H5.15
Hydrophobic TM5 L 241 5x65 G.H5 L 371 G.H5.16
Hydrophobic TM6 M 260 6x30 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 T 147 - G.H5 I 370 G.H5.15
Hydrophobic TM6 V 266 6x36 G.H5 M 379 G.H5.24
Polar TM6 H 259 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 H 259 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 H 259 6x29 G.H5 Q 381 G.H5.26
Polar ICL2 G 148 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 G 148 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 G 148 - G.hns1 R 56 G.hns1.03
Hydrophobic H8 F 329 8x50 G.H5 L 380 G.H5.25
Polar ICL3 Y 253 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 Y 253 - G.h4s6 R 342 G.h4s6.11
Van-der-waals H8 K 331 8x52 G.H5 Q 381 G.H5.26
Hydrophobic C-term L 354 - G.h2s4 F 242 G.h2s4.01
Polar TM3 R 139 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 T 147 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 T 147 - G.S3 I 221 G.S3.01
Hydrophobic TM5 F 248 5x72 G.S6 F 347 G.S6.02
Van-der-waals TM5 F 248 5x72 G.S6 F 347 G.S6.02
Polar H8 T 327 8x48 G.H5 L 380 G.H5.25
Hydrophobic H8 T 327 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 T 327 8x48 G.H5 L 380 G.H5.25
Polar H8 N 328 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 N 328 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 N 328 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM5 Q 244 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 Q 244 5x68 G.H5 L 371 G.H5.16
Polar ICL3 Y 253 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL3 Y 253 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 Y 253 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL3 Y 253 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 Y 253 - G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL2 T 147 - G.H5 K 367 G.H5.12
Hydrophobic TM6 V 263 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 263 6x33 G.H5 M 379 G.H5.24
Polar ICL1 A 73 12x51 G.hns1 R 55 G.hns1.02
Polar ICL2 P 146 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 146 - G.H5 N 374 G.H5.19
Polar ICL2 P 151 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 P 151 - G.hns1 R 55 G.hns1.02
Hydrophobic TM4 S 152 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 S 152 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 R 240 5x64 G.H5 K 367 G.H5.12
Van-der-waals TM5 R 240 5x64 G.H5 K 367 G.H5.12
Hydrophobic H8 N 326 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 N 326 8x47 G.H5 M 379 G.H5.24
Ionic C-term E 350 - G.H3 K 284 G.H3.16
Polar C-term E 350 - G.H3 K 284 G.H3.16
Van-der-waals C-term E 350 - G.H3 K 284 G.H3.16
Hydrophobic C-term L 354 - G.H3 T 279 G.H3.11
Van-der-waals C-term L 354 - G.H3 T 279 G.H3.11
Polar ICL3 Y 253 - G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL3 Y 253 - G.h4s6 K 344 G.h4s6.19
Van-der-waals ICL3 Y 253 - G.h4s6 K 344 G.h4s6.19
Hydrophobic TM3 I 143 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 143 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 W 149 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 W 149 - G.hns1 R 56 G.hns1.03