Gt1 -
Y4 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | C-term | L | 354 | - | G.H3 | S | 248 | G.H3.11 |
Van-der-waals | C-term | L | 354 | - | G.H3 | S | 248 | G.H3.11 |
Ionic | C-term | K | 363 | - | G.s4h3 | E | 235 | G.s4h3.13 |
Polar | C-term | K | 363 | - | G.s4h3 | E | 235 | G.s4h3.13 |
Van-der-waals | C-term | K | 363 | - | G.s4h3 | E | 235 | G.s4h3.13 |
Hydrophobic | TM6 | L | 267 | 6x37 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | ICL2 | T | 147 | - | G.S3 | L | 190 | G.S3.01 |
Van-der-waals | ICL2 | T | 147 | - | G.S3 | L | 190 | G.S3.01 |
Hydrophobic | C-term | L | 354 | - | G.H2 | W | 207 | G.H2.07 |
Polar | ICL2 | G | 148 | - | G.hns1 | R | 28 | G.hns1.03 |
Hydrophobic | ICL2 | G | 148 | - | G.hns1 | R | 28 | G.hns1.03 |
Hydrophobic | C-term | S | 362 | - | G.s4h3 | V | 236 | G.s4h3.14 |
Polar | C-term | S | 355 | - | G.H2 | R | 204 | G.H2.04 |
Van-der-waals | C-term | S | 355 | - | G.H2 | R | 204 | G.H2.04 |
Hydrophobic | ICL2 | P | 146 | - | G.H5 | I | 339 | G.H5.15 |
Van-der-waals | ICL2 | P | 146 | - | G.H5 | I | 339 | G.H5.15 |
Polar | C-term | S | 362 | - | G.H3 | H | 244 | G.H3.07 |
Hydrophobic | C-term | S | 362 | - | G.H3 | H | 244 | G.H3.07 |
Hydrophobic | TM6 | M | 260 | 6x30 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | M | 260 | 6x30 | G.H5 | F | 350 | G.H5.26 |
Aromatic | TM5 | F | 248 | 5x72 | G.S6 | Y | 316 | G.S6.02 |
Hydrophobic | TM5 | F | 248 | 5x72 | G.S6 | Y | 316 | G.S6.02 |
Van-der-waals | TM5 | F | 248 | 5x72 | G.S6 | Y | 316 | G.S6.02 |
Polar | C-term | S | 355 | - | G.H3 | S | 248 | G.H3.11 |
Hydrophobic | C-term | S | 355 | - | G.H3 | S | 248 | G.H3.11 |
Van-der-waals | C-term | S | 355 | - | G.H3 | S | 248 | G.H3.11 |
Hydrophobic | C-term | T | 356 | - | G.H2 | R | 204 | G.H2.04 |
Hydrophobic | TM6 | V | 266 | 6x36 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | C-term | L | 354 | - | G.H3 | I | 249 | G.H3.12 |
Van-der-waals | C-term | L | 354 | - | G.H3 | I | 249 | G.H3.12 |
Hydrophobic | TM6 | V | 263 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM6 | V | 263 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Polar | H8 | T | 327 | 8x48 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | H8 | T | 327 | 8x48 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | H8 | T | 327 | 8x48 | G.H5 | F | 350 | G.H5.26 |
Polar | ICL3 | Y | 253 | - | G.h4s6 | N | 307 | G.h4s6.02 |
Hydrophobic | TM2 | T | 76 | 2x39 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM6 | M | 270 | 6x40 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | H8 | N | 328 | 8x49 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | H8 | N | 326 | 8x47 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | H8 | N | 326 | 8x47 | G.H5 | G | 348 | G.H5.24 |
Polar | TM3 | L | 142 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM3 | L | 142 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | TM3 | L | 142 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM3 | R | 139 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM5 | F | 248 | 5x72 | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | TM5 | F | 248 | 5x72 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | TM6 | V | 263 | 6x33 | G.H5 | L | 344 | G.H5.20 |
Polar | ICL3 | Y | 253 | - | G.H4 | L | 304 | G.H4.16 |
Hydrophobic | ICL3 | Y | 253 | - | G.H4 | L | 304 | G.H4.16 |
Van-der-waals | ICL3 | Y | 253 | - | G.H4 | L | 304 | G.H4.16 |
Hydrophobic | C-term | L | 366 | - | G.s4h3 | E | 235 | G.s4h3.13 |
Van-der-waals | C-term | L | 366 | - | G.s4h3 | E | 235 | G.s4h3.13 |
Hydrophobic | TM5 | F | 248 | 5x72 | G.H5 | A | 334 | G.H5.10 |
Van-der-waals | TM5 | F | 248 | 5x72 | G.H5 | A | 334 | G.H5.10 |
Polar | C-term | H | 351 | - | G.H3 | R | 253 | G.H3.16 |
Aromatic | C-term | H | 351 | - | G.H3 | R | 253 | G.H3.16 |
Hydrophobic | C-term | H | 351 | - | G.H3 | R | 253 | G.H3.16 |
Van-der-waals | C-term | H | 351 | - | G.H3 | R | 253 | G.H3.16 |
Aromatic | TM6 | H | 259 | 6x29 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM6 | H | 259 | 6x29 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | H | 259 | 6x29 | G.H5 | F | 350 | G.H5.26 |
Polar | TM4 | S | 152 | 4x38 | G.HN | K | 20 | G.HN.48 |
Hydrophobic | TM4 | S | 152 | 4x38 | G.HN | K | 20 | G.HN.48 |
Polar | H8 | N | 328 | 8x49 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM3 | I | 143 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM3 | I | 143 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Ionic | TM6 | R | 256 | 6x26 | G.h4s6 | E | 314 | G.h4s6.12 |
Polar | TM6 | R | 256 | 6x26 | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | TM6 | R | 256 | 6x26 | G.h4s6 | E | 314 | G.h4s6.12 |
Van-der-waals | TM6 | R | 256 | 6x26 | G.h4s6 | E | 314 | G.h4s6.12 |
Polar | TM2 | N | 74 | 2x37 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | TM2 | N | 74 | 2x37 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM5 | R | 240 | 5x64 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | C-term | S | 349 | - | G.H3 | R | 253 | G.H3.16 |
Van-der-waals | C-term | S | 349 | - | G.H3 | R | 253 | G.H3.16 |
Polar | C-term | L | 352 | - | G.H3 | H | 252 | G.H3.15 |
Hydrophobic | C-term | L | 352 | - | G.H3 | H | 252 | G.H3.15 |
Van-der-waals | C-term | L | 352 | - | G.H3 | H | 252 | G.H3.15 |
Hydrophobic | TM6 | L | 255 | 6x25 | G.h4s6 | D | 311 | G.h4s6.09 |
Van-der-waals | TM6 | L | 255 | 6x25 | G.h4s6 | D | 311 | G.h4s6.09 |
Hydrophobic | ICL2 | T | 147 | - | G.H5 | F | 332 | G.H5.08 |
Hydrophobic | C-term | L | 366 | - | G.s4h3 | N | 237 | G.s4h3.15 |
Van-der-waals | C-term | L | 366 | - | G.s4h3 | N | 237 | G.s4h3.15 |
Polar | ICL2 | P | 146 | - | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | C-term | L | 354 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Van-der-waals | C-term | L | 354 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Hydrophobic | C-term | L | 366 | - | G.s4h3 | V | 229 | G.s4h3.07 |
Polar | H8 | N | 328 | 8x49 | G.H5 | K | 345 | G.H5.21 |
Van-der-waals | H8 | N | 328 | 8x49 | G.H5 | K | 345 | G.H5.21 |
Polar | TM2 | T | 76 | 2x39 | G.H5 | D | 346 | G.H5.22 |
Polar | H8 | T | 327 | 8x48 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | H8 | T | 327 | 8x48 | G.H5 | G | 348 | G.H5.24 |
Ionic | C-term | H | 358 | - | G.s4h3 | D | 233 | G.s4h3.11 |
Polar | C-term | H | 358 | - | G.s4h3 | D | 233 | G.s4h3.11 |
Hydrophobic | C-term | H | 358 | - | G.s4h3 | D | 233 | G.s4h3.11 |
Van-der-waals | C-term | H | 358 | - | G.s4h3 | D | 233 | G.s4h3.11 |
Polar | TM6 | R | 256 | 6x26 | G.S6 | Y | 316 | G.S6.02 |
Ionic | TM6 | R | 256 | 6x26 | G.H5 | D | 337 | G.H5.13 |
Polar | TM6 | R | 256 | 6x26 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | TM6 | R | 256 | 6x26 | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | TM6 | R | 256 | 6x26 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | C-term | L | 352 | - | G.H3 | N | 251 | G.H3.14 |
Van-der-waals | C-term | L | 352 | - | G.H3 | N | 251 | G.H3.14 |
Hydrophobic | TM5 | F | 248 | 5x72 | G.H5 | D | 333 | G.H5.09 |
Van-der-waals | TM5 | F | 248 | 5x72 | G.H5 | D | 333 | G.H5.09 |
Hydrophobic | ICL2 | P | 146 | - | G.H5 | I | 340 | G.H5.16 |
Van-der-waals | ICL2 | P | 146 | - | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | TM5 | L | 241 | 5x65 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | ICL2 | T | 147 | - | G.H5 | I | 339 | G.H5.15 |
Polar | ICL2 | T | 147 | - | G.s2s3 | K | 188 | G.s2s3.01 |
Hydrophobic | C-term | L | 366 | - | G.s4h3 | V | 236 | G.s4h3.14 |
Hydrophobic | TM5 | L | 241 | 5x65 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | C-term | T | 356 | - | G.H2 | K | 205 | G.H2.05 |
Hydrophobic | ICL2 | P | 146 | - | G.H5 | T | 336 | G.H5.12 |
Polar | TM3 | R | 139 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | R | 139 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | R | 139 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Polar | TM4 | S | 154 | 4x40 | G.HN | K | 20 | G.HN.48 |
Van-der-waals | TM4 | S | 154 | 4x40 | G.HN | K | 20 | G.HN.48 |
Hydrophobic | C-term | L | 354 | - | G.H3 | H | 252 | G.H3.15 |
Polar | C-term | P | 353 | - | G.H3 | S | 248 | G.H3.11 |
Van-der-waals | C-term | P | 353 | - | G.H3 | S | 248 | G.H3.11 |
Polar | C-term | H | 358 | - | G.H2 | R | 201 | G.H2.01 |
Aromatic | C-term | H | 358 | - | G.H2 | R | 201 | G.H2.01 |
Van-der-waals | C-term | H | 358 | - | G.H2 | R | 201 | G.H2.01 |
Polar | ICL3 | Y | 253 | - | G.h4s6 | R | 310 | G.h4s6.08 |
Hydrophobic | ICL3 | Y | 253 | - | G.h4s6 | R | 310 | G.h4s6.08 |
Van-der-waals | ICL3 | Y | 253 | - | G.h4s6 | R | 310 | G.h4s6.08 |
Hydrophobic | TM6 | V | 263 | 6x33 | G.H5 | F | 350 | G.H5.26 |
Polar | C-term | S | 365 | - | G.hgh4 | C | 282 | G.hgh4.01 |
Hydrophobic | TM3 | I | 143 | 3x54 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | TM5 | F | 248 | 5x72 | G.H5 | F | 330 | G.H5.06 |
Polar | ICL2 | K | 150 | - | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | ICL2 | K | 150 | - | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | K | 150 | - | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM6 | M | 260 | 6x30 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | C-term | V | 361 | - | G.H3 | H | 244 | G.H3.07 |
Van-der-waals | TM5 | R | 240 | 5x64 | G.H5 | T | 336 | G.H5.12 |
Polar | C-term | S | 365 | - | G.H3 | H | 240 | G.H3.03 |
Hydrophobic | C-term | S | 365 | - | G.H3 | H | 240 | G.H3.03 |
Van-der-waals | C-term | S | 365 | - | G.H3 | H | 240 | G.H3.03 |
Hydrophobic | TM3 | L | 142 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | L | 142 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM5 | Q | 244 | 5x68 | G.H5 | I | 340 | G.H5.16 |
Van-der-waals | TM5 | Q | 244 | 5x68 | G.H5 | I | 340 | G.H5.16 |