G14 -
PTH2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | T | 347 | 5x68 | G.h4s6 | V | 319 | G.h4s6.20 |
Hydrophobic | TM3 | I | 265 | 3x58 | G.H5 | L | 349 | G.H5.20 |
Aromatic | ICL2 | F | 269 | - | G.H5 | F | 337 | G.H5.08 |
Hydrophobic | ICL2 | F | 269 | - | G.H5 | F | 337 | G.H5.08 |
Van-der-waals | ICL2 | F | 269 | - | G.H5 | F | 337 | G.H5.08 |
Hydrophobic | TM3 | E | 257 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | E | 257 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | I | 265 | 3x58 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM3 | I | 265 | 3x58 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | C-term | I | 490 | - | G.H3 | P | 258 | G.H3.16 |
Polar | C-term | S | 498 | - | G.s4h3 | E | 241 | G.s4h3.14 |
Van-der-waals | C-term | S | 498 | - | G.s4h3 | E | 241 | G.s4h3.14 |
Hydrophobic | C-term | P | 493 | - | G.H3 | I | 254 | G.H3.12 |
Polar | C-term | T | 491 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | C-term | T | 491 | - | G.H3 | Y | 257 | G.H3.15 |
Van-der-waals | C-term | T | 491 | - | G.H3 | Y | 257 | G.H3.15 |
Polar | C-term | S | 500 | - | G.s4h3 | E | 241 | G.s4h3.14 |
Hydrophobic | C-term | S | 500 | - | G.s4h3 | E | 241 | G.s4h3.14 |
Van-der-waals | C-term | S | 500 | - | G.s4h3 | E | 241 | G.s4h3.14 |
Hydrophobic | ICL2 | T | 273 | - | G.HN | K | 30 | G.HN.52 |
Van-der-waals | ICL2 | T | 273 | - | G.HN | K | 30 | G.HN.52 |
Polar | TM3 | L | 264 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | L | 264 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | C-term | V | 496 | - | G.H3 | A | 249 | G.H3.07 |
Van-der-waals | C-term | V | 496 | - | G.H3 | A | 249 | G.H3.07 |
Polar | C-term | L | 492 | - | G.H3 | Y | 257 | G.H3.15 |
Van-der-waals | C-term | L | 492 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | C-term | G | 494 | - | G.H2 | R | 210 | G.H2.05 |
Polar | TM6 | S | 364 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | S | 364 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | S | 364 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM2 | H | 180 | 2x50 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | C-term | S | 498 | - | G.H3 | E | 245 | G.H3.03 |
Polar | C-term | P | 493 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | C-term | P | 493 | - | G.H3 | Y | 257 | G.H3.15 |
Van-der-waals | C-term | P | 493 | - | G.H3 | Y | 257 | G.H3.15 |
Ionic | ICL2 | D | 272 | - | G.hns1 | R | 33 | G.hns1.02 |
Polar | ICL2 | D | 272 | - | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | ICL2 | D | 272 | - | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | ICL2 | D | 272 | - | G.hns1 | R | 33 | G.hns1.02 |
Polar | TM2 | T | 175 | 2x45 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | ICL2 | F | 269 | - | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | C-term | P | 493 | - | G.H3 | L | 250 | G.H3.08 |
Hydrophobic | C-term | P | 493 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | P | 493 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | TM5 | L | 340 | 5x61 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | C-term | S | 498 | - | G.H3 | A | 249 | G.H3.07 |
Hydrophobic | C-term | V | 496 | - | G.H3 | L | 250 | G.H3.08 |
Hydrophobic | TM6 | L | 368 | 6x45 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | L | 368 | 6x45 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | I | 490 | - | G.H3 | Y | 257 | G.H3.15 |
Van-der-waals | C-term | I | 490 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | TM5 | L | 340 | 5x61 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM5 | L | 340 | 5x61 | G.H5 | L | 349 | G.H5.20 |
Polar | TM7 | C | 416 | 7x60 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM7 | C | 416 | 7x60 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM6 | K | 360 | 6x37 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM6 | K | 360 | 6x37 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | C-term | S | 498 | - | G.H3 | E | 246 | G.H3.04 |
Polar | ICL2 | S | 271 | - | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | C-term | L | 492 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | C-term | L | 492 | - | G.H2 | I | 213 | G.H2.08 |
Hydrophobic | C-term | I | 490 | - | G.H3 | W | 259 | G.H3.17 |
Van-der-waals | C-term | I | 490 | - | G.H3 | W | 259 | G.H3.17 |
Polar | C-term | Y | 495 | - | G.H2 | R | 210 | G.H2.05 |
Aromatic | C-term | Y | 495 | - | G.H2 | R | 210 | G.H2.05 |
Hydrophobic | C-term | Y | 495 | - | G.H2 | R | 210 | G.H2.05 |
Hydrophobic | TM7 | Y | 413 | 7x57 | G.H5 | F | 352 | G.H5.23 |
Polar | TM7 | I | 412 | 7x56 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM3 | Y | 260 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | Y | 260 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Ionic | TM2 | R | 176 | 2x46 | G.H5 | E | 351 | G.H5.22 |
Polar | TM2 | R | 176 | 2x46 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | TM2 | R | 176 | 2x46 | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | TM2 | R | 176 | 2x46 | G.H5 | E | 351 | G.H5.22 |
Ionic | ICL1 | R | 170 | 12x48 | G.HN | E | 22 | G.HN.44 |
Polar | ICL1 | R | 170 | 12x48 | G.HN | E | 22 | G.HN.44 |
Hydrophobic | ICL1 | R | 170 | 12x48 | G.HN | E | 22 | G.HN.44 |
Van-der-waals | ICL1 | R | 170 | 12x48 | G.HN | E | 22 | G.HN.44 |
Aromatic | TM2 | R | 176 | 2x46 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM2 | R | 176 | 2x46 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM2 | R | 176 | 2x46 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | C-term | V | 496 | - | G.H3 | T | 253 | G.H3.11 |
Van-der-waals | C-term | V | 496 | - | G.H3 | T | 253 | G.H3.11 |
Ionic | TM5 | K | 343 | 5x64 | G.H5 | D | 342 | G.H5.13 |
Polar | TM5 | K | 343 | 5x64 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | K | 343 | 5x64 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM3 | L | 264 | 3x57 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | L | 264 | 3x57 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM6 | V | 367 | 6x44 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | A | 268 | - | G.H5 | K | 341 | G.H5.12 |
Van-der-waals | ICL2 | A | 268 | - | G.H5 | K | 341 | G.H5.12 |
Hydrophobic | ICL2 | F | 269 | - | G.S3 | F | 197 | G.S3.03 |
Hydrophobic | C-term | C | 504 | - | G.s4h3 | N | 240 | G.s4h3.13 |
Hydrophobic | H8 | N | 417 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | H8 | N | 417 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM3 | L | 261 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | F | 269 | - | G.S3 | I | 195 | G.S3.01 |
Van-der-waals | ICL2 | F | 269 | - | G.S3 | I | 195 | G.S3.01 |
Hydrophobic | ICL2 | F | 269 | - | G.S1 | L | 36 | G.S1.02 |
Van-der-waals | ICL2 | F | 269 | - | G.S1 | L | 36 | G.S1.02 |
Polar | C-term | C | 504 | - | G.s4h3 | C | 238 | G.s4h3.11 |
Hydrophobic | C-term | C | 504 | - | G.s4h3 | C | 238 | G.s4h3.11 |
Van-der-waals | C-term | C | 504 | - | G.s4h3 | C | 238 | G.s4h3.11 |
Hydrophobic | C-term | G | 494 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | G | 494 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | TM3 | L | 261 | 3x54 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM5 | K | 343 | 5x64 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM5 | K | 343 | 5x64 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | C-term | P | 493 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Hydrophobic | C-term | P | 493 | - | G.H2 | W | 212 | G.H2.07 |